Results 21 to 30 of about 25,164 (313)

Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines

Scientific Reports, 2021
Breast cancer is the most prevalent malignancy amongst women worldwide while ovarian cancer represents the leading cause of death among gynecological malignancies. Women suffering from these cancers displayed heightened rates of major depressive disorder,
Britta Stapel, Catharina Melzer, Juliane von der Ohe, Peter Hillemanns, Stefan Bleich, Kai G. Kahl, Ralf Hass   +6 more
doaj   +1 more source

Remote Digital Measurement of Facial and Vocal Markers of Major Depressive Disorder Severity and Treatment Response: A Pilot Study

Frontiers in Digital Health, 2021
Objectives: Multiple machine learning-based visual and auditory digital markers have demonstrated associations between major depressive disorder (MDD) status and severity.
Anzar Abbas, Colin Sauder, Colin Sauder, Vijay Yadav, Vidya Koesmahargyo, Allison Aghjayan, Serena Marecki, Miriam Evans, Isaac R. Galatzer-Levy, Isaac R. Galatzer-Levy   +9 more
doaj   +1 more source

Obsessive Compulsive Disorder, Serotonergic System and Serotonin Reuptake Inhibitors

Psychiatry and Clinical Psychopharmacology, 2021
The observation tht clomipramin, fluvoksamin, and fluoxetine, which are potent blockers of serotonin (5-hydroxytryptamin [5-HT] uptake, are also effective in the treatment of obsessive-compulsive disorder (OCD) has led to the hypothesis that a ...
Alaattin DURAN
doaj  

Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway

Cell Communication and Signaling, 2018
Background Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis.
Suryakant Niture, Maxwell A. Gyamfi, Habib Kedir, Elena Arthur, Habtom Ressom, Gagan Deep, Deepak Kumar   +6 more
doaj   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

EJNMMI Research, 2020
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia.
Thomas Blom, Rutger Meinsma, Marja Rutgers, Corine Buitenhuis, Marieke Dekken-Van den Burg, André B. P. van Kuilenburg, Godelieve A. M. Tytgat   +6 more
doaj   +1 more source

Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells

Reproductive Biology and Endocrinology, 2022
Background Three primary monoamines—serotonin, norepinephrine, and dopamine—play major roles in the placenta-fetal brain axis. Analogously to the brain, the placenta has transport mechanisms that actively take up these monoamines into trophoblast cells ...
Veronika Vachalova, Rona Karahoda, Martina Ottaviani, Kasin Yadunandam Anandam, Cilia Abad, Christiane Albrecht, Frantisek Staud   +6 more
doaj   +1 more source

Comparative Analysis between Controlled Release Paroxetine and Extended-Release Venlafaxine for Treatment of Depression

Journal of Nobel Medical College, 2022
Backgroud: Depression is a common condition seen in Psychiatry outpatient department. The treatment data suggest that the drugs that modulate the serotonergic neurotransmission are effective in the treatment of depression.
Vijay Kaul, Prithi Bahadur Rai
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

RETRACTED: Clinical effectiveness and treatment satisfaction between two triple‐therapy regimens in treating neuropathic pain: A real‐world data

Ibrain, EarlyView., 2023
This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju, Samyuktha Villavan, Saranya Ravi, Roja Murugesan, Panneerselvam Theivendren, Vennila Jaganathan, Redlin Jani Rajan, Krupanidhi Karunanithi   +7 more
wiley   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source