Results 31 to 40 of about 25,164 (313)

A mechanism of uncompetitive inhibition of the serotonin transporter

eLife, 2023
The serotonin transporter (SERT/SLC6A4) is arguably the most extensively studied solute carrier (SLC). During its eponymous action – that is, the retrieval of serotonin from the extracellular space – SERT undergoes a conformational cycle.
Shreyas Bhat, Ali El-Kasaby, Ameya Kasture, Danila Boytsov, Julian B Reichelt, Thomas Hummel, Sonja Sucic, Christian Pifl, Michael Freissmuth, Walter Sandtner   +9 more
doaj   +1 more source

Organic Electrochemical Transistors for Neuromorphic Devices and Applications

Advanced Materials, EarlyView.
Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang, Jiajun Song, Hong Liu, Junxin Chen, Feng Yan   +4 more
wiley   +1 more source

Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport

Scientific Reports, 2018
Citalopram prevents serotonin (5-HT) uptake into platelets by blocking the serotonin reuptake transporter (SERT). Although some clinical data suggest that selective serotonin reuptake inhibitors (SSRIs) may affect haemostasis and thrombosis, these poorly-
Harvey G. Roweth, Ruoling Yan, Nader H. Bedwani, Alisha Chauhan, Nicole Fowler, Alice H. Watson, Jean-Daniel Malcor, Stewart O. Sage, Gavin E. Jarvis   +8 more
doaj   +1 more source

Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells

Frontiers in Pharmacology, 2013
The serotonin (5-HT) uptake system is supposed to play a crucial part in vascular functions by fine-tuning the local concentration of 5-HT in the vicinity of 5-HT2 receptors in vascular smooth muscle cells.
Rachel Wai-sum Li, Cui eYang, Yiu-Wa eKwan, Shun-Wan eChan, Simon Ming-Yuen Lee, George Pak-Heng Leung   +5 more
doaj   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Efficacy of Dapoxetine in the Treatment of Patients With Lifelong Premature Ejaculation as an Alternative to Sertraline Therapy

Sexual Medicine, 2022
: Introduction: Before dapoxetine was approved for the treatment of lifelong premature ejaculation (LPE) in China, daily dosing with off-label sertraline was common. Aim: To investigate the efficacy of dapoxetine in the treatment of patients with LPE as
Guoxiong Liu, MD, Yinghao Yin, MD, Lei Zhang, MD, Dalin He, MD, PhD, Lin Yang, MD, PhD   +4 more
doaj   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Premature ejaculation - current concepts in the management: A narrative review

International Journal of Reproductive BioMedicine, 2021
Premature ejaculation (PE; early ejaculation or rapid ejaculation) is a common sexual problem affecting about 20-30% of men in the sexually active age group. PE can be of four types: Primary, secondary, natural variable, and subjective PE.
Arkiath Veettil Raveendran, Ankur Agarwal   +1 more
doaj   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Management of Premenstrual Disorders

Kerala Journal of Psychiatry, 2017
The impact of premenstrual disorders(PMDs) on women’s lives is largely under-recognized. Inconsistent diagnostic guidelines and poor evidence base for effective treatment strategies lead to inadequate management.
Anisha Nakulan
doaj   +1 more source