Results 81 to 90 of about 134,892 (370)

Detection and serotyping of pneumococci in community acquired pneumonia patients without culture using blood and urine samples

BMC Infectious Diseases, 2015
BackgroundTreatment of community acquired pneumonia (CAP) patients with antibiotics before laboratory-confirmed diagnosis leads to loss of knowledge on the causative bacterial pathogen.
K. Elberse, S. V. van Mens, A. Cremers, S. Meijvis, B. Vlaminckx, M. D. de Jonge, J. Meis, C. Blauwendraat, I. van de Pol, L. Schouls   +9 more
semanticscholar   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

GeoDEN: A Visual Exploration Tool for Analysing the Geographic Spread of Dengue Serotypes [PDF]

Computer Graphics Forum (2025)
Static maps and animations remain popular in spatial epidemiology of dengue, limiting the analytical depth and scope of visualisations. Over half of the global population live in dengue endemic regions. Understanding the spatiotemporal dynamics of the four closely related dengue serotypes, and their immunological interactions, remains a challenge at a ...
arxiv   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Revisitingmolecular serotyping of Streptococcus pneumoniae

BMC Genomics, 2015
BackgroundNinety-two Streptococcus pneumoniae serotypes have been described so far, but the pneumococcal conjugate vaccine introduced in the Brazilian basic vaccination schedule in 2010 covers only the ten most prevalent in the country.
D. R. Camargo, F. Pais, A. Volpini, M. A. Oliveira, R. Coimbra   +4 more
semanticscholar   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

GENETIC SURVEY OF INVASIVE S. PNEUMONIAE SEROTYPES IN BULGARIA FOR A 5-YEAR PERIOD

Problems of Infectious and Parasitic Diseases, 2018
Streptococcus pneumoniae colonises the mucosal lining of the upper respiratory tract and is an important cause of invasive infections affecting young children, adults over 65 years of age, the immunocompromised and individuals with chronic diseases ...
Ivan Simeonovski, Viktoriya Levterova, Mariya Malcheva, Todor Kantardjiev   +3 more
doaj   +1 more source

Rapid prediction of crucial hotspot interactions for icosahedral viral capsid self-assembly by energy landscape atlasing validated by mutagenesis [PDF]

, 2020
Icosahedral viruses have their infectious genome encapsulated by a shell assembled by a multiscale process, starting from an integer multiple of 60 viral capsid or coat protein (VP) monomers. We predict and validate inter-atomic hotspot interactions between VP monomers that are important for the assembly of 3 icosahedral viral capsids: Adeno ...
arxiv   +1 more source

Multilocus Sequence Typing as a Replacement for Serotyping in Salmonella enterica

PLoS Pathogens, 2012
Salmonella enterica subspecies enterica is traditionally subdivided into serovars by serological and nutritional characteristics. We used Multilocus Sequence Typing (MLST) to assign 4,257 isolates from 554 serovars to 1092 sequence types (STs).
M. Achtman, J. Wain, F. Weill, S. Nair, Zhemin Zhou, V. Sangal, M. Krauland, James Hale, H. Harbottle, A. Uesbeck, G. Dougan, L. Harrison, S. Brisse   +12 more
semanticscholar   +1 more source

Serotyping of Acinetobacter calcoaceticus. [PDF]

Journal of Clinical Pathology, 1984
Serotyping of Acinetobacter calcoaceticus by direct immunofluorescence and a capsule swelling reaction is described. One hundred isolates, including 12 from an outbreak in a neonatal department, were studied. Ninety five per cent of the isolates were typable by immunofluorescence and could be divided into 30 separate types, but 42.1% of typable strains,
G Ayliffe, B C Das
openaire   +3 more sources