Results 111 to 120 of about 142,377 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Primary fallopian tube carcinoma presenting with a solitary metastasis in a Spigelian hernia [PDF]

, 2008
Primary fallopian tube carcinoma (PFTC) is a rare gynaecological tumour. Histologically, this type of tumour resembles other tumours of the female reproductive tract, predominantly serous tumours.
Sultana, Angela, Schembri, Mark, Schembri Wismayer, David, Scerri, Albert P.   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Gastric metastasis of ovarian serous cystadenocarcinoma

, 2018
Shiqiang Yang Xintai Hospital Affiliated to Taishan Medical University, Tai’an City, People’s Republic of China Background: Gastric metastasis from ovarian serous cystadenocarcinoma is extremely rare.
Yang S
core  

Serous Neoplasms

, 2015
Serous pancreatic neoplasms are cystic tumors, usually detected as solitary lesions. The most common is the serous cystadenoma (SCA).
D’Onofrio Mirko, Mucelli Roberto Pozzi, De Robertis Riccardo, Capelli Paola, Luchini Claudio, Canestrini Stefano, Gobbo Stefano, Martini Paolo Tinazzi, Morana Giovanni   +8 more
core   +1 more source

Application of the International System for Reporting Serous Fluid Cytopathology in a Tertiary Care Center of North India

Archives of Medicine and Health Sciences
Background and Aim: The International System for Reporting Serous Fluid Cytopathology was designed to standardize the reporting of serous fluid cytology, which we have applied for the reporting of serous fluid cytology in the present study. Materials and
Mohd Rafey, Kafil Akhtar, Fatima Meraj, Murad Ahmed, Mohammad Jaseem Hassan   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Navigated focal laser photocoagulation for central serous chorioretinopathy

, 2014
Jay Chhablani,1 Padmaja Kumari Rani,1 Annie Mathai,1 Subhadra Jalali,1 Igor Kozak2 1Srimati Kanuri Santhamma Vitreo-Retina Service, L V Prasad Eye Institute, Hyderabad, India; 2Division of Vitreoretinal Diseases and Surgery, King Khaled Eye ...
Mathai A, Rani PK, Jalali S, Chhablani J, Kozak I   +4 more
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