Results 141 to 150 of about 43,231 (331)

Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson’s Disease

Journal of Molecular Neuroscience, 2015
Neuroinflammation is thought to contribute to cell death in neurodegenerative disorders, but the factors involved in the inflammatory process are not completely understood.
M. J. Hurley, P. Durrenberger, S. Gentleman, A. Walls, D. Dexter   +4 more
semanticscholar   +1 more source

Ellagic Acid Alleviates Abnormal Fat Reduction by Activating the RXRβ–PPARγ Pathways in a CT26 Tumour‐Induced Cachexia Mouse Model

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cancer cachexia is a syndrome characterized by significant weight loss, particularly of adipose tissue, which negatively impacts patient survival. Pharmacological approaches to prevent this abnormal fat reduction remain poorly defined.
Woo Yong Park, Beomsu Kim, Gahee Song, Sang Hee Kim, Jin‐Hyung Kim, Ja Yeon Park, Se Jin Jung, Wenjun Jiao, Jisoo Han, Taekyoung Kong, Kwang Seok Ahn, Hyun Jeong Kwak, Jae‐Young Um   +12 more
wiley   +1 more source

Role of Lys335 in the metastability and function of inhibitory serpins [PDF]

, 2000
Hana Im, Myeong‐Hee Yu
openalex   +1 more source

Therapeutic Effects of Noninvasive Electrical Stimulation in Combination Transplantation of Human Adipose‐Derived Stem Cells‐Derived Dopaminergic Neuron on the Monkey Model of Parkinson's Disease

MedComm, Volume 7, Issue 2, February 2026.
Our results showed that noninvasive electrical stimulation (NES) alone or in combination with human adipose‐derived stem cells (hADSCs)‐induced dopaminergic neuron (NES‐DN) improved the behavioral deficits and pathological features of the MPTP‐induced PD monkey model.
Chunhui Huang, Shane Gao, Xiao Zheng, Xichen Song, Jiaxi Wu, Kai Liao, Jiawei Li, Yingqi Lin, Caijuan Li, Yaqun Lu, Jiahao Feng, Huiyi Wei, Lu Wang, Hao Xu, Wei Wang, Yizhi Chen, Jianhao Wu, Jiale Gao, Junzhu Song, Chunxiang Shi, Jun Zhang, Sen Yan   +21 more
wiley   +1 more source

The Role of PEDF in the Eye, Bone, and Nervous and Immune Systems

Pharmaceutics
This review highlights recent findings on the versatile inactive serpin protein, pigment epithelium-derived factor (PEDF) in the eye, bone, and nervous and immune systems. PEDF is highly conserved and found at the 17p13.3 locus in humans.
Krittikan Chanpaisaeng, Crispin R. Dass
doaj   +1 more source

Differential gene expression for suicide-substrate serine proteinase inhibitors (serpins) in vegetative and grain tissues of barley [PDF]

, 2003
Thomas H. Roberts
openalex   +1 more source

Integrative Single‐Cell Analysis Reveals Targetable Vacuole Membrane Protein 1‐Mediated Mechanism of Tumor Angiogenesis in Glioblastoma

MedComm, Volume 7, Issue 2, February 2026.
VMP1 promotes angiogenesis in glioblastoma (GBM) through VEGFA‐VEGFR2 signaling and activation of endothelial cells. The FDA‐approved anti‐VEGFA antibody, bevacizumab (BEV), can counteract VMP1's tumor‐promoting effect in GBM. Targeting VMP1 or its associated pathways could be a new therapeutic strategy, either alone or in combination with BEV.
Lei Jin, Bo Chen, Junbo Liao, Wenlong Guo, Zhiyuan Zhu, Salida Ali, Gilberto Ka‐Kit Leung, Peng Wang, Karrie M. Kiang   +8 more
wiley   +1 more source

Human Skin-Derived Mast Cells Spontaneously Secrete Several Angiogenesis-Related Factors

Frontiers in Immunology, 2019
Mast cells are classically recognized as cells that cause IgE-mediated allergic reactions. However, their ability to store and secrete vascular endothelial growth factor (VEGF) suggests a role in vascular development and tumorigenesis.
Cody McHale, Zahraa Mohammed, Gregorio Gomez   +2 more
doaj   +1 more source

Immunological Detection of Conformational Neoepitopes Associated with the Serpin Activity of Plasminogen Activator Inhibitor Type-2 [PDF]

, 1998
Darren N. Saunders, Kathy Buttigieg, Alison R. Gould, Virginia McPhun, Mark S. Baker   +4 more
openalex   +1 more source

Remote Pancreatic Response to Severe Polytrauma Correlates With Clinical Outcome

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Acute pancreatic injury can result from blunt or sharp force trauma, often leading to serious complications. While direct pancreatic trauma is associated with high rates of infection, organ failure, and mortality, little is known about the pancreas as a potential secondary target and remote trauma organ and thereby as a booster of ...
Rebecca Halbgebauer, Lisa Wohlgemuth, Jonas Wrba, Sonja Braumüller, Enes Kumral, Ludmila Lupu, Clara Morgenstern, Lucas Bettac, Sebastian Wiese, Benjamin Mayer, Paolo Cinelli, Daniel Rittirsch, Hans‐Christoph Pape, Francesco Roselli, Thomas Seufferlein, Alexander Kleger, Markus Breunig, Markus Huber‐Lang   +17 more
wiley   +1 more source