Results 121 to 130 of about 23,239 (235)

Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses

Genetics and Molecular Biology, 2011
The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through ...
Aline Correa da Silva, Karin Erica Brass, Elgion da Silva Loreto, Myriam Elizabeth Vinocur, Ricardo Pozzobon, Marcos da Silva Azevedo   +5 more
doaj  

Systematic Analysis of Plasma‐Derived Extracellular Vesicle‐Enriched Samples in Age‐Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Vision impairment caused by age‐related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by ageing and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progression, and a source of biomarkers to support ...
Marzena Kurzawa‐Akanbi, Jennifer Haggarty, Carina Hansohn, Mohamed T. Patel, Angela J. Cree, Peisi Teo, Milly Armstrong, Nathan Coles, Mark Platt, Helen Griffiths, Heather J. Cordell, Ahmad Khundakar, Pola Goldberg Oppenheimer, Phillip Whitfield, Andrew Lotery, Henning Urlaub, Sina Mozaffari‐Jovin, Majlinda Lako   +17 more
wiley   +1 more source

Development, characterization, and optimization of nanobody for targeting Serpin B3

embargoed_20270916Serpin B3 (SCCA1) è una proteina umana appartenente alla famiglia degli inibitori delle serin proteasi (SERPINs), coinvolta in vari processi patologici, inclusi la proliferazione cellulare, l'invasione dei tessuti e la resistenza ai ...
BURGIO, MICHELE
core  

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Immature Neutrophil Phenotype and Enhanced Myeloperoxidase in Male Patients With Chronic Kidney Disease and Cardiovascular Comorbidity

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim Patients with chronic kidney disease (CKD) have an increased cardiovascular risk. Since neutrophils and neutrophil‐borne proteins contribute to cardiovascular disease, we analyzed the neutrophil phenotype in patients with CKD who presented with a spectrum of cardiovascular comorbidities.
Sonja Vondenhoff, Alessandra Antwerpen, Carolina Victoria Cruz Junho, Philipp Martin, Sina Hourtz, Jinmi Zou, Berkan Kurt, Carolin Haas, Susanne Fleig, Corinna Schulte, Jane Lauxen, Martina Wessiepe, Ulrike Späte‐Schulze, Rafael Kramann, Jürgen Floege, Oliver Soehnlein, Joachim Jankowski, Claudia Goettsch, Yvonne Döring, Florian Kahles, Nikolaus Marx, Constance C. F. M. J. Baaten, Heidi Noels   +22 more
wiley   +1 more source

Engineering serpin stability and function

, 2019
Protein engineering was performed to create an a1-antitrypsin-like serpin that is thermostable while remaining functional. The base molecule for this engineering is a consensus-designed serpin, conserpin, which exhibits extreme thermostability while also
EMILIA MARIA MARIJANOVIC (6317213)
core   +1 more source

Genetic Alterations in the SERPIN Gene Family as Predictors of Immune Checkpoint Therapy Efficacy in Melanoma and Non‐Small Cell Lung Cancer

Medicine Advances
Background Identifying reliable biomarkers for immune checkpoint therapy response remains a critical challenge in immuno‐oncology. While tumor mutation burden (TMB) effectively predicts treatment outcomes, its clinical implementation is hindered by cost ...
Jieqiong Li, Di Wang, Yuxin Wang, Lixia Wang, Jinmei Luo, Yi Xiao   +5 more
doaj   +1 more source

Meet the serpins [PDF]

The FEBS Journal, 2005
openaire   +2 more sources

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Murine serpin 2A is a redox-sensitive intracellular protein

, 2003
Murine serpin 2A is expressed at high levels in haemopoietic progenitors and down-regulated on differentiation. When it is constitutively expressed in the multipotent haemopoietic cell line, FDCP-Mix, it causes a delay in differentiation and increased ...
Carrell, Robin W., Forsyth, SL, Hampson, Ian N., Coughlin, Paul B., Timothy R. DAFFORN, Horvath, AJ, Anita J. HORVATH, Hamson, IN, Dafforn, Timothy R., Morris, EC, Morris, Emma C., Sharon L. FORSYTH, Missen, Melinda A., Emma C. MORRIS, Lynne HAMPSON, Melinda A. MISSEN, Forsyth, Sharon L., Ian N. HAMPSON, Missen, MA, Hampson, Lynne, Graeme CURRIE, Dafforn, Timothy, Paul B. COUGHLIN, Robin W. CARRELL, Currie, Graeme, Hampson, L, Horvath, Anita J.   +26 more
core   +1 more source