Results 111 to 120 of about 23,239 (235)

A curated structural dataset of peptide–protein complexes reveals biases in existing datasets and principles of peptide binding

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Peptide–protein interactions are fundamental to many biological processes, and peptide design is gaining interest due to its therapeutic potential. This has led to the emergence of various structural databases, such as PepBDB and Peptipedia, that classify peptides as polypeptides with fewer than 50 amino acids. These databases provide valuable
Rahma Hamdani, Javier Delgado, Luis Serrano   +2 more
wiley   +1 more source

The Role of PEDF in the Eye, Bone, and Nervous and Immune Systems

Pharmaceutics
This review highlights recent findings on the versatile inactive serpin protein, pigment epithelium-derived factor (PEDF) in the eye, bone, and nervous and immune systems. PEDF is highly conserved and found at the 17p13.3 locus in humans.
Krittikan Chanpaisaeng, Crispin R. Dass
doaj   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, Volume 41, Issue 10, Page 1105-1118, October 2026.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, Volume 35, Issue 5, Page 556-575, October 2026.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Spatial Regulation of Developmental Signaling by a Serpin [PDF]

, 2003
An extracellular serine protease cascade generates the ligand that activates the Toll signaling pathway to establish dorsoventral polarity in the Drosophila embryo.
Kim, Dong Ryoung, Weiss, Linnea A, Morisato, Donald, Hashimoto, Carl, Miller, Jingjing W   +4 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, Volume 36, Issue 71, 3 September 2026.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Loss of Neutrophils and SLPI Reshapes Early Mucosal Inflammatory Responses During Intranasal Vaccination

European Journal of Immunology, Volume 56, Issue 9, September 2026.
Intranasal vaccination induces pulmonary neutrophil accumulation and SLPI release, accompanied by changes in soluble mediators associated with tissue remodelling, coagulation, and total IgA. ABSTRACT Vaccines delivered via the nasal route have attracted increasing attention for their capacity to engage the mucosal immune system at the primary site of ...
Oktawia Osiecka, Mariia Tyshchenko, Ivan Sinkevich, Natalia Pocałuń, Joanna Cichy, Jakub M. Kwiecinski, Ewa Oleszycka, Mieszko M. Wilk   +7 more
wiley   +1 more source

Cardiovascular disease incidence and cancer risk in two large European prospective cohorts

International Journal of Cancer, Volume 159, Issue 5, Page 1139-1152, 1 September 2026.
What's new? Cardiovascular disease (CVD) and cancer share risk factors and biological mechanisms, raising questions about potential associations between the two, particularly regarding CVD duration and cancer onset. Whether CVD influences subsequent cancer risk, however, remains inconclusive.
Emma Fontvieille, Vivian Viallon, Laia Peruchet‐Noray, Quan Gan, N. Charlotte Onland‐Moret, Yvonne Koop, Anne Tjønneland, Nicola Patricia Bondonno, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Catarina Schiborn, Calogero Saieva, Vittorio Simeon, Claudia Agnoli, Rosario Tumino, Fulvio Ricceri, Leila Luján‐Barroso, Maria‐José Sánchez, Conchi Moreno‐Iribas, Konstantinos K. Tsilidis, Marc J. Gunter, Adam Butterworth, Elio Riboli, Heinz Freisling, Pietro Ferrari   +25 more
wiley   +1 more source

Metalorganic Titanium Treatment to Change Enamel Optical Properties

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 9, September 2026.
ABSTRACT Observational studies have shown that human teeth with higher concentrations of titanium traces have better optical properties. The aim of this study was to investigate how titanium ion infiltration into tooth enamel affects its optical properties by studying the diffusion and reactivity of titanium compounds in tooth enamel and how this ...
Yara Oweis, Amir Elhadad, Sophia Smith, Qiman Gao, Emily Buck, Mohamed‐Amine Mezour, Wenge Jiang, Javier Vargas Balbuena, Sailer S. Dos Santos, Marta Cerruti, Faleh Tamimi   +10 more
wiley   +1 more source