Results 101 to 110 of about 23,239 (235)

Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial community composition and host proteome. Materials and Methods Samples were
Miguel Carda‐Diéguez, Stefan Rüdiger, Gunnel Svensäter, Henrik Jansson, Tirthankar Mohanty, Yashuan Chao, Christofer Karlsson, Johan Malmström, Oonagh Shannon, Álex Mira, Julia R. Davies   +10 more
wiley   +1 more source

1D- and 2D-immunoblots of Serpin A1.

, 2012
3A shows 1D-immunoblot band volumes (adjusted for membrane background) of Serpin A1. 3B shows the statistical analysis for the 1D-immunoblot validation of all proteins found to be regulated in the 2D DIGE experiment.
Olaf Jahn (120801), Hans A. Kretzschmar (46374), Martin Lenter (120825), Hayrettin Tumani (120815), Markus Otto (120832), Christine A. F. von Arnim (120817), Lucilla Parnetti (120805), Stefan Lehnert (120797), Sarah Jesse (120792), Jens Wiltfang (44073), Sanna-Kaisa Herukka (120810), Saskia Tawfik (120814), Manuela Neumann (120819), Hasan Kulaksiz (120823), Boris Ferger (120827), Hilkka Soininen (120808), Bastian Hengerer (120831), Petra Steinacker (120812)   +17 more
core   +1 more source

Structural aspects of serpin inhibition [PDF]

, 1994
The essential roles of proteins of the serpin family in many physiological processes, along with new discoveries of their unique folding properties, have attracted intense interest in recent years.
Schulze, Andreas J., Andreas J. Schulze, Huber, Robert, Engh, Richard A., Bode, Wolfram, Robert Huber, Wolfram Bode, Richard A. Engh   +7 more
core   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

The role of SERPIN citrullination in thrombosis

, 2022
Aberrant protein citrullination is associated with many pathologies; however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in rheumatoid ...
Wagner, Denisa, Gutch, Sarah, Sorvillo, Nicoletta, Salinger, Ari J., Cherpokova, Deya, Reyes, Archie C., Thompson, Paul R, Fukui, Saeko, Tilvawala, Ronak, Nemmara, Venkatesh V.   +9 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Expression of maspin in benign and malignant salivary gland tumors: An immunohistochemical study

Indian Journal of Dental Research, 2014
Context: Maspin is a novel serine protease inhibitor (serpin) with multifaceted tumor-suppressive activities. It was originally identified in normal human breast myoepithelial cells and shows variable expression in different types of cancer cells. Maspin
V Reshma, Kavita Rao, N S Priya, H S Umadevi, T Smitha, H S Sheethal   +5 more
doaj   +1 more source

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source