Results 81 to 90 of about 23,239 (235)
KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley +1 more source
, 2014 The canonical serpin fold comprises three β-sheets (yellow), eight to nine α-helices (red) and the reactive centre loop (blue). The proposed sites of the new ligand binding pocket are highlighted in blue (bounded by β-sheet A and helix D) and magenta ...
Randy J. Read (666315) +2 more
core +1 more source
Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2
Phytotherapy Research, EarlyView.ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu +6 more
wiley +1 more source
Schistosome serine protease inhibitors: parasite defense or homeostasis?
Anais da Academia Brasileira de Ciências, 2011 Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic ...
Landys A. Lopez Quezada +1 more
doaj +1 more source
Role of defensins in immunothrombosis
Rheumatology &Autoimmunity, EarlyView.Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang +7 more
wiley +1 more source
Natural antibacterial silk produced by feeding silkworms with human hair derived carbon dots
Responsive Materials, EarlyView.Blue‐fluorescent and antibacterial carbon dots, prepared from Crinis Carbonisatus (a traditional Chinese medicine made by calcinating human hair), are fed to silkworms to produce multifunctional silk, which retains its inherent mechanical properties, exhibits blue fluorescence, possesses antibacterial activity, and promotes the wound healing of rats as
Zhao‐Fan Wu +5 more
wiley +1 more source
Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus [PDF]
, 1998 Recently, myxoma virus was shown to encode an additional member of the serpin superfamily. The viral gene, called serp2, was cloned, and the Serp2 protein was shown to specifically bind to interleukin-1beta (IL-1beta)-converting enzyme (ICE), thus ...
Messud-Petit, Frédérique +6 more
core
OncoImmunology, 2018 Pediatric medulloblastomas are the most frequently diagnosed embryonal tumors of the central nervous system. Current therapies cause severe neurological and cognitive side effects including secondary malignancies.
Jeroen F. Vermeulen +10 more
doaj +1 more source
Biomarkers to predict outcomes in diabetic foot ulcers
VIEW, EarlyView.Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro +6 more
wiley +1 more source
Russian wheat aphid: a model for genomic plasticity and a challenge to breeders
Insect Science, EarlyView.Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn +8 more
wiley +1 more source