Results 71 to 80 of about 23,239 (235)
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Multiple alignment of serpin-4 and serpin-5 with other known serpins.
, 2014 Here serpin-2 (P. xylostella, BAF36820), serpin-4 (Bombyx mori, ACZ81437), serpin-4B (Manduca sexta, AAS68504), serpin-4A (Manduca sexta, AAS68503), serpin-4 (Danaus plexippus, EHJ70588), serpin-5A (Manduca sexta, AAS68507), serpin-4 (Glossina morsitans,
Shunxiang Ren (383521) +6 more
core +1 more source
Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study
Biomedicines, 2023 Approximately 50% of all global blindness is caused by cataract in adults aged ≥50 years. The mechanisms of the disease are most arguably related to a redox imbalance and inflammation; therefore, the aim of the study was to evaluate the processes ...
Paweł Sutkowy +3 more
doaj +1 more source
An overview of the serpin superfamily.
Genome biology, 2006 Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in ...
Law, Ruby HP +10 more
openaire +2 more sources
Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis
Interdisciplinary Medicine, EarlyView.Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar +18 more
wiley +1 more source
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]
, 2015 A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV +7 more
core
Cell & BioscienceBackground Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors secreted by Trichinella spiralis play
Ruixue Li, Bing Zhang, Chen Chen
doaj +1 more source
Binding and sequestration of poison frog alkaloids by a plasma globulin
eLife, 2023 Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation.
Aurora Alvarez-Buylla +9 more
doaj +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Alphitobius diaperinus, the lesser mealworm, is an edible insect considered safe for human consumption; however, its proteins show documented cross‐reactivity with crustacean and house dust mite (HDM) allergens, raising potential concerns for allergic populations.
Michelle M Epstein +8 more
wiley +1 more source
Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins
Biomolecules, 2023 Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood.
Kyle Varkoly +5 more
doaj +1 more source