Results 71 to 80 of about 34,502 (251)
Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study
Biomedicines, 2023 Approximately 50% of all global blindness is caused by cataract in adults aged ≥50 years. The mechanisms of the disease are most arguably related to a redox imbalance and inflammation; therefore, the aim of the study was to evaluate the processes ...
Paweł Sutkowy +3 more
doaj +1 more source
Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]
, 2009 Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
Maizels, R M
core +1 more source
Animal Models and Experimental Medicine, EarlyView.This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin +2 more
wiley +1 more source
Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements
Frontiers in Molecular BiosciencesSerine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes.
Shutong Wu +7 more
doaj +1 more source
Binding and sequestration of poison frog alkaloids by a plasma globulin
eLife, 2023 Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation.
Aurora Alvarez-Buylla +9 more
doaj +1 more source
Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus [PDF]
, 1998 Recently, myxoma virus was shown to encode an additional member of the serpin superfamily. The viral gene, called serp2, was cloned, and the Serp2 protein was shown to specifically bind to interleukin-1beta (IL-1beta)-converting enzyme (ICE), thus ...
Messud-Petit, Frédérique +6 more
core
Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB [PDF]
, 2017 The serpinopathies are human pathologies caused by mutations that promote polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a poorly understood cell toxicity.
Cacci, Emanuele +10 more
core +1 more source
An overview of the serpin superfamily.
Genome biology, 2006 Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in ...
Law, Ruby HP +10 more
openaire +2 more sources
Advanced NanoBiomed Research, EarlyView.Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia +5 more
wiley +1 more source
Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins
Biomolecules, 2023 Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood.
Kyle Varkoly +5 more
doaj +1 more source