Results 91 to 100 of about 23,239 (235)

Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin

, 2009
Delineating the phylogenetic relationships among members of a protein family can provide a high degree of insight into the evolution of domain structure and function relationships.
Luke, Cliff J., Cole, Elisabeth B., Silverman, Gary A., Miller, David M., Bromme, Dieter, Mills, David R., Rometo, David, Greenberg, Robert M., Cataltepe, Sule, Pak, Stephen C.   +9 more
core   +1 more source

LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis

Cancer Science, EarlyView.
This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen, Yunzhong Jiang, Zezhong Yang, Minxuan Jing, Wentai Wu, Jiale He, Lu Wang, Minghai Ma, Yaodong Zhang, Min Wang, Jianpeng Li, Yuanchun Pu, Bingliang He, Yanjia Liu, Kaibo Mi, Hang Liu, Mengzhao Zhang, Jinhai Fan   +17 more
wiley   +1 more source

Characterization of Serpin Family Genes in Three Rice Planthopper Species and Their Expression Profiles in Response to Metarhizium Infection

Agronomy
Rice planthoppers, including Nilaparvata lugens, Sogatella furcifera, and Laodelphax striatellus, are major agricultural pests. Serpins, which function as serine protease inhibitors, play a pivotal role in the immune systems of these insects, especially ...
Ruonan Zhang, Zichun Zhong, Liyan He, Hongxin Wu, Liuyan He, Yujing Guo, Haoming Wu, Xiaoxia Xu, Fengliang Jin, Rui Pang   +9 more
doaj   +1 more source

Protease: Serpin complexes to assess contact system and intrinsic pathway activation

Research and Practice in Thrombosis and Haemostasis, 2020
Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation of factor XII,
Michael W. Henderson, Denis F. Noubouossie, Anton Ilich, Kathy J. Wilson, Rafal Pawlinski, Dougald M. Monroe, Nigel S. Key   +6 more
doaj   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

High Specificity of sIgE to α−/β‐Gliadin and Limited Reactivity to Non‐Gluten Proteins in Wheat Allergy Dependent on Augmentation Factors (WALDA)

Clinical &Experimental Allergy, EarlyView.
This study suggest that WALDA is characterized by highly specific reactivity to gliadin proteins, with limited sensitization to non‐gluten wheat components. sIgE to α‐/β‐gliadin represents a promising diagnostic biomarker with superior specificity compared to ω5‐gliadin alone.
Valentina Faihs, Florian Schusta, Claudia Kugler, Tilo Biedermann, Monika Raulf, Margitta Worm, Knut Brockow, Ingrid Sander   +7 more
wiley   +1 more source

Identification of novel serpin isoforms and serpin polymorphisms among Australian wheat cultivars

, 2012
Serpins constitute a large family of related proteins, the majority of which are serine protease inhibitors (from which their name is derived). They are known to be abundantly and polymorphically expressed in individual wheat cultivars.
Howes, Neil, Chin, James, McKay, Stephen, Hegedus, Elizabeth, Wu, Ming J. (R14880)   +4 more
core   +1 more source

The role of SERPIN citrullination in thrombosis

, 2021
Aberrant protein citrullination is associated with many pathologies, however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in Rheumatoid ...
Thompson, Paul R., Wagner, Denisa, Gutch, Sarah, Sorvillo, Nicoletta, Reyes, Archie C., Denisa Wagner, Ari J. Salinger, Archie C. Reyes, Fukui, Saeko, Nemmara, Venkatesh V., Sarah Gutch, Ronak Tilvawala, Venkatesh V. Nemmara, Salinger, Ari J., Cherpokova, Deya, Nicoletta Sorvillo, Deya Cherpokova, Paul R. Thompson, Saeko Fukui, Tilvawala, Ronak   +19 more
core   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Integrative transcriptomic and machine learning approaches reveal candidate genes for silk and venom production in Bibionomorpha (Diptera)

Insect Molecular Biology, EarlyView.
Multi‐species transcriptomics and deep learning identified candidate genes associated with silk and venom production in Bibionomorpha. Venom‐associated genes were enriched in proteases, inhibitors and pore‐forming proteins, whereas silk‐related genes showed chitin‐binding and peritrophin domains. Integrating co‐expression networks, machine learning and
Daniel Kenji Matuo, João Alfredo Teodoro, Danilo T. Amaral   +2 more
wiley   +1 more source