Results 91 to 100 of about 34,502 (251)

Schistosome serine protease inhibitors: parasite defense or homeostasis?

Anais da Academia Brasileira de Ciências, 2011
Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic ...
Landys A. Lopez Quezada, James H McKerrow   +1 more
doaj   +1 more source

Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. [PDF]

, 2018
Yes-associated protein (YAP) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine ...
Chan, Geraldine, Dai, Yuyuan, Hsu, Ping-Chih, Huang, Zhen, Jablons, David M, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Xu, Zhidong, Yang, Cheng-Ta, Yang, Yi-Lin, Yeh, Che-Chung, You, Joanna, You, Liang   +13 more
core   +1 more source

Serpins in theCaenorhabditis elegans genome [PDF]

Proteins: Structure, Function, and Genetics, 1999
Data mining in genome sequences can identify distant homologues of known protein families, and is most powerful if solved structures are available to reveal the three-dimensional implications of very dissimilar sequences. Here we describe putative serpin sequences identified with very high statistical significance in the Caenorhabditis elegans genome ...
J C, Whisstock, J A, Irving, S P, Bottomley, R N, Pike, A M, Lesk   +4 more
openaire   +2 more sources

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

OncoImmunology, 2018
Pediatric medulloblastomas are the most frequently diagnosed embryonal tumors of the central nervous system. Current therapies cause severe neurological and cognitive side effects including secondary malignancies.
Jeroen F. Vermeulen, Wim Van Hecke, Elisabeth J. M. Adriaansen, Mieke K. Jansen, Rianne G. Bouma, José Villacorta Hidalgo, Paul Fisch, Roel Broekhuizen, Wim G. M. Spliet, Marcel Kool, Niels Bovenschen   +10 more
doaj   +1 more source

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. [PDF]

, 2016
The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a
Cieplak, Piotr, Ge, Xin, Nam, Dong Hyun, Remacle, Albert G, Shiryaev, Sergey A, Strongin, Alex Y   +5 more
core   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Protease: Serpin complexes to assess contact system and intrinsic pathway activation

Research and Practice in Thrombosis and Haemostasis, 2020
Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation of factor XII,
Michael W. Henderson, Denis F. Noubouossie, Anton Ilich, Kathy J. Wilson, Rafal Pawlinski, Dougald M. Monroe, Nigel S. Key   +6 more
doaj   +1 more source

Mechanistic behaviour and molecular interactions of heat shock protein 47 (HSP47) [PDF]

, 2012
This project involves the study of heat shock protein 47 (HSP47), which is a molecular chaperone crucial for collagen biosynthesis. It exhibits a high degree of sequence homology with members of the serine protease inhibitor (serpin) superfamily, though ...
Abdul Wahab, Mohd Firdaus, Abdul Wahab, Mohd Firdaus   +1 more
core   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source