Results 161 to 170 of about 24,818 (268)

GEO combined with quantitative protein trait loci identify causative proteins in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 4, Page 2827-2833, August 2025.
Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley   +1 more source

Late‐Stage Skeletal Muscle Transcriptome in Duchenne Muscular Dystrophy Shows a BMP4‐Induced Molecular Signature

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is a fatal X‐linked recessive disease due to loss‐of‐function variants in the DYSTROPHIN gene. DMD‐related skeletal muscle wasting is typified by an aberrant immune response involving upregulation of the TGFβ family of cytokines, like TGFβ1 and BMP4.
Hanna Sothers, Xianzhen Hu, David K. Crossman, Ying Si, Matthew S. Alexander, Merry‐Lynn N. McDonald, Peter H. King, Michael A. Lopez   +7 more
wiley   +1 more source

Molecular cloning and expression of an intracellular serpin: an elastase inhibitor from horse leucocytes [PDF]

, 1993
Tomasz Kordula, Adam Dubin, Heidi Schooltink, Aleksander Koj, Peter C. Heinrich, Stefan Rose‐John   +5 more
openalex   +1 more source

Functional, pathogenic, and pharmacological roles of protein folding intermediates

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1299-1307, August 2025.
Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
wiley   +1 more source

Evaluation of Neutrophil Activity Before and After Granulocyte and Monocyte Adsorptive Apheresis in Patients With Pustular Psoriasis

Therapeutic Apheresis and Dialysis, Volume 29, Issue 4, Page 702-706, August 2025.
ABSTRACT Introduction Activated neutrophils play a crucial role in the development of neutrophilic dermatoses, including pustular psoriasis. Adsorptive granulocyte and monocyte apheresis (GMA) is an effective treatment for skin disorders. Although previous basic research has demonstrated neutrophil activation, no efficient method exists to assess it in
Yuko Higashi, Atsuko Ibusuki, Tomoko Fukushige, Ryoko Sagara, Risako Yonezawa, Natsumi Terada, Hisao Kawahira, Kimiko Kazumura, Takuro Kanekura   +8 more
wiley   +1 more source

The plasmin-antiplasmin system: structural and functional aspects [PDF]

, 2018
The plasmin-antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and α2-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments. However, besides plasmin(
Gerber, Simon, Schaller, Johann
core  

Serpin B9 is Highly Expressed in Lung Adenocarcinoma and is Associated with Progression-Free Survival

Journal of Inflammation Research
Yue Fang,1,2,* Yi Yue,3,* Sensen Hao,1 Ying Zhang,4 Nan Liu,1 Shengling Wang,1 Yan Li,1 Hongzhi Wang1 1Galactophore Oncology Center, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei City, Anhui Province, People’s Republic of China ...
Fang Y, Yue Y, Hao S, Zhang Y, Liu N, Wang S, Li Y, Wang H   +7 more
doaj  

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Aging Cell, Volume 24, Issue 8, August 2025.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu, Joanna Bons, Hannah Anvari, Tomiris Atazhanova, Nicolas Martin, Tommy Tran, Kevin Schneider, Jacob P. Rose, Daniel Winer, Elisheva Shanes, Mary Ellen G. Pavone, Judith Campisi, David Furman, Simon Melov, Birgit Schilling, Francesca E. Duncan   +18 more
wiley   +1 more source

Redefining the Immunobiology of Organ Transplantation for New Clinical Horizons

Scandinavian Journal of Immunology, Volume 102, Issue 2, August 2025.
ABSTRACT Traditional organ transplantation relies on the Self–Non‐self (SNS) model of immunity, focusing on donor–recipient compatibility and aggressive immunosuppression to prevent acute rejection. Although effective early, this strategy does not prevent chronic rejection and cannot account for operational tolerance, failure of perfectly HLA‐matched ...
Masoud H. Manjili
wiley   +1 more source

The transcriptional regulation of maspin : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2004
Maspin (mammary serine protease inhibitor) is a tumour suppressing member of the serpin superfamily. Maspin is expressed in normal breast and prostate cells, but reportedly down regulated during progression of cancer in these tissues.
Hollings, Andrew
core