Results 41 to 50 of about 35,556 (271)

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

Frontiers in Cardiovascular Medicine, 2021
Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential
Elsa P. Bianchini, Claire Auditeau, Mahita Razanakolona, Marc Vasse, Marc Vasse, Delphine Borgel, Delphine Borgel   +6 more
doaj   +1 more source

Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]

, 2013
Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter, Dhaenens, Maarten, Gasser, Robin B, Geldhof, Peter, Jex, Aaron R, Van Steendam, Katleen, Vlaminck, Johnny, Wang, Tao   +7 more
core   +5 more sources

Serpins in thrombosis, hemostasis and fibrinolysis [PDF]

Journal of Thrombosis and Haemostasis, 2007
Hemostasis and fibrinolysis, the biological processes that maintain proper blood flow, are the consequence of a complex series of cascading enzymatic reactions. Serine proteases involved in these processes are regulated by feedback loops, local cofactor molecules, and serine protease inhibitors (serpins).
Frank C. Church, Jill C. Rau, Lea M. Beaulieu, James A. Huntington   +3 more
openaire   +3 more sources

Species-Specific Serological Detection for Schistosomiasis by Serine Protease Inhibitor (SERPIN) in Multiplex Assay. [PDF]

PLoS Neglected Tropical Diseases, 2015
Both Schistosoma mansoni and Schistosoma haematobium cause schistosomiasis in sub-Saharan Africa. We assessed the diagnostic value of selected Schistosoma antigens for the development of a multiplex serological immunoassay for sero-epidemiological ...
Chihiro Tanigawa, Yoshito Fujii, Masashi Miura, Samson Muuo Nzou, Anne Wanjiru Mwangi, Sachiyo Nagi, Shinjiro Hamano, Sammy M Njenga, Evaristus Chibunna Mbanefo, Kenji Hirayama, Matilu Mwau, Satoshi Kaneko   +11 more
doaj   +1 more source

Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

mBio, 2021
Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of all the ...
Arun Dhillon, Justin C. Deme, Emily Furlong, Dorina Roem, Ilse Jongerius, Steven Johnson, Susan M. Lea   +6 more
doaj   +1 more source

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity [PDF]

, 2015
SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood.
Biasiolo, Alessandra, Cannito, Stefania, Cillo, Umberto, Fasolato, Silvano, Gatta, Angelo, Martini, Andrea, Martini, Andrea, Morello, Elisabetta, Parola, Maurizio, Pontisso, Patrizia, Quarta, SANTINA MARIA, Ruvoletto, Mariagrazia, Simonato, Davide, Terrin, Liliana, Turato, Cristian, Villano, Gianmarco, Zanus, Giacomo   +16 more
core   +2 more sources

RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression

Cell Death and Disease, 2022
RNA binding protein HuD plays essential roles in gene expression by regulating RNA metabolism, and its dysregulation is involved in the pathogenesis of several diseases, including tumors, neurodegenerative diseases, and diabetes.
Myeongwoo Jung, Seungyeon Ryu, Chongtae Kim, Seongho Cha, Hoin Kang, Eunbyul Ji, Youlim Hong, Youngjoon Lee, Sukyoung Han, Seung Min Jeong, Wook Kim, Eun Kyung Lee   +11 more
doaj   +1 more source

Angiotensinogen and the Modulation of Blood Pressure

Frontiers in Cardiovascular Medicine, 2021
The angiotensin peptides that control blood pressure are released from the non-inhibitory plasma serpin, angiotensinogen, on cleavage of its extended N-terminal tail by the specific aspartyl-protease, renin. Angiotensinogen had previously been assumed to
Zimei Shu, Jiahui Wan, Randy J. Read, Robin W. Carrell, Aiwu Zhou   +4 more
doaj   +1 more source

An overview of the serpin superfamily.

Genome biology, 2006
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in ...
James C. Whisstock, James C. Whisstock, Qingwei Zhang, Sheena McGowan, Robert N. Pike, Gary A. Silverman, Christopher G. Langendorf, Phillip I. Bird, Wilson Wong, Ruby H. P. Law, Carlos J. Rosado, Ashley M. Buckle   +11 more
openaire   +3 more sources