Results 21 to 30 of about 34,502 (251)

Serpin–4 Facilitates Baculovirus Infection by Inhibiting Melanization in Asian Corn Borer, Ostrinia furnacalis (Guenée)

Frontiers in Immunology, 2022
Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji, Dongxu Shen, Dongxu Shen, Dongxu Shen, Shasha Zhang, Lei Wang, Chunju An   +6 more
doaj   +1 more source

The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop [PDF]

, 2015
Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by ...
Caccia, Sonia, Manno, Mauro, Martorana, Vincenzo, MIRANDA BANOS, MARIA ELENA, Moriconi, Claudia, Noto, Rosina, Raccosta, Samuele, Randazzo, Loredana   +7 more
core   +1 more source

Recombinant Trichinella pseudospiralis Serine Protease Inhibitors Alter Macrophage Polarization In Vitro

Frontiers in Microbiology, 2017
During parasite infection, serine protease inhibitors secreted by parasites play important roles in suppressing host defenses. However, the mechanism of immune regulation is unclear.
Ning Xu, Xiaolei Liu, Bin Tang, Libo Wang, Hai N. Shi, Pascal Boireau, Pascal Boireau, Mingyuan Liu, Mingyuan Liu, Xue Bai   +9 more
doaj   +1 more source

Expression of SERPINA3s in cattle: focus on bovSERPINA3-7 reveals specific involvement in skeletal muscle [PDF]

Open Biology, 2015
α1-Antichymotrypsin is encoded by the unique SERPINA3 gene in humans, while it is encoded by a cluster of eight closely related genes in cattle. BovSERPINA3 proteins present a high degree of similarity and significant divergences in the reactive centre ...
Antoine Péré-Brissaud, Xavier Blanchet, Didier Delourme, Patrick Pélissier, Lionel Forestier, Arnaud Delavaud, Nathalie Duprat, Brigitte Picard, Abderrahman Maftah, Laure Brémaud   +9 more
doaj   +1 more source

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

Molecules, 2020
Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously ...
Catherine A. Tindall, Sebastian Dommel, Veronika Riedl, David Ulbricht, Stefanie Hanke, Norbert Sträter, John T. Heiker   +6 more
doaj   +1 more source

Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules

Frontiers in Immunology, 2023
Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host’s hemostatic
Adéla Chlastáková, Adéla Chlastáková, Barbora Kaščáková, Jan Kotál, Helena Langhansová, Michail Kotsyfakis, Ivana Kutá Smatanová, Lucas Tirloni, Jindřich Chmelař   +8 more
doaj   +1 more source

Host-Parasite Relationships in Porcine Ascariosis: Anticoagulant Potential of the Third Larval Stage of Ascaris suum as a Possible Survival Mechanism

Animals, 2021
In order to evade the response of their hosts, helminth parasites have evolved precise and highly regulated mechanisms, including migration strategies of the larval stages. In regard to porcine ascariosis caused by Ascaris suum, its infective third-stage
Alicia Diosdado, Fernando Simón, Rodrigo Morchón, Javier González-Miguel   +3 more
doaj   +1 more source

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity [PDF]

, 2015
SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood.
Biasiolo, Alessandra, Cannito, Stefania, Cillo, Umberto, Fasolato, Silvano, Gatta, Angelo, Martini, Andrea, Martini, Andrea, Morello, Elisabetta, Parola, Maurizio, Pontisso, Patrizia, Quarta, SANTINA MARIA, Ruvoletto, Mariagrazia, Simonato, Davide, Terrin, Liliana, Turato, Cristian, Villano, Gianmarco, Zanus, Giacomo   +16 more
core   +2 more sources

Interaction of subtilisins with serpins [PDF]

Protein Science, 1996
AbstractSerpins are well‐characterized inhibitors of the chymotrypsin family serine proteinases. We have investigated the interaction of two serpins with members of the subtilisin family, proteinases that possess a similar catalytic mechanism to the chymotrypsins, but a totally different scaffold.
T, Komiyama, H, Grøn, P A, Pemberton, G S, Salvesen   +3 more
openaire   +2 more sources

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]

, 2015
A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV, Haq, I, Irving, JA, Kotov, VR, Lomas, DA, Miranda, E, Motamedi-Shad, N, Perez, J   +7 more
core   +4 more sources