Results 21 to 30 of about 23,239 (235)

Serpin–4 Facilitates Baculovirus Infection by Inhibiting Melanization in Asian Corn Borer, Ostrinia furnacalis (Guenée)

Frontiers in Immunology, 2022
Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji, Dongxu Shen, Dongxu Shen, Dongxu Shen, Shasha Zhang, Lei Wang, Chunju An   +6 more
doaj   +1 more source

Deciphering the phylogenetic history of neuroserpin orthologs across metazoans by analysis of synteny and rare genomic characters [PDF]

, 2008
The superfamily of serine proteinase inhibitors (serpins) is involved in wide arrays of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression. The average protein
Hermann Ragg, Abhishek Kumar
core   +1 more source

Recombinant Trichinella pseudospiralis Serine Protease Inhibitors Alter Macrophage Polarization In Vitro

Frontiers in Microbiology, 2017
During parasite infection, serine protease inhibitors secreted by parasites play important roles in suppressing host defenses. However, the mechanism of immune regulation is unclear.
Ning Xu, Xiaolei Liu, Bin Tang, Libo Wang, Hai N. Shi, Pascal Boireau, Pascal Boireau, Mingyuan Liu, Mingyuan Liu, Xue Bai   +9 more
doaj   +1 more source

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

Molecules, 2020
Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously ...
Catherine A. Tindall, Sebastian Dommel, Veronika Riedl, David Ulbricht, Stefanie Hanke, Norbert Sträter, John T. Heiker   +6 more
doaj   +1 more source

Serpins: the uncut version [PDF]

Structure, 1994
The structure of active antithrombin, the first active serpin to be solved, sheds new light on the conformational forms of this important class of inhibitor.
E J, Goldsmith, J, Mottonen
openaire   +2 more sources

Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis

Journal of Translational Medicine, 2022
Background Helicobacter pylori (H. pylori) can disrupt the tight junctions between gastric epithelial cells and penetrate the intercellular spaces acting on epithelial cells, normal fibroblasts (NFs), and cancer-associated fibroblasts (CAFs), but their ...
Xueshu Chen, Wei Chen, Yan Zhao, Qinrong Wang, Wenling Wang, Yining Xiang, Hang Yuan, Yuan Xie, Jianjiang Zhou   +8 more
doaj   +1 more source

Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules

Frontiers in Immunology, 2023
Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host’s hemostatic
Adéla Chlastáková, Adéla Chlastáková, Barbora Kaščáková, Jan Kotál, Helena Langhansová, Michail Kotsyfakis, Ivana Kutá Smatanová, Lucas Tirloni, Jindřich Chmelař   +8 more
doaj   +1 more source

Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes [PDF]

, 2009
Ragg H, Kumar A, Köster K, et al. Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes. BMC Evolutionary Biology.
Hermann Ragg, Prib, Natalie, Krüger, Olaf, Ragg Hermann, Katharina Köster, Yunjie Wang, Kumar Abhishek, Bentele, Caterina, Wang Yunjie, Köster, Katharina, Caterina Bentele, Prib Natalie, Kumar, Abhishek, Frese, Marc-Andre, Olaf Krüger, Abhishek Kumar, Ragg, Hermann, Krüger Olaf, Marc-André Frese, Bentele Caterina, Wang, Yunjie, Köster Katharina, Frese Marc-André, Natalie Prib   +23 more
core   +1 more source

Host-Parasite Relationships in Porcine Ascariosis: Anticoagulant Potential of the Third Larval Stage of Ascaris suum as a Possible Survival Mechanism

Animals, 2021
In order to evade the response of their hosts, helminth parasites have evolved precise and highly regulated mechanisms, including migration strategies of the larval stages. In regard to porcine ascariosis caused by Ascaris suum, its infective third-stage
Alicia Diosdado, Fernando Simón, Rodrigo Morchón, Javier González-Miguel   +3 more
doaj   +1 more source

Expression patterns and synergistic regulation analysis of serpin-1a and serpin-6.

, 2023
B. mori serpin-1 and -6 mRNA and protein levels in in fat body (A) and hemolymph (B) from different developmental stages. The fat body and hemolymph from day 3 of the fourth-instar larvae to day 1 of the pupal stage were collected for RNA isolation and ...
Jiahui Xu (3156327), Ping Zhao (47228), Zhangchen Tang (17200393), Qingyou Xia (47221), Wei Wang (17594), Xiaotong Sun (6535064), Xin Tang (134573), Pengchao Guo (720523), Huawei Liu (2585974), Lingyan Wang (176742), Luoling Wang (16384833), Yang Cao (53545)   +11 more
core   +1 more source