Results 41 to 50 of about 23,239 (235)

Effects of serpin-1 knockout on serpin-6 expression and immune homeostasis in silkworm under immune challenge.

, 2023
(A) Wild-type (WT) and serpin-1 knockout (serpin-1-/-) individuals were respectively injected with Escherichia coli, Pseudomonas aeruginosa, Micrococcus luteus, or Enterococcus mundtii; survival curves were plotted until 72 h post-infection.
Jiahui Xu (3156327), Ping Zhao (47228), Zhangchen Tang (17200393), Qingyou Xia (47221), Wei Wang (17594), Xiaotong Sun (6535064), Xin Tang (134573), Pengchao Guo (720523), Huawei Liu (2585974), Lingyan Wang (176742), Luoling Wang (16384833), Yang Cao (53545)   +11 more
core   +1 more source

Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis

Frontiers in Cardiovascular Medicine, 2022
Appropriate activation of coagulation requires a balance between procoagulant and anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis.
Steven P. Grover, Nigel Mackman
doaj   +1 more source

Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

Frontiers in Cardiovascular Medicine, 2021
Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential
Elsa P. Bianchini, Claire Auditeau, Mahita Razanakolona, Marc Vasse, Marc Vasse, Delphine Borgel, Delphine Borgel   +6 more
doaj   +1 more source

Thrombin inhibition by the serpins [PDF]

Journal of Thrombosis and Haemostasis, 2013
Thrombin is the central protease in the blood coagulation network. It has multiple substrates and cofactors, and it appears that four serpins are responsible for inhibiting the thrombin produced in haemostasis and thrombosis. Structural studies conducted over the last 10 years have resolved how thrombin recognises these serpins with the aid of ...
openaire   +2 more sources

Reactive centre loop dynamics and serpin specificity [PDF]

, 2019
Serine proteinase inhibitors (serpins), typically fold to a metastable native state and undergo a major conformational change in order to inhibit target proteases.
Porebski, Benjamin T., McGowan, Sheena, Buckle, Ashley M., Marijanovic, Emilia M., Costa, Mauricio G.S., Hoke, David E., Fodor, James, Kass, Itamar, Riley, Blake T.   +8 more
core   +1 more source

Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection

EMBO Molecular Medicine, 2023
SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic ...
Liqiang Zhang, Yize Henry Li, Karen Kibler, Simona Kraberger, Arvind Varsani, Julie Turk, Nora Elmadbouly, Emily Aliskevich, Laurel Spaccarelli, Bereket Estifanos, Junior Enow, Isabela Rivabem Zanetti, Nicholas Saldevar, Efrem Lim, Jessika Schlievert, Kyle Browder, Anjali Wilson, Fernando Arcos Juan, Aubrey Pinteric, Aman Garg, Henna Monder, Rohan Saju, Savanah Gisriel, Bertram Jacobs, Timothy L Karr, Esther Borges Florsheim, Vivek Kumar, John Wallen, Masmudur Rahman, Grant McFadden, Brenda G Hogue, Alexandra R Lucas   +31 more
doaj   +1 more source

Characterization and functional analysis of the serpin-10 gene from oak silkworm, Antheraea pernyi (Lepidoptera: Saturniidae)

European Journal of Entomology, 2017
Serpin is a broadly distributed superfamily of proteins that have a crucial role in regulating various immune reactions. Herein we identified a serpin-10 gene from Antheraea pernyi that encodes a 1557 amino acid residue protein with a predicted molecular
Saima KAUSAR, Cen QIAN, Muhammad Nadeem ABBAS, Bao-Jian ZHU, Ya LIU, Lei WANG, Guo-Qing WEI, Yu SUN, Chao-Liang LIU   +8 more
doaj   +1 more source

Species-Specific Serological Detection for Schistosomiasis by Serine Protease Inhibitor (SERPIN) in Multiplex Assay. [PDF]

PLoS Neglected Tropical Diseases, 2015
Both Schistosoma mansoni and Schistosoma haematobium cause schistosomiasis in sub-Saharan Africa. We assessed the diagnostic value of selected Schistosoma antigens for the development of a multiplex serological immunoassay for sero-epidemiological ...
Chihiro Tanigawa, Yoshito Fujii, Masashi Miura, Samson Muuo Nzou, Anne Wanjiru Mwangi, Sachiyo Nagi, Shinjiro Hamano, Sammy M Njenga, Evaristus Chibunna Mbanefo, Kenji Hirayama, Matilu Mwau, Satoshi Kaneko   +11 more
doaj   +1 more source

Serpins in theCaenorhabditis elegans genome [PDF]

Proteins: Structure, Function, and Genetics, 1999
Data mining in genome sequences can identify distant homologues of known protein families, and is most powerful if solved structures are available to reveal the three-dimensional implications of very dissimilar sequences. Here we describe putative serpin sequences identified with very high statistical significance in the Caenorhabditis elegans genome ...
J C, Whisstock, J A, Irving, S P, Bottomley, R N, Pike, A M, Lesk   +4 more
openaire   +2 more sources

Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini

Pathogens
Serine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang, Wansika Phadungsil, Amornrat Geadkaew-Krenc, Rudi Grams   +3 more
doaj   +1 more source