Results 41 to 50 of about 34,502 (251)
Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
core +1 more source
A genomic analysis and transcriptomic atlas of gene expression in Psoroptes ovis reveals feeding- and stage-specific patterns of allergen expression [PDF]
, 2019 Background: Psoroptic mange, caused by infestation with the ectoparasitic mite, Psoroptes ovis, is highly contagious, resulting in intense pruritus and represents a major welfare and economic concern for the livestock industry Worldwide.
Bartley, Kathryn +11 more
core +2 more sources
Arginine Inhibits Serpins [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2007 Serine protease inactivators (serpins) are important regulators in biochemistry. Often it is necessary to block the serpin action, that is, to stabilize the sample. The guanidine group of arginine is the ligand for the active center pocket of many serine proteases.
openaire +2 more sources
Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis
Frontiers in Cardiovascular Medicine, 2022 Appropriate activation of coagulation requires a balance between procoagulant and anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis.
Steven P. Grover, Nigel Mackman
doaj +1 more source
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
EMBO Molecular Medicine, 2023 SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic ...
Liqiang Zhang +31 more
doaj +1 more source
Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders
Frontiers in Cardiovascular Medicine, 2021 Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential
Elsa P. Bianchini +6 more
doaj +1 more source
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich +2 more
core +1 more source
Thrombin inhibition by the serpins [PDF]
Journal of Thrombosis and Haemostasis, 2013 Thrombin is the central protease in the blood coagulation network. It has multiple substrates and cofactors, and it appears that four serpins are responsible for inhibiting the thrombin produced in haemostasis and thrombosis. Structural studies conducted over the last 10 years have resolved how thrombin recognises these serpins with the aid of ...
openaire +2 more sources
Frustration in Biomolecules [PDF]
, 2013 Biomolecules are the prime information processing elements of living matter. Most of these inanimate systems are polymers that compute their structures and dynamics using as input seemingly random character strings of their sequence, following which they
Ferreiro, Diego U. +2 more
core +2 more sources