Results 31 to 40 of about 23,239 (235)
Interaction of subtilisins with serpins [PDF]
Protein Science, 1996 AbstractSerpins are well‐characterized inhibitors of the chymotrypsin family serine proteinases. We have investigated the interaction of two serpins with members of the subtilisin family, proteinases that possess a similar catalytic mechanism to the chymotrypsins, but a totally different scaffold.
T, Komiyama +3 more
openaire +2 more sources
Polymers and inflammation: disease mechanisms of the serpinopathies [PDF]
, 2008 Members of the serpin (serine proteinase inhibitor) superfamily play a central role in the control of inflammatory, coagulation, and fibrinolytic cascades.
David A. Lomas +4 more
core +1 more source
Serpin Signatures in Prion and Alzheimer's Diseases [PDF]
, 2022 Serpins represent the most broadly distributed superfamily of proteases inhibitors. They contribute to a variety of physiological functions and any alteration of the serpin-protease equilibrium can lead to severe consequences.
Ferracin C +12 more
core +3 more sources
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections
mBio, 2022 The coronavirus disease 2019, COVID-19, is a complex disease with a wide range of symptoms from asymptomatic infections to severe acute respiratory syndrome with lethal outcome. Individual factors such as age, sex, and comorbidities increase the risk for
Ebba Rosendal +14 more
doaj +1 more source
Serpins in arthropod biology [PDF]
Seminars in Cell & Developmental Biology, 2017 Serpins are the largest known family of serine proteinase inhibitors and perform a variety of physiological functions in arthropods. Herein, we review the field of serpins in arthropod biology, providing an overview of current knowledge and topics of interest.
David A, Meekins +2 more
openaire +2 more sources
Identification of new genes associated with melanoma [PDF]
, 2011 Purpose: Repeated failures in melanoma therapy made clear that the molecular mechanisms leading to melanoma are still poorly understood. Here, we aim to provide a more comprehensive understanding of the transcriptional profiles and signaling pathways ...
Mauerer, Andreas
core +1 more source
Purification and inhibitory activity assay for serpin-1a and serpin-6.
, 2023 (A and B) Purification and inhibitory activity assays of serpin-1a. (C, D) Purification and inhibitory activity assays for serpin-6. M, Marker; CL, Crude protein liquid; FT, flow-through; BB, elution fraction of binding buffer; 20–1000, elution fraction ...
Jiahui Xu (3156327) +11 more
core +1 more source
Necrosis and the Serpin Under't [PDF]
Developmental Cell, 2007 Caspase proteases play essential roles in apoptotic cell death, while other proteases are active in necrotic cell death. In a recent paper in Cell, Luke et al. (2007) present findings demonstrating that a gene believed to be a natural protease inhibitor may have a role in preventing necrosis.
Abraham, Mary C., Shaham, Shai
openaire +2 more sources
CRISPR/Cas9-mediated serpin-1 knockout.
, 2023 (A) Schematic diagram of serpin-1 gRNA location. Screening strategy for serpin-1 knockout (serpin-1-/-) homozygotes (B) and genomic DNA sequencing (C). (TIF)
Jiahui Xu (3156327) +11 more
core +1 more source
Control of granzymes by serpins [PDF]
Cell Death & Differentiation, 2009 Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
D, Kaiserman, P I, Bird
openaire +2 more sources