Results 11 to 20 of about 23,239 (235)

Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera. [PDF]

PLoS Pathogens, 2017
Melanization, an important insect defense mechanism, is mediated by clip-domain serine protease (cSP) cascades and is regulated by serpins. Here we show that proteolytic activation of prophenoloxidase (PPO) and PO-catalyzed melanization kill the ...
Chuanfei Yuan, Longsheng Xing, Manli Wang, Xi Wang, Mengyi Yin, Qianran Wang, Zhihong Hu, Zhen Zou   +7 more
doaj   +2 more sources

Serpin B9 is Highly Expressed in Lung Adenocarcinoma and is Associated with Progression-Free Survival [PDF]

Journal of Inflammation Research
Yue Fang,1,2,* Yi Yue,3,* Sensen Hao,1 Ying Zhang,4 Nan Liu,1 Shengling Wang,1 Yan Li,1 Hongzhi Wang1 1Galactophore Oncology Center, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei City, Anhui Province, People’s Republic of China ...
Fang Y, Yue Y, Hao S, Zhang Y, Liu N, Wang S, Li Y, Wang H   +7 more
doaj   +1 more source

Carbohydrate-controlled serine protease inhibitor (serpin) production in Bifidobacterium longum subsp. longum

Scientific Reports, 2021
The Serine Protease Inhibitor (serpin) protein has been suggested to play a key role in the interaction of bifidobacteria with the host. By inhibiting intestinal serine proteases, it might allow bifidobacteria to reside in specific gut niches.
S. Duboux, M. Golliard, J. A. Muller, G. Bergonzelli, C. J. Bolten, A. Mercenier, M. Kleerebezem   +6 more
doaj   +1 more source

rDromaserpin: A Novel Anti-Hemostatic Serpin, from the Salivary Glands of the Hard Tick Hyalomma dromedarii

Toxins, 2021
Hemostatic disorders are caused either by platelet-related dysfunctions, defective blood coagulation, or by a combination of both, leading to an increased susceptibility to cardiovascular diseases (CVD) and other related illnesses. The unique specificity
Hajer Aounallah, Melissa Regina Fessel, Mauricio Barbugiani Goldfeder, Eneas Carvalho, Chaima Bensaoud, Ana Marisa Chudzinski-Tavassi, Ali Bouattour, Youmna M’ghirbi, Fernanda Faria   +8 more
doaj   +1 more source

Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner.

PLoS Neglected Tropical Diseases, 2020
There is an urgent need for the development of new, improved vaccine adjuvants against T. spiralis infection. Polysaccharides are effective, safe, and biodegradable as adjuvant.
Xuemin Jin, Xiaolei Liu, Jing Ding, Lixiao Zhang, Yaming Yang, Xuelin Wang, Yong Yang, Mingyuan Liu   +7 more
doaj   +1 more source

Ancestry and evolution of a secretory pathway serpin [PDF]

, 2008
Kumar A, Ragg H. Ancestry and evolution of a secretory pathway serpin. BMC Evolutionary Biology. 2008;8(1): 250.Background:The serpin (serine protease inhibitor) superfamily constitutes a class of functionally highly diverse proteins usually encompassing
Hermann Ragg, Abhishek Kumar, Ragg, Hermann, Ragg Hermann, Kumar Abhishek, Kumar, Abhishek   +5 more
core   +1 more source

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia. [PDF]

, 2012
The prevalence of Parkinson's disease (PD) increases with age. Up to 50% of PD show cognitive decline in terms of a mild cognitive impairment already in early stages that predict the development of dementia, which can occur in up to 80% of PD patients ...
Hans A Kretzschmar, Manuela Neumann, Hans A. Kretzschmar (46374), Neumann, Manuela, Soininen, H., Saskia Tawfik, Hengerer, B., Herukka, Sanna-Kaisa, Kulaksiz, H., Ferger, B., Tawfik, Saskia, Steinacker, Petra, Steinacker, P., Lenter, M., Manuela Neumann (120819), Jesse, S., Lehnert, S., Kulaksiz, Hasan, Bastian Hengerer, Neumann, M., Christine A F von Arnim, Markus Otto (120832), Otto, Markus, Christine A. F. von Arnim (120817), Lucilla Parnetti (120805), Sarah Jesse (120792), Parnetti, Lucilla, Hilkka Soininen, Jahn, Olaf, Wiltfang, Jens, Hilkka Soininen (120808), Jahn, O., Petra Steinacker (120812), Tumani, Hayrettin, Lenter, Martin, Kretzschmar, Hans A., Tumani, H., Otto, M., Boris Ferger, Hayrettin Tumani, Martin Lenter, Hengerer, Bastian, Saskia Tawfik (120814), Wiltfang, J., Olaf Jahn, Lucilla Parnetti, Soininen, Hilkka, Bastian Hengerer (120831), Sanna-Kaisa Herukka, Olaf Jahn (120801), Martin Lenter (120825), von Arnim, Christine A. F., Markus Otto, von Arnim, C., Stefan Lehnert, Petra Steinacker, Hayrettin Tumani (120815), Arnim, Christine A. F. von, Hasan Kulaksiz, Ferger, Boris, Stefan Lehnert (120797), Jens Wiltfang (44073), Sanna-Kaisa Herukka (120810), Jens Wiltfang, Kretschmar, H., Parnetti, L., Hasan Kulaksiz (120823), Boris Ferger (120827), Herukka, S., Jesse, Sarah, Tawfik, S., Lehnert, Stefan, Sarah Jesse   +72 more
core   +1 more source

Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction

JACC: Basic to Translational Science, 2017
Low-density lipoprotein receptor–related protein-1 (LRP1) is a ubiquitous membrane receptor functioning as a scavenger and regulatory receptor, inducing anti-inflammatory and prosurvival signals. Based on the known structure–activity of the LRP1 receptor
Stefano Toldo, PhD, Dana Austin, MS, Adolfo G. Mauro, MS, Eleonora Mezzaroma, PhD, Benjamin W. Van Tassell, PharmD, Carlo Marchetti, PhD, Salvatore Carbone, MS, Soren Mogelsvang, PhD, Cohava Gelber, PhD, Antonio Abbate, MD, PhD   +9 more
doaj   +1 more source

Delving into Vertebrate Serpins for Understanding their Evolution [PDF]

, 2009
The superfamily of serine proteinase inhibitors (serpins) is involved in an array of fundamental biological processes such as blood coagulation, cell differentiation, cell migration, complement activation, embryo implantation, fibrinolysis, angiogenesis,
Abhishek Kumar
core   +1 more source

Expression of SERPINA3s in cattle: focus on bovSERPINA3-7 reveals specific involvement in skeletal muscle [PDF]

Open Biology, 2015
α1-Antichymotrypsin is encoded by the unique SERPINA3 gene in humans, while it is encoded by a cluster of eight closely related genes in cattle. BovSERPINA3 proteins present a high degree of similarity and significant divergences in the reactive centre ...
Antoine Péré-Brissaud, Xavier Blanchet, Didier Delourme, Patrick Pélissier, Lionel Forestier, Arnaud Delavaud, Nathalie Duprat, Brigitte Picard, Abderrahman Maftah, Laure Brémaud   +9 more
doaj   +1 more source