Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism [PDF]
International Journal of COPD, 2015 Katrin Milger,1 Lesca Miriam Holdt,2 Daniel Teupser,2 Rudolf Maria Huber,1 Jürgen Behr,1 Nikolaus Kneidinger1 1Department of Internal Medicine V, University of Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research ...
Milger K +5 more
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COVID-19 Pathology Sheds Further Light on Balance between Neutrophil Proteases and Their Inhibitors [PDF]
Biomolecules, 2022 Excessive neutrophil influx and activation in lungs during infections, such as manifest during the ongoing SARS CoV-2 pandemic, have brought neutrophil extracellular traps (NETs) and the concomitant release of granule contents that damage surrounding ...
Vasuki Silva, Marko Radic
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BiologicsBackground and Objectives: The cytokine IL-6, methyltransferase NSD2, pro-protein convertase Furin, and growth factor receptor IGF-1R are essential factors in the proliferation of cancer cells.
Nassim Tassou +3 more
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Proteomics-based approach for differentiation of age-related macular degeneration sub-types [PDF]
Indian Journal of Ophthalmology, 2021 Purpose: Age-related macular degeneration (AMD) is one of the leading causes of irreversible central vision loss in the elderly population. The current study aims to find non-invasive prognostic biomarkers in the urine specimens of the AMD patients ...
Sivapriya Sivagurunathan +16 more
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COVID-19 Pathology Sheds New Light on Balance between Neutrophil Proteases and Their Inhibitors
, 2022 El carcinoma Escamoso de Cabeza y Cuello (CECC) es el sexto cáncer con mayor incidencia en países desarrollados. Dos terceras partes de los pacientes con Carcinoma Escamoso de Cabeza y Cuello (CECC) se diagnostican en estadios avanzados y no siempre responden al tratamiento habitual de quimioterapia combinada con cirugía o radioterapia.
Radic M, Silva VV.
europepmc +3 more sources
Alpha-1 Antitrypsin Deficiency Beyond COPD and Emphysema: A Narrative Review [PDF]
Medical SciencesBackground/Objectives: Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder classically associated with emphysema and COPD. However, emerging evidence indicates that its clinical spectrum extends to airway-predominant diseases such as ...
Lucia Pastoressa +6 more
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Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. [PDF]
, 2016 BACKGROUND: Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been ...
Bourne, S +10 more
core +4 more sources
Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance
Anais da Academia Brasileira de Ciências, 2021 Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and generates disability, which is characterized by generalized pain, fatigue, and functional decline.
LUÍSA P. JANSSEN +3 more
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Serpin Peptidase Inhibitor Clade A Member 1 (SerpinA1) Is a Novel Biomarker for Progression of Cutaneous Squamous Cell Carcinoma [PDF]
The American Journal of Pathology, 2011 The incidence of keratinocyte-derived nonmelanoma skin cancers is increasing worldwide because of cumulative recreational exposure to sunlight. At present, no specific molecular markers are available for assessing the progression of premalignant actinic keratoses to invasive cutaneous squamous cell carcinoma (SCC).
Kivisaari Atte +12 more
openaire +4 more sources
Biochemistry and Biophysics Reports, 2021 Obesity-induced endoplasmic reticulum (ER) stress contributes to low-grade chronic inflammation in adipose tissue and may cause metabolic disorders such as diabetes mellitus and dyslipidemia.
Yukari Ando +5 more
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