Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism [PDF]
International Journal of COPD, 2015 Katrin Milger,1 Lesca Miriam Holdt,2 Daniel Teupser,2 Rudolf Maria Huber,1 Jürgen Behr,1 Nikolaus Kneidinger1 1Department of Internal Medicine V, University of Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research ...
Milger K +5 more
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Correlation of SERPINA-1 Gene Over-Expression with Inhibition of Cell Proliferation and Modulation of the Expression of IL-6, Furin, and NSD2 Genes [PDF]
BiologicsBackground and Objectives: The cytokine IL-6, methyltransferase NSD2, pro-protein convertase Furin, and growth factor receptor IGF-1R are essential factors in the proliferation of cancer cells.
Nassim Tassou +3 more
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COVID-19 Pathology Sheds Further Light on Balance between Neutrophil Proteases and Their Inhibitors [PDF]
Biomolecules, 2022 Excessive neutrophil influx and activation in lungs during infections, such as manifest during the ongoing SARS CoV-2 pandemic, have brought neutrophil extracellular traps (NETs) and the concomitant release of granule contents that damage surrounding ...
Vasuki Silva, Marko Radic
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Proteomics-based approach for differentiation of age-related macular degeneration sub-types [PDF]
Indian Journal of Ophthalmology, 2021 Purpose: Age-related macular degeneration (AMD) is one of the leading causes of irreversible central vision loss in the elderly population. The current study aims to find non-invasive prognostic biomarkers in the urine specimens of the AMD patients ...
Sivapriya Sivagurunathan +16 more
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Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. [PDF]
, 2016 BACKGROUND: Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been ...
Bourne, S +10 more
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Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance
Anais da Academia Brasileira de Ciências, 2021 Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and generates disability, which is characterized by generalized pain, fatigue, and functional decline.
LUÍSA P. JANSSEN +3 more
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Biochemistry and Biophysics Reports, 2021 Obesity-induced endoplasmic reticulum (ER) stress contributes to low-grade chronic inflammation in adipose tissue and may cause metabolic disorders such as diabetes mellitus and dyslipidemia.
Yukari Ando +5 more
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The diuretic torasemide does not prevent aldosterone-mediated mineralocorticoid receptor activation in cardiomyocytes. [PDF]
PLoS ONE, 2013 Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid signaling is deleterious during the evolution of cardiac failure, as evidenced by the benefits
Basile Gravez +6 more
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Revista Colombiana de Obstetricia y Ginecología, 2011 Introducción: la preeclampsia constituye una causa importante de morbimortalidad materna y perinatal en el mundo. Su etiopatogenia es aún un enigma; sin embargo, los avances en genómica y proteómica prometen la identificación temprana de la enfermedad o ...
Augusto Valderrama-Aguirre +2 more
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Collagen constitutes about 12% in females and 17% in males of the total protein in mice
Scientific Reports, 2023 Collagen has been postulated to be the most abundant protein in our body, making up one-third of the total protein content in mammals. However, a direct assessment of the total collagen levels of an entire mammal to confirm this estimate is missing. Here
Katharina Tarnutzer +3 more
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