Results 11 to 20 of about 806 (131)
Pi∗S and Pi∗Z Alleles of SERPINA1 Gene Are Associated With Specific Variants of a BRD4-Independent Enhancer. [PDF]
Hum MutatAlpha‐1 antitrypsin deficiency (AATD) is a genetic disorder caused by specific variants in the SERPINA1 gene, which encodes AAT. The most common disease‐associated SERPINA1 variants are Pi ∗ S and Pi ∗ Z alleles, which cause moderate and severe AATD, respectively. Recent studies have reported the presence of a possible regulator of SERPINA gene cluster
Escuela-Escobar A +5 more
europepmc +2 more sources
Collagen constitutes about 12% in females and 17% in males of the total protein in mice
Scientific Reports, 2023 Collagen has been postulated to be the most abundant protein in our body, making up one-third of the total protein content in mammals. However, a direct assessment of the total collagen levels of an entire mammal to confirm this estimate is missing. Here
Katharina Tarnutzer +3 more
doaj +1 more source
Revista Colombiana de Obstetricia y Ginecología, 2011 Introducción: la preeclampsia constituye una causa importante de morbimortalidad materna y perinatal en el mundo. Su etiopatogenia es aún un enigma; sin embargo, los avances en genómica y proteómica prometen la identificación temprana de la enfermedad o ...
Augusto Valderrama-Aguirre +2 more
doaj +3 more sources
Characteristics of Patients Experiencing a Flare of Generalized Pustular Psoriasis: A Multicenter Observational Study [PDF]
, 2023 Background: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by recurrent episodes of flares. Characteristics of patients experiencing a flare are hardly described in a real-life setting. The aim of the study
Aldo Cuccia +18 more
core +3 more sources
Topical emollient prevents the development of atopic dermatitis and atopic march in mice
Experimental Dermatology, Volume 32, Issue 7, Page 1007-1015, July 2023., 2023 Abstract To investigate the effect of emollient on atopic march in a murine model of atopic dermatitis (AD). Following induction of AD with topical calcipotriol (MC903) and ovalbumin (OVA), one group of mice was treated topically with a linoleic acid‐ceramide‐containing emollient, while mice without emollient treatment served as disease controls. After
Jiayi Zhang +7 more
wiley +1 more source
The RNA‐binding protein Snd1/Tudor‐SN regulates hypoxia‐responsive gene expression
FASEB BioAdvances, Volume 5, Issue 5, Page 183-198, May 2023., 2023 Our results show that in normal growth conditions Snd1 is not a critical factor for mRNA transcription in the mouse and describe a function for Snd1 in hypoxia adaptation through negatively regulating hypoxia‐related miRNAs and hypoxia‐induced transcription consistent with a role as stress response regulator.
Juha Saarikettu +9 more
wiley +1 more source
A research on the mechanism of SERPINA3 promoting malignant progression and gemcitabine resistance of pancreatic cancer by inhibiting ferroptosis [PDF]
Zhongguo aizheng zazhiBackground and purpose: Members of the serine protease inhibitor (SERPIN) family can influence tumorigenesis, progression, and prognosis by modulating processes such as apoptosis, invasion, metastasis, and angiogenesis in tumor cells. However, their role
HE Yuan, GUO Juncheng, YE Zhibin, WANG Xiaohu, LI Haonan, HUANG Jingbiao
doaj +1 more source
Hepatology Communications, Volume 6, Issue 12, Page 3335-3348, December 2022., 2022 Schematic illustration of the proposed role of adipocyte PHB1 in HFD‐induced NAFLD. Abstract Adipose tissue dysfunction is closely associated with the development and progression of nonalcoholic fatty liver disease (NAFLD). Recent studies have implied an important role of prohibitin‐1 (PHB1) in adipose tissue function. In the current study, we aimed to
Xiaolin Wang +7 more
wiley +1 more source
Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report [PDF]
, 2009 Background AATD is one of the most common inherited disorders in the World. However, it is generally accepted that AATD in North African populations is not a risk factor for lung and/or liver disease, based on a number of small studies.
Chibani Jemni +11 more
core +1 more source
Advanced Science, Volume 9, Issue 27, September 23, 2022., 2022 Multimeric soluble angiotensin‐converting enzyme 2 (sACE2) generated via SunTag/MoonTag scaffolds enhanced neutralization capacity of monomeric sACE2 more than 100‐fold against pseudoviruses of variants of concern (VOC) and live severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2).
Alisan Kayabolen +21 more
wiley +1 more source