Results 11 to 20 of about 809 (140)

<i>Pi∗S</i> and <i>Pi∗Z</i> Alleles of <i>SERPINA1</i> Gene Are Associated With Specific Variants of a BRD4-Independent Enhancer. [PDF]

Hum Mutat
Alpha‐1 antitrypsin deficiency (AATD) is a genetic disorder caused by specific variants in the SERPINA1 gene, which encodes AAT. The most common disease‐associated SERPINA1 variants are Pi ∗ S and Pi ∗ Z alleles, which cause moderate and severe AATD, respectively. Recent studies have reported the presence of a possible regulator of SERPINA gene cluster
Escuela-Escobar A, Herrera-Luis E, Martín-González E, Hernández-Pérez JM, González Carracedo MA, Pérez JAP.   +5 more
europepmc   +2 more sources

Topical emollient prevents the development of atopic dermatitis and atopic march in mice

Experimental Dermatology, Volume 32, Issue 7, Page 1007-1015, July 2023., 2023
Abstract To investigate the effect of emollient on atopic march in a murine model of atopic dermatitis (AD). Following induction of AD with topical calcipotriol (MC903) and ovalbumin (OVA), one group of mice was treated topically with a linoleic acid‐ceramide‐containing emollient, while mice without emollient treatment served as disease controls. After
Jiayi Zhang, Xintian Xu, Xiaopan Wang, Li Zhang, Mengyan Hu, Yunchen Le, Lihong Chen, Jie Zheng   +7 more
wiley   +1 more source

The RNA‐binding protein Snd1/Tudor‐SN regulates hypoxia‐responsive gene expression

FASEB BioAdvances, Volume 5, Issue 5, Page 183-198, May 2023., 2023
Our results show that in normal growth conditions Snd1 is not a critical factor for mRNA transcription in the mouse and describe a function for Snd1 in hypoxia adaptation through negatively regulating hypoxia‐related miRNAs and hypoxia‐induced transcription consistent with a role as stress response regulator.
Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen   +9 more
wiley   +1 more source

A research on the mechanism of SERPINA3 promoting malignant progression and gemcitabine resistance of pancreatic cancer by inhibiting ferroptosis [PDF]

Zhongguo aizheng zazhi
Background and purpose: Members of the serine protease inhibitor (SERPIN) family can influence tumorigenesis, progression, and prognosis by modulating processes such as apoptosis, invasion, metastasis, and angiogenesis in tumor cells. However, their role
HE Yuan, GUO Juncheng, YE Zhibin, WANG Xiaohu, LI Haonan, HUANG Jingbiao
doaj   +1 more source

Characteristics of Patients Experiencing a Flare of Generalized Pustular Psoriasis: A Multicenter Observational Study [PDF]

, 2023
Background: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by recurrent episodes of flares. Characteristics of patients experiencing a flare are hardly described in a real-life setting. The aim of the study
Aldo Cuccia, Andrea Carugno, Angelo Valerio Marzano, Antonio Costanzo, Clara De Simone, Elena Pezzolo, Francesca Prignano, Francesca Satolli, Francesco Bellinato, Giampiero Girolomoni, Giovanni Damiani, Giuseppe Argenziano, Marco Romanelli, Marina Venturini, Martina Burlando, Matteo Megna, Paolo Dapavo, Paolo Gisondi, Stefano Piaserico   +18 more
core   +3 more sources

Deletion of adipocyte prohibitin 1 exacerbates high‐fat diet‐induced steatosis but not liver inflammation and fibrosis

Hepatology Communications, Volume 6, Issue 12, Page 3335-3348, December 2022., 2022
Schematic illustration of the proposed role of adipocyte PHB1 in HFD‐induced NAFLD. Abstract Adipose tissue dysfunction is closely associated with the development and progression of nonalcoholic fatty liver disease (NAFLD). Recent studies have implied an important role of prohibitin‐1 (PHB1) in adipose tissue function. In the current study, we aimed to
Xiaolin Wang, Seung‐Jin Kim, Yukun Guan, Richard Parker, Robim M. Rodrigues, Dechun Feng, Shelly C. Lu, Bin Gao   +7 more
wiley   +1 more source

Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo

Advanced Science, Volume 9, Issue 27, September 23, 2022., 2022
Multimeric soluble angiotensin‐converting enzyme 2 (sACE2) generated via SunTag/MoonTag scaffolds enhanced neutralization capacity of monomeric sACE2 more than 100‐fold against pseudoviruses of variants of concern (VOC) and live severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2).
Alisan Kayabolen, Ugur Akcan, Doğancan Özturan, Hivda Ulbegi‐Polat, Gizem Nur Sahin, Nareg Pinarbasi‐Degirmenci, Canan Bayraktar, Gizem Soyler, Ehsan Sarayloo, Elif Nurtop, Berna Ozer, Gulen Guney‐Esken, Tayfun Barlas, Ismail Selim Yildirim, Ozlem Dogan, Sercin Karahuseyinoglu, Nathan A. Lack, Mehmet Kaya, Cem Albayrak, Fusun Can, Ihsan Solaroglu, Tugba Bagci‐Onder   +21 more
wiley   +1 more source

SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

Respiratory Research, 2018
Background The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants.
Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Caroline Relton, Alexander J. Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W. Holloway, Nicole M. Probst-Hensch   +22 more
doaj   +1 more source

Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation. [PDF]

PLoS ONE, 2012
Certain concepts concerning EPO/EPOR action modes have been challenged by in vivo studies: Bcl-x levels are elevated in maturing erythroblasts, but not in their progenitors; truncated EPOR alleles that lack a major p85/PI3K recruitment site nonetheless ...
Seema Singh, Arvind Dev, Rakesh Verma, Anamika Pradeep, Pradeep Sathyanarayana, Jennifer M Green, Aishwarya Narayanan, Don M Wojchowski   +7 more
doaj   +1 more source

Changes on proteomic and metabolomic profile in serum of mice induced by chronic exposure to tramadol

Scientific Reports, 2021
Tramadol is an opioid used as an analgesic for treating moderate or severe pain. The long-term use of tramadol can induce several adverse effects. The toxicological mechanism of tramadol abuse is unclear. Limited literature available indicates the change
Shukun Jiang, Guojie Liu, Huiya Yuan, Enyu Xu, Wei Xia, Xiaoyu Zhang, Junting Liu, Lina Gao   +7 more
doaj   +1 more source