Respiratory Research, 2018 Background The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants.
Anna Beckmeyer-Borowko +22 more
doaj +1 more source
Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation. [PDF]
PLoS ONE, 2012 Certain concepts concerning EPO/EPOR action modes have been challenged by in vivo studies: Bcl-x levels are elevated in maturing erythroblasts, but not in their progenitors; truncated EPOR alleles that lack a major p85/PI3K recruitment site nonetheless ...
Seema Singh +7 more
doaj +1 more source
Scientific Reports, 2021 Tramadol is an opioid used as an analgesic for treating moderate or severe pain. The long-term use of tramadol can induce several adverse effects. The toxicological mechanism of tramadol abuse is unclear. Limited literature available indicates the change
Shukun Jiang +7 more
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Alpha-1-antitrypsin deficiency and bronchiectasis: A concomitance or a real association? [PDF]
, 2020 Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes’ predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are ...
Bocchino M. +4 more
core +1 more source
The role of alpha-1-antitrypsin protein in the pathogenesis of abdominal aortic aneurysm [PDF]
, 2018 Alpha-1-antitrypsin is a potent antiprotease playing an important role in maintaining protease-antiproteasebalance. It protects the structures of extracellular matrix against destruction by proteolytic enzymes.
Andziak, Piotr +5 more
core +2 more sources
Measurement tools to assess education and psychosocial support of pulmonary rehabilitation in people with chronic obstructive pulmonary disease: a systematic literature review [PDF]
, 2021 Introduction and objectives: Education and psychosocial support is a core component of pulmonary rehabilitation (PR). Nevertheless, measurement tools used to assess the effects of this component of PR have been scarcely investigated.
Agostinho, I. S. Mendes +2 more
core
Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets [PDF]
, 2022 Background: Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P.
Arman, Mònica +5 more
core +3 more sources
CILAIR-Based Secretome Analysis of Obese Visceral and Subcutaneous Adipose Tissues Reveals Distinctive ECM Remodeling and Inflammation Mediators [PDF]
, 2015 In the context of obesity, strong evidences support a distinctive pathological contribution of adipose tissue depending on its anatomical site of accumulation.
Alonso Lorenzo, Jana +8 more
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PLoS ONE, 2013 Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid signaling is deleterious during the evolution of cardiac failure, as evidenced by the benefits
Basile Gravez +6 more
doaj +1 more source
Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren’s syndrome condition
Autoimmunity, 2020 Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells. Although the loss of salivary gland function is a major manifestation observed in pSS, the factors that could promote these ...
Brij B. Singh +7 more
doaj +1 more source