The role of alpha-1-antitrypsin protein in the pathogenesis of abdominal aortic aneurysm [PDF]
, 2018 Alpha-1-antitrypsin is a potent antiprotease playing an important role in maintaining protease-antiproteasebalance. It protects the structures of extracellular matrix against destruction by proteolytic enzymes.
Andziak, Piotr +5 more
core +2 more sources
Alpha-1-antitrypsin deficiency and bronchiectasis: A concomitance or a real association? [PDF]
, 2020 Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes’ predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are ...
Bocchino M. +4 more
core +1 more source
Measurement tools to assess education and psychosocial support of pulmonary rehabilitation in people with chronic obstructive pulmonary disease: a systematic literature review [PDF]
, 2021 Introduction and objectives: Education and psychosocial support is a core component of pulmonary rehabilitation (PR). Nevertheless, measurement tools used to assess the effects of this component of PR have been scarcely investigated.
Agostinho, I. S. Mendes +2 more
core
Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets [PDF]
, 2022 Background: Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P.
Arman, Mònica +5 more
core +2 more sources
CILAIR-Based Secretome Analysis of Obese Visceral and Subcutaneous Adipose Tissues Reveals Distinctive ECM Remodeling and Inflammation Mediators [PDF]
, 2015 In the context of obesity, strong evidences support a distinctive pathological contribution of adipose tissue depending on its anatomical site of accumulation.
Alonso Lorenzo, Jana +8 more
core +1 more source
Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren’s syndrome condition
Autoimmunity, 2020 Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells. Although the loss of salivary gland function is a major manifestation observed in pSS, the factors that could promote these ...
Brij B. Singh +7 more
doaj +1 more source
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis
Toxics, 2020 E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a “healthy method” of tobacco consumption.
Anas A. Ashour +7 more
doaj +1 more source
PLoS Genetics, 2013 Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsin (AAT) in the blood.
Gian Andri Thun +42 more
doaj +1 more source
A challenging diagnosis of alpha-1-antitrypsin deficiency: identification of a patient with a novel F/Null phenotype [PDF]
, 2011 Alpha-1-antitrypsin (A1AT) deficiency is a genetic disease characterized by low levels and/or function of A1AT protein. A1AT deficiency can result in the development of COPD, liver disease, and certain skin conditions.
Banta, Erin +4 more
core +3 more sources
Incidence of alpha-1 antitrypsin Z and S alleles in patients with granulomatosis with polyangiitis — pilot study [PDF]
, 2013 WSTĘP: Wrodzony niedobór alfa-1 antytrypsyny jest jedną z trzech najczęstszych chorób genetycznych rasy kaukaskiej i wiąże się z istotnie wyższym ryzykiem rozwoju postępujących obturacyjnych chorób płuc, zwłaszcza przewlekłej obturacyjnej choroby płuc ...
Chorostowska-Wynimko, Joanna +4 more
core +2 more sources