Results 121 to 130 of about 11,907 (228)

Дефицит альфа-1-антитрипсина: генетические основы, эпидемиология, значение в развитии бронхо-легочной патологии [PDF]

, 2015
альфа-1-антитрипсинбронхолегочная дисплазияКРОВИ СЫВОРОТКАмутациягенная ...
Даниленко, Н. Г., Жигальцов, А. М., Жигальцова-Кучинская, О. А., Метельский, С. М., Нагорнов, И. В., Сивицкая, Л. Н.   +5 more
core  

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

PLoS Genetics, 2012
Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum metabolomic profiles.
Michael Inouye, Samuli Ripatti, Johannes Kettunen, Leo-Pekka Lyytikäinen, Niku Oksala, Pirkka-Pekka Laurila, Antti J Kangas, Pasi Soininen, Markku J Savolainen, Jorma Viikari, Mika Kähönen, Markus Perola, Veikko Salomaa, Olli Raitakari, Terho Lehtimäki, Marja-Riitta Taskinen, Marjo-Riitta Järvelin, Mika Ala-Korpela, Aarno Palotie, Paul I W de Bakker   +19 more
doaj   +1 more source

Butyrate modulating effects on pro-inflammatory pathways in human intestinal epithelial cells [PDF]

, 2017
Butyrate acts as energy source for intestinal epithelial cells and as key mediator of several immune processes, modulating gene expression mainly through histone deacetylation inhibition.
Amato, Felice, BERNI CANANI, Roberto, Calignano, Antonio, Castaldo, Giuseppe, Elce, A., Troncone, Riccardo, Zarrilli, F.   +6 more
core   +1 more source

Snail and serpinA1 promote tumor progression and predict prognosis in colorectal cancer

Oncotarget, 2015
The role of Snail and serpin peptidase inhibitor clade A member 1 (serpinA1) in tumorigenesis has been previously identified. However, the exact role and mechanism of these proteins in progression of colorectal cancer (CRC) are controversial. In this study, we investigated the role of Snail and serpinA1 in colorectal cancer (CRC) and examined the ...
Chae Hwa, Kwon, Hye Ji, Park, Jin Hwa, Choi, Ja Rang, Lee, Hye Kyung, Kim, Hong-Jae, Jo, Hyun Sung, Kim, Nahmgun, Oh, Geun Am, Song, Do Youn, Park   +9 more
openaire   +3 more sources

Knowledge-based gene expression classification via matrix factorization [PDF]

, 2008
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
A. M. Tomé, Affymetrix, Allison, Baldi, Barnhill, Bolstad, Breiman, Cardoso, Cardoso, Chen, D. Lutter, Diaz-Uriarte, Diaz-Uriarte, Dougherty, Dougherty, Dudoit, E. W. Lang, F. J. Theis, G. Schmitz, Galton, Galton, Golub, Guyon, Hochreiter, Irrizarry, Lee, Li, Liebermeister, Liu, Lutter, M. Stetter, Mangasarian, P. Gómez Vilda, P. Knollmüller, Pearson, Quackenbush, R. Schachtner, Saidi, Schachtner, Schachtner, Schölkopf, Simon, Spang, Talloen, Troyanskaya, Tusher, Wu, Wu   +47 more
core   +3 more sources

Serpina1 (α1-AT) is synthesized in the osteoblastic stem cell niche

Experimental Hematology, 2009
Previously, we identified Serpina1 as a potent inhibitor of hematopoietic stem and progenitor cell (HSC/HPC) mobilization. Serpina1 protein is found in the bone marrow (BM) extracellular fluid and concentrations are decreased during granulocyte colony-stimulating factor-induced HSC/HPC mobilization in mice.
Kuiperij, H.B., Pel, M. van, Rooij, K.E. de, Hoeben, R.C., Fibbe, W.E.   +4 more
openaire   +3 more sources

Towards a Molecular Systems Model of Coronary Artery Disease [PDF]

, 2014
Peer ...
Abraham, Gad, Bhalala, Oneil G., de Bakker, Paul I. W., Inouye, Michael, Ripatti, Samuli   +4 more
core   +2 more sources

Accurate Indentification of Pathogenic Mutations Conferring α1-Antitrypsin Deficiency by a Novel Multiplexed Molecular AssayTake-home Points

CHEST Pulmonary
Background: α1-Antitrypsin deficiency (AATD) is a common, underdiagnosed disease caused by mutations in the polymorphic SERPINA1 gene. AATD often causes COPD, other respiratory ailments, and severe liver disease.
Emily K. DeCurtis, BSc, Sharon K. Kuss-Duerkop, PhD, Iara M.P. Machado, PhD, Zoe P. Stewart, BSc, Matt Jackson, MS, Ellie Hasenohr, BSc, Jessica L. Crumby, BSc, Steve D. Groshong, MD, PhD, Claire M. Coeshott, PhD, Ronald J. Harbeck, PhD, James P. Woodrow, MD, Robert A. Sandhaus, MD, PhD, Yongbao Wang, PhD   +12 more
doaj   +1 more source

The influence of scaffold elasticity on germ layer specification of human embryonic stem cells [PDF]

, 2011
Mechanical forces are critical to embryogenesis, specifically, in the lineage-specification gastrulation phase, whereupon the embryo is transformed from a simple spherical ball of cells to a multi-layered organism, containing properly organized endoderm,
Anderson, Daniel Griffith, Karagiannis, Emmanouil, Langer, Robert S, Lee, Christopher Y., Levenberg, Shulamit, Zoldan, Janeta   +5 more
core   +1 more source

Evaluation of Congo red staining kit to determine proteinuria in preeclampsia [PDF]

, 2018
Plantear la posible utilidad del uso de la tinción de Rojo Congo en el diagnóstico de proteinuria en casos de preeclampsia.Introduction: Preeclampsia is characterised by the increased excretion of misfolding protein, attracted by a Diazo dye denominated ...
Angeles Vázquez, María de Jesús, Angeles Vázquez, María de Jesús, Fuentes Gutiérrez, Erika Karina, Fuentes Gutiérrez, Erika Karina, Mendieta Zerón, Hugo, Mendieta Zerón, Hugo, RODRIGUEZ CHAVEZ, JOSE LUIS, RODRIGUEZ CHAVEZ, JOSE LUIS   +7 more
core