Results 121 to 130 of about 10,821 (196)

Knowledge-based gene expression classification via matrix factorization [PDF]

, 2008
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
A. M. Tomé, Affymetrix, Allison, Baldi, Barnhill, Bolstad, Breiman, Cardoso, Cardoso, Chen, D. Lutter, Diaz-Uriarte, Diaz-Uriarte, Dougherty, Dougherty, Dudoit, E. W. Lang, F. J. Theis, G. Schmitz, Galton, Galton, Golub, Guyon, Hochreiter, Irrizarry, Lee, Li, Liebermeister, Liu, Lutter, M. Stetter, Mangasarian, P. Gómez Vilda, P. Knollmüller, Pearson, Quackenbush, R. Schachtner, Saidi, Schachtner, Schachtner, Schölkopf, Simon, Spang, Talloen, Troyanskaya, Tusher, Wu, Wu   +47 more
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The influence of scaffold elasticity on germ layer specification of human embryonic stem cells [PDF]

, 2011
Mechanical forces are critical to embryogenesis, specifically, in the lineage-specification gastrulation phase, whereupon the embryo is transformed from a simple spherical ball of cells to a multi-layered organism, containing properly organized endoderm,
Anderson, Daniel Griffith, Karagiannis, Emmanouil, Langer, Robert S, Lee, Christopher Y., Levenberg, Shulamit, Zoldan, Janeta   +5 more
core   +1 more source

Simultaneous Non-Negative Matrix Factorization for Multiple Large Scale Gene Expression Datasets in Toxicology [PDF]

, 2012
Non-negative matrix factorization is a useful tool for reducing the dimension of large datasets. This work considers simultaneous non-negative matrix factorization of multiple sources of data.
Crowther, Daniel, Haggart, D. R., Higham, Desmond J., Lee, Clare M., Miele, Gino, Mudaliar, Manikhandan A.V., Vass, J. Keith, Wolf, C. Roland   +7 more
core   +4 more sources

Accurate Indentification of Pathogenic Mutations Conferring α1-Antitrypsin Deficiency by a Novel Multiplexed Molecular AssayTake-home Points

CHEST Pulmonary
Background: α1-Antitrypsin deficiency (AATD) is a common, underdiagnosed disease caused by mutations in the polymorphic SERPINA1 gene. AATD often causes COPD, other respiratory ailments, and severe liver disease.
Emily K. DeCurtis, BSc, Sharon K. Kuss-Duerkop, PhD, Iara M.P. Machado, PhD, Zoe P. Stewart, BSc, Matt Jackson, MS, Ellie Hasenohr, BSc, Jessica L. Crumby, BSc, Steve D. Groshong, MD, PhD, Claire M. Coeshott, PhD, Ronald J. Harbeck, PhD, James P. Woodrow, MD, Robert A. Sandhaus, MD, PhD, Yongbao Wang, PhD   +12 more
doaj   +1 more source

Evaluation of Congo red staining kit to determine proteinuria in preeclampsia [PDF]

, 2018
Plantear la posible utilidad del uso de la tinción de Rojo Congo en el diagnóstico de proteinuria en casos de preeclampsia.Introduction: Preeclampsia is characterised by the increased excretion of misfolding protein, attracted by a Diazo dye denominated ...
Angeles Vázquez, María de Jesús, Angeles Vázquez, María de Jesús, Fuentes Gutiérrez, Erika Karina, Fuentes Gutiérrez, Erika Karina, Mendieta Zerón, Hugo, Mendieta Zerón, Hugo, RODRIGUEZ CHAVEZ, JOSE LUIS, RODRIGUEZ CHAVEZ, JOSE LUIS   +7 more
core  

Serpina1e mediates the exercise-induced enhancement of hippocampal memory

Abstract The exercise-induced enhancement of learning and memory is thought to be regulated by body‒brain interactions via secretory proteins in the blood plasma1,2. Given the prominent role that skeletal muscle plays during exercise, the beneficial effects of exercise on cognitive functions appear to be mediated by muscle-derived secretory ...
Hyungju Park, Hyunyoung Kim, Sanghee Shin, Jeongho Han, Jong-Seo Kim   +4 more
openaire   +1 more source

α1-Antitrypsin (SERPINA1; AAT; A1AT) [PDF]

Science-Business eXchange, 2010
openaire   +2 more sources

Serum α1-AT Levels and SERPINA1 Molecular Analysis in Breast Cancer: An Experimental and Computational Study

Diseases
Background/Objectives: Breast cancer (BC) is a heterogeneous disease with multifactorial origins, including environmental, genetic, and immunological factors.
Guadalupe Ávalos-Navarro, Luis A. Bautista-Herrera, Asbiel Felipe Garibaldi-Ríos, Ramiro Ramírez-Patiño, Marisol Gutiérrez-García, Perla Briseño-Álvarez, Luis Felipe Jave-Suárez, Emmanuel Reyes-Uribe, Martha Patricia Gallegos-Arreola   +8 more
doaj   +1 more source

SERPINA1 Gene [PDF]

, 2020
openaire   +1 more source

Case Report: Pseudomonas liver abscess in a previously healthy child with homozygous pathogenic S allele variant of the SERPINA1 gene

Frontiers in Immunology
BackgroundPyogenic liver abscess is an uncommon pediatric condition, and Pseudomonas aeruginosa represents a rare causative agent in otherwise healthy children. Such infections may signal an underlying inborn error of immunity. Alpha-1 antitrypsin (A1AT),
Sanya Thomas, Sanya Thomas, Alaric W. D’Souza, Alaric W. D’Souza, Alaric W. D’Souza, Musaab Alhezam, Musaab Alhezam, Craig D. Platt, Craig D. Platt, Ofer Levy, Ofer Levy, Ofer Levy   +11 more
doaj   +1 more source