Results 11 to 20 of about 10,821 (196)

Grass carp SERPINA1 inhibits GCRV infection through degrading CF2

Frontiers in Immunology, 2022
SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Yangyang Li, Yangyang Li, Liangming Chen, Liangming Chen, Rong Huang, Yangyu Li, Yangyu Li, Cheng Yang, Bin Gui, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Yaping Wang   +14 more
doaj   +5 more sources

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression. [PDF]

PLoS ONE, 2017
The main goal of the therapy with purified human plasma alpha1-antitrypsin (A1AT) is to increase A1AT levels and to prevent lungs from elastolytic activity in patients with PiZZ (Glu342Lys) A1AT deficiency-related emphysema.
Ahmad Karadagi, Helene Johansson, Helen Zemack, Sandeep Salipalli, Lisa-Mari Mörk, Kristina Kannisto, Carl Jorns, Roberto Gramignoli, Stephen Strom, Knut Stokkeland, Bo-Göran Ericzon, Danny Jonigk, Sabina Janciauskiene, Greg Nowak, Ewa C S Ellis   +14 more
doaj   +4 more sources

CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration [PDF]

Annals of Clinical and Translational Neurology, 2020
Objective SerpinA1 (alpha‐1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer’s disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal ...
Samir Abu‐Rumeileh, Steffen Halbgebauer, Petra Steinacker, Sarah Anderl‐Straub, Barbara Polischi, Albert C. Ludolph, Sabina Capellari, Piero Parchi, Markus Otto   +8 more
doaj   +4 more sources

SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency

Journal of Nucleic Acids, 2018
Alpha-1-antitrypsin (AAT) deficiency is a genetic disorder that produces inactive/defective AAT due to mutations in the SERPINA1 gene encoding AAT.
Brendan Connolly, Cleo Isaacs, Lei Cheng, Kirtika H. Asrani, Romesh R. Subramanian   +4 more
doaj   +3 more sources

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression [PDF]

Scientific Reports
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency.
F. N. U. Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey   +5 more
doaj   +2 more sources

A guide to selecting high-performing antibodies for Alpha-1-antitrypsin (UniProt ID: P01009) for use in western blot, immunoprecipitation and flow cytometry [version 1; peer review: 2 approved] [PDF]

F1000Research
Alpha-1-antitrypsin (A1AT), encoded by the SERPINA1 gene, is a circulating serine protease inhibitor that protects the lung from neutrophil elastase–mediated tissue damage.
Jemma Cooper, Katie Dixon, Bibek Gooptu, Harvinder Virk, Carolyn Jones, Michael Biddle   +5 more
doaj   +2 more sources

Fusion transcripts landscape in hepatocellular carcinoma and potential impact on the expression of fusion partners [PDF]

RNA Biology
Fusion transcripts (FTs) are RNA molecules, also known as chimeric transcripts, formed through chromosomal rearrangements or transcriptional processes, contributing to tumorigenesis.
Yasemin Öztemur Islakoğlu, Peyda Korhan, Leman Binokay, Barış Keleş, Ezgi Bağırsakçı, Meryem Uludağ Taşçıoğlu, Emine Şamdancı, Gökhan Karakülah, Neşe Atabey   +8 more
doaj   +2 more sources

SERPINA1 gene polymorphisms in a population‐based ALSPAC cohort [PDF]

Pediatric Pulmonology, 2019
Abstract Background There is an association between persistent preschool wheezing phenotypes and school‐age asthma. These wheezing/asthma phenotypes likely represent clinical entities having specific genetic risk factors.
David S. DeLuca, Edita Poluzioroviene, Vaida Taminskiene, Sabine Wrenger, Algirdas Utkus, Algirdas Valiulis, Tomas Alasevičius, John Henderson, Andrew Bush, Tobias Welte, Sabina Janciauskiene, Arunas Valiulis   +11 more
openaire   +7 more sources

Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity

Open Medicine, 2022
Serpin family A member 1 (SERPINA1) is expressed abundantly in gliomas and can predict unfavorable prognosis of patients with glioma. Studies have shown that nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (NQO1) can promote the ...
Liu Wenjun, Du Min, Wan Hongping, Yang Hao, Deng Xiaorong, Chen Yu, Zhang Qian   +6 more
doaj   +1 more source

SERPINA1 modulates expression of amyloidogenic transthyretin

Experimental Cell Research, 2020
Hereditary transthyretin amyloidosis (ATTR) is caused by amyloid deposition of misfolded transthyretin (TTR) in various tissues. Recently, reduction of circulating serum TTR, achieved via silencing oligonucleotides, was introduced as therapy of ATTR amyloidosis.
Christoph, Niemietz, Filipa, Bezerra, Maria Rosário, Almeida, Shuling, Guo, Brett P, Monia, Maria João, Saraiva, Paula, Schütz, Hartmut H-J, Schmidt, Andree, Zibert   +8 more
openaire   +2 more sources