Results 11 to 20 of about 11,907 (228)

Grass carp SERPINA1 inhibits GCRV infection through degrading CF2

Frontiers in Immunology, 2022
SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Yangyang Li, Yangyang Li, Liangming Chen, Liangming Chen, Rong Huang, Yangyu Li, Yangyu Li, Cheng Yang, Bin Gui, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Yaping Wang   +14 more
doaj   +5 more sources

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression. [PDF]

PLoS ONE, 2017
The main goal of the therapy with purified human plasma alpha1-antitrypsin (A1AT) is to increase A1AT levels and to prevent lungs from elastolytic activity in patients with PiZZ (Glu342Lys) A1AT deficiency-related emphysema.
Ahmad Karadagi, Helene Johansson, Helen Zemack, Sandeep Salipalli, Lisa-Mari Mörk, Kristina Kannisto, Carl Jorns, Roberto Gramignoli, Stephen Strom, Knut Stokkeland, Bo-Göran Ericzon, Danny Jonigk, Sabina Janciauskiene, Greg Nowak, Ewa C S Ellis   +14 more
doaj   +4 more sources

The phenotypic state of biallelic <i>SERPINA1 Q0</i> variants in α₁-antitrypsin deficiency. [PDF]

ERJ Open Res
Extract Rare variants play an important role in α1-antitrypsin deficiency (AATD) [1]. The Mediterranean area has a high variability for rare pathogenic variants, more frequently reported in Morocco, Portugal, Italy, Cyprus and Greece [1–4.] Among them ...
Papiris SA, Veith M, Ferrarotti I, Balduyck ML, Filosa A, Papaioannou AI, Lombard C, Ottaviani S, Rovina N, Kolilekas L, Zerimech F, Odou MF, Dechomet M, Prountzos S, Kontopoulou C, Kallieri M, Cuvelier A, le Rouzic O, Apollonatou V, Antonogiannaki EM, Osaba L, Entrena E, Traclet J, Weisenburger G, Cottin V, Vogelmeier C, Greulich T, Monti MC, Mornex JF, Manali ED.   +29 more
europepmc   +2 more sources

Role of Transcription Factor, LIM Homeobox 9 (LHX9) in Inflammatory Response by PGE2 and Thrombin in SERPINA1-Silencing Endometrial Stromal Cells. [PDF]

Mol Reprod Dev
Endometriosis is hypothesized to result from retrograde menstruation where cell debris including endometrial stromal cells (ESCs) travel through the fallopian tubes.
Kusama K, Ashihara M, Okita M, Yoshida K, Suzuki M, Suzuki K, Hosokawa R, Yoshie M, Kojima J, Mizuno Y, Ono M, Nishi H, Kajihara T, Tamura K.   +13 more
europepmc   +2 more sources

CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration [PDF]

Annals of Clinical and Translational Neurology, 2020
Objective SerpinA1 (alpha‐1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer’s disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal ...
Samir Abu‐Rumeileh, Steffen Halbgebauer, Petra Steinacker, Sarah Anderl‐Straub, Barbara Polischi, Albert C. Ludolph, Sabina Capellari, Piero Parchi, Markus Otto   +8 more
doaj   +4 more sources

Distribution of SERPINA1 gene mutations in patients with spontaneous pneumothorax: A cross-sectional study from a tertiary chest diseases clinic in Turkiye. [PDF]

Medicine (Baltimore)
Spontaneous pneumothorax (SP) is characterized by air accumulation between the visceral and parietal pleural layers without traumatic or iatrogenic causes.
Gegin S, Aksu EA, Temel NG, Yilmaz MA, Çelik D, Özdemir B, Özdemir L.   +6 more
europepmc   +2 more sources

Prognostic Value of SERPINA1 as a Biomarker for Poor Survival of Gliomas

Journal of Medical Sciences
Background: Glioma is a primary brain tumor known for its aggressive behavior and poor prognosis. Alpha-1 antitrypsin (SERPINA1) is a protein with a crucial role in regulating inflammatory processes in the body.
Nai-Jui Cheng, Hao-Yuan Hung, Tzu-Tsao Chung, Wen-Shin Song, Kun-Ting Hong, Dueng-Yuan Hueng   +5 more
doaj   +2 more sources

Prevalence of SERPINA1 mutations in a bronchiectasis cohort: implications of extended screening for alpha-1 antitrypsin deficiency [PDF]

Jornal Brasileiro de Pneumologia
Objective: To evaluate the prevalence of alpha-1 antitrypsin (AAT) variants through SERPINA1 genotyping in patients with non-cystic fibrosis bronchiectasis, and assess their clinical, functional and radiological characteristics.
Caroline Souza Sokoloski, Mariane Gonçalves Martynychen Canan, Cleverson Alex Leitão, Karin Mueller Storrer   +3 more
doaj   +2 more sources

Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression

Nature Communications
Lipodystrophy and obesity are associated with insulin resistance and metabolic syndrome accompanied by fat tissue dysregulation. Here, we show that serine protease inhibitor A1 (SerpinA1) expression in the liver is increased during recovery from ...
Shota Okagawa, Masaji Sakaguchi, Yuma Okubo, Yuri Takekuma, Motoyuki Igata, Tatsuya Kondo, Naoki Takeda, Kimi Araki, Bruna Brasil Brandao, Wei-Jun Qian, Yu-Hua Tseng, Rohit N. Kulkarni, Naoto Kubota, C. Ronald Kahn, Eiichi Araki   +14 more
doaj   +2 more sources

SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency

Journal of Nucleic Acids, 2018
Alpha-1-antitrypsin (AAT) deficiency is a genetic disorder that produces inactive/defective AAT due to mutations in the SERPINA1 gene encoding AAT.
Brendan Connolly, Cleo Isaacs, Lei Cheng, Kirtika H. Asrani, Romesh R. Subramanian   +4 more
doaj   +3 more sources