Results 41 to 50 of about 10,821 (196)

Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease. [PDF]

, 2017
Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced ...
Baye, Fitsum, Goswami, Chirayu Pankaj, Gurung, Ganga, Jackson, Isabel L., Katz, Barry P., Pavlovic, Radmila, Vujaskovic, Zeljko, Winans, Don, Zodda, Andrew   +8 more
core   +4 more sources

Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases [PDF]

, 2010
Background The SERPINA1, SERPINA3, and SERPINE2 genes, which encode antiproteases, have been proposed to be susceptible genes for of chronic obstructive pulmonary disease (COPD) and related phenotypes.
Koichi Fujimoto, Shinobu Ikeda, Tomio Arai, Noriko Tanaka, Toshio Kumasaka, Takeo Ishii, Kozui Kida, Masaaki Muramatsu, Motoji Sawabe   +8 more
core   +1 more source

Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia [PDF]

, 2020
BackgroundCritical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply.
A Carrizzo, A Limbourg, A Schroll, A Taguchi, A Zampetaki, AI Khan, AL Hemdahl, C Hu, C Kalka, C Seignez, C Xia, CH Yoon, D Sukmawati, DH Walter, DM Dunlea, DN Prater, E Chavakis, EB Jude, EC Watson, EE Vaughan, EL Simpson, F Du, F Sabatier, F Vinchi, FG Fowkes, FM Vega, G Cao, G Dragneva, GO Ouma, H Chen, HH Chopra, J Patel, J Rehman, J Zhang, JA Smith, JA Vizcaino, JG Tidball, JK Meisner, JL Anderson, JL Dong, JP Cooke, JX Yang, JY Kim, K Banno, K Funakoshi, L Bao, L Norgren, L Wu, LJ Druhan, M Hassanpour, M Qadura, M Rahmani, M Rigato, MS Conte, N Edwards, P Sangwung, Q Dai, Q Xie, R Donato, R Lara-Hernandez, R Tanaka, RC Savani, RH Lee, RJ Medina, RW Sprengers, S Hazarika, S Janciauskiene, S Nolan, SH Ko, SL Hsu, SM Krishna, SW Kim, T Asahara, UJ Sachs, V Abella, V Weel van, W Song, WC Shen, X Wang, X Zhou, Y Fujita, Y Ye, Z Yang   +82 more
core   +1 more source

Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers [PDF]

, 2007
SummaryObjectiveMesenchymal stem cells (MSCs) are a population of cells broadly discussed to support cartilage repair. The differentiation of MSCs into articular chondrocytes is, however, still poorly understood on the molecular level.
Boeuf, S., Steck, E., Pelttari, K., Hennig, T., Buneß, A., Benz, K., Witte, D., Sültmann, H., Poustka, A., Richter, W.   +9 more
core   +1 more source

Low Prevalence of Mild Alpha-1-Antitrypsin Deficiency in Hospitalized COVID-19-Patients

International Journal of General Medicine, 2022
David Nygren,1 Ulrica Mölstad,2 Hans Thulesius,2– 4 Magnus Hillman,5,6 Lars Mikael Broman,7,8 Hanan Tanash,9,10 Mona Landin-Olsson,5,6 Magnus Rasmussen,1 Maria Thunander2,6,11 1Division of Infection Medicine, Department of Clinical Sciences, Lund ...
Nygren D, Mölstad U, Thulesius H, Hillman M, Broman LM, Tanash H, Landin-Olsson M, Rasmussen M, Thunander M   +8 more
doaj  

Splicing variants of SERPINA1 gene in ovine milk: characterization of cDNA and identification of polymorphisms. [PDF]

PLoS ONE, 2013
The serine protease inhibitor, clade A, member 1 (SERPINA1) is the gene for a protein called alpha-1-antitrypsin (AAT), which is a member of the serine protease inhibitor (serpin) superfamily of proteins. By conformational change, serpins control several
Cinzia Marchitelli, Alessandra Crisà, Elisa Mostarda, Francesco Napolitano, Bianca Moioli   +4 more
doaj   +1 more source

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

, 2018
Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M, Biasiolo, A, Cappon, A, Cavicchioli, L, Codolo, G, Doria, A., Gatto, M, Ghirardello, A, Luisetto, R, Maggioni, G, Pontisso, P, Saccon, F, Venturini, R   +12 more
core   +2 more sources

A Novel SERPINA1 Mutation Causing Serum Alpha1-Antitrypsin Deficiency

PLoS ONE, 2012
Mutations in the SERPINA1 gene can cause deficiency in the circulating serine protease inhibitor α(1)-Antitrypsin (α(1)AT). α(1)AT deficiency is the major contributor to pulmonary emphysema and liver disease in persons of European ancestry, with a prevalence of 1 in 2500 in the USA.
Darren N Saunders, Elizabeth A Tindall, Robert F Shearer, Jacquelyn Roberson, Amy Decker, Jean Amos Wilson, Vanessa M Hayes   +6 more
openaire   +4 more sources

DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD [PDF]

, 2017
Background: Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs
Baier, Brian S., Li, Dongmei, Mazur, Witold, Rahman, Irfan, Sundar, Isaac K., Susiarjo, Martha, Yan, Li, Yin, Qiangzong   +7 more
core   +1 more source

Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema [PDF]

, 2014
Background: In this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an
Dzyubachyk, O.M. (Oleh), Essers, J. (Jeroen), Hawinkels, L.J.A.C. (Lukas ), Heijningen, P.M. (Paula ) van, Hendriks, R.W. (Rudi), Kanaar, R. (Roland), Kleinjan, A. (Alex), Luijtgaarden, K.M. (Koen) van de, Meijering, H.W. (Erik), Munck, A. (Anne) de, Nimwegen, M. (Menno) van, Pluijm, I. (Ingrid) van der, Ramnath, N.W.M. (Natasja ), Ridwan, R.Y. (Ruziedi Y.), Rottier, R.J. (Robbert), Rouwet, E.V. (Ellen), Spek, P.J. (Peter) van der, Swagemakers, S.M.A. (Sigrid), Thiel, B.S. (Bibi) van, Vermeij, M. (Marcel), Vliet, N. (Nicole) van, Yanagisawa, J.   +21 more
core   +1 more source