Results 41 to 50 of about 11,907 (228)

Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia [PDF]

, 2020
BackgroundCritical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply.
A Carrizzo, A Limbourg, A Schroll, A Taguchi, A Zampetaki, AI Khan, AL Hemdahl, C Hu, C Kalka, C Seignez, C Xia, CH Yoon, D Sukmawati, DH Walter, DM Dunlea, DN Prater, E Chavakis, EB Jude, EC Watson, EE Vaughan, EL Simpson, F Du, F Sabatier, F Vinchi, FG Fowkes, FM Vega, G Cao, G Dragneva, GO Ouma, H Chen, HH Chopra, J Patel, J Rehman, J Zhang, JA Smith, JA Vizcaino, JG Tidball, JK Meisner, JL Anderson, JL Dong, JP Cooke, JX Yang, JY Kim, K Banno, K Funakoshi, L Bao, L Norgren, L Wu, LJ Druhan, M Hassanpour, M Qadura, M Rahmani, M Rigato, MS Conte, N Edwards, P Sangwung, Q Dai, Q Xie, R Donato, R Lara-Hernandez, R Tanaka, RC Savani, RH Lee, RJ Medina, RW Sprengers, S Hazarika, S Janciauskiene, S Nolan, SH Ko, SL Hsu, SM Krishna, SW Kim, T Asahara, UJ Sachs, V Abella, V Weel van, W Song, WC Shen, X Wang, X Zhou, Y Fujita, Y Ye, Z Yang   +82 more
core   +1 more source

Identification of SERPINA1 promoting better prognosis in papillary thyroid carcinoma along with Hashimoto’s thyroiditis through WGCNA analysis

Frontiers in Endocrinology, 2023
BackgroundHashimoto’s thyroiditis (HT) is an autoimmune thyroid disease. Papillary thyroid carcinoma (PTC) is the most common endocrine cancer. In recent years the rate of coexistence between PTC and HT has increased but the relationship between them ...
Yihan Zhang, Xin Xie, Hong Zhou, Bingxin Li, Li Ding, Zhaogen Cai, Huaidong Song, Shuangxia Zhao, Huanbai Xu   +8 more
doaj   +1 more source

Tissue-specific gene silencing monitored in circulating RNA [PDF]

, 2013
Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that RNAi-mediated target gene ...
Bumcrot, David A., Chen, Qingmin, Gibbings, Derrick, Sah, Dinah W. Y., Sehgal, Alfica   +4 more
core   +1 more source

Global 5′-UTR RNA structure regulates translation of a SERPINA1 mRNA

Nucleic Acids Research, 2022
Abstract SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive pulmonary disease (COPD) and liver cirrhosis, and specific variants in the 5′-untranslated region (5′-UTR) are associated with COPD.
Philip J Grayeski, Chase A Weidmann, Jayashree Kumar, Lela Lackey, Anthony M Mustoe, Steven Busan, Alain Laederach, Kevin M Weeks   +7 more
openaire   +2 more sources

SERPINA1 Peptides in Urine as A Potential Marker of Preeclampsia Severity [PDF]

International Journal of Molecular Sciences, 2020
Preeclampsia (PE) is a multisystem disorder associated with pregnancy and its frequency varies from 5 to 20 percent of pregnancies. Although a number of preeclampsia studies have been carried out, there is no consensus about disease etiology and pathogenesis so far. Peptides of SERPINA1 (α1-antitrypsin) in urine remain one of the most promising peptide
Natalia Starodubtseva, Natalia Nizyaeva, Oleg Baev, Anna Bugrova, Masara Gapaeva, Kamilla Muminova, Alexey Kononikhin, Vladimir Frankevich, Eugene Nikolaev, Gennady Sukhikh   +9 more
openaire   +2 more sources

Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo. [PDF]

, 2018
Engineering of the Cpf1 crRNA has the potential to enhance its gene editing efficiency and non-viral delivery to cells. Here, we demonstrate that extending the length of its crRNA at the 5 end can enhance the gene editing efficiency of Cpf1 both in cells
Chong, Anthony, Chu, Hunghao, Fellmann, Christof, Jiang, Fuguo, Lee, Kunwoo, Liu, Hui, Mackley, Vanessa, Murthy, Niren, Park, Hyo, Rao, Anirudh, Wu, Joann   +10 more
core   +2 more sources

Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease. [PDF]

, 2017
Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced ...
Baye, Fitsum, Goswami, Chirayu Pankaj, Gurung, Ganga, Jackson, Isabel L., Katz, Barry P., Pavlovic, Radmila, Vujaskovic, Zeljko, Winans, Don, Zodda, Andrew   +8 more
core   +4 more sources

Hepatocyte-like cells reveal novel role of SERPINA1 in transthyretin amyloidosis [PDF]

Journal of Cell Science, 2018
ABSTRACT Transthyretin (TTR)-related familial amyloid polyneuropathy (ATTR) results from aggregation and extracellular disposition of misfolded TTR mutants. Growing evidence suggests the importance of hepatic chaperones for the modulation of pathogenesis.
Christoph Niemietz, Lutz Fleischhauer, Vanessa Sandfort, Sarah Guttmann, Andree Zibert, Hartmut H.-J. Schmidt   +5 more
openaire   +2 more sources

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

, 2018
Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M, Biasiolo, A, Cappon, A, Cavicchioli, L, Codolo, G, Doria, A., Gatto, M, Ghirardello, A, Luisetto, R, Maggioni, G, Pontisso, P, Saccon, F, Venturini, R   +12 more
core   +2 more sources

Splicing variants of SERPINA1 gene in ovine milk: characterization of cDNA and identification of polymorphisms. [PDF]

PLoS ONE, 2013
The serine protease inhibitor, clade A, member 1 (SERPINA1) is the gene for a protein called alpha-1-antitrypsin (AAT), which is a member of the serine protease inhibitor (serpin) superfamily of proteins. By conformational change, serpins control several
Cinzia Marchitelli, Alessandra Crisà, Elisa Mostarda, Francesco Napolitano, Bianca Moioli   +4 more
doaj   +1 more source