Results 71 to 80 of about 10,821 (196)
Genetics and Molecular Biology, 2008 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1) deficiency is one of the main genetic causes related to liver disease in children. In SERPINA1 deficiency the most frequent SERPINA1 alleles found are the PI*S
Guilherme Baldo +11 more
doaj +1 more source
Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. [PDF]
, 2016 Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants.To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated with the risk of COPD and severity of
Andrew J Wardlaw +71 more
core +12 more sources
Alimentary Pharmacology &Therapeutics, EarlyView.Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Lorenz Balcar +18 more
wiley +1 more source
CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans [PDF]
, 2019 Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy.
Buland, Justin R +14 more
core +3 more sources
The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source
International Journal of COPD, 2020 Gloria Pérez-Rubio,1 Enrique Ambrocio-Ortiz,1 Luis A López-Flores,1 Ana I Juárez-Martín,2 Luis Octavio Jiménez-Valverde,1 Susana Zoreque-Cabrera,1 Gustavo Galicia-Negrete,1 María Elena Ramírez-Díaz ...
Pérez-Rubio G +13 more
doaj
Respiratory Research, 2018 Background The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants.
Anna Beckmeyer-Borowko +22 more
doaj +1 more source
Respiratory Medicine Case Reports, 2021 Alpha 1 Antitrypsin Deficiency (AATD) is a rare condition primarily associated with lung complications and liver disease. As disease symptoms are similar to those in other respiratory conditions, patients generally experience long delays before receiving
Friedrich Kueppers
doaj +1 more source
Biomarkers for diagnosis of pre-eclampsia and endometriosis [PDF]
, 2018 Gynecological disorders are leading public health problems in developing countries with substantial impact on women's quality of life. Significant proportion of maternal mortality and reproductive morbidity is attributed to misdiagnosis ...
Ali, Amjad +6 more
core +1 more source
Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding
Oral Diseases, EarlyView.ABSTRACT Objective This observational, cross‐sectional, and analytical study aimed to explore the pathophysiological mechanisms of gingivitis in pregnancy by analyzing the salivary proteomic profile according to gingival bleeding status. Materials and Methods Pregnant women at the 27th week of gestation or beyond were categorized into two groups: those
Gerson Aparecido Foratori‐Junior +9 more
wiley +1 more source