Results 81 to 90 of about 10,821 (196)

Innate immune response is differentially dysregulated between bipolar disease and schizophrenia [PDF]

, 2015
Articles in PressSchizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions with a neurodevelopmental component. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. Also, image studies
Barreta, Luiz André Nardin, Baumont, Angelica de, Belmonte-de-Abreu, Paulo, Brentani, Helena, Carraro, Dirce Maria, Filho, Carlos Alberto Moreira, Fiorini, Alex, Lima, Leandro, Maschietto, Mariana, Olivieri, Eloisa Helena, Palha, Joana Almeida   +10 more
core   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexedmicroarray biomarker validation [PDF]

, 2017
We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals.
Acera, Arantxa, Bier, Frank F., Bistolas, Nikitas, Durán, Juan A., González, Nerea, Merayo Lloves, Jesús, Peter, Harald, Rodríguez, Sandra, Schumacher, Sören, Soria, Javier, Stöcklein, Walter, Suárez, Tatiana   +11 more
core   +3 more sources

Hyaluronic Acid Decoration Facilitates CD44‐Mediated Targeting and Alters Protein Corona Formation of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Cell recognition and uptake of extracellular vesicles (EVs) is mediated by a variety of surface molecules. Growing interest has recently been drawn towards glycan structures on EVs. Hyaluronic acid (HA) is a negatively charged glycosaminoglycan that can decorate the surface of EVs from different origins.
Heikki Kyykallio, Elena Scurti, Martina Hanzlíková, Kirsti Härkönen, Tuovi Salo, Veera Keinonen, Janne Capra, Tapani Viitala, Jaakko Teppo, Tatu Lajunen, Kirsi Rilla   +10 more
wiley   +1 more source

Influence of SERPINA1 Gene Polymorphisms on Anemia and Chronic Obstructive Pulmonary Disease

Journal of the Renin-Angiotensin-Aldosterone System, 2022
Background. Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear. Aim.
Thangavelu Sangeetha, Tajuddin Nargis Begum, Balasubramanian Balamuralikrishnan, Meyyazhagan Arun, Kannan R. R. Rengasamy, Natchiappan Senthilkumar, Shanmugam Velayuthaprabhu, Muthukrishnan Saradhadevi, Palanisamy Sampathkumar, Arumugam Vijaya Anand   +9 more
openaire   +2 more sources

Diagnosing Alpha-1-Antitrypsin Deficiency Using A PCR/Luminescence-Based Technology

International Journal of COPD, 2019
Martina Veith,1 Andreas Klemmer,1 Iker Anton,2 Rachid El Hamss,2 Noelia Rapun,2 Sabina Janciauskiene,3 Viktor Kotke,1 Christian Herr,4 Robert Bals,4 Claus Franz Vogelmeier,1 Timm Greulich1 1Department of Medicine, Pulmonary and Critical Care Medicine ...
Veith M, Klemmer A, Anton I, El Hamss R, Rapun N, Janciauskiene S, Kotke V, Herr C, Bals R, Vogelmeier CF, Greulich T   +10 more
doaj  

GENE SERPINA1: POTENCIAL MARCADOR DIAGNÓSTICO EM CARCINOMAS PAPILÍFEROS DA TIREOIDE

Revista UniVap, 2021
As neoplasias tireoidianas são o principal tipo de malignidade endócrina, sendo atualmente consideradas um problema de saúde pública com aumento constante em sua incidência nos últimos anos. A descoberta de marcadores moleculares que possam ser aplicados
Joyce Nascimento Santos, João Paulo da Silva Queiroz, Lázaro Pinto Medeiros Neto, André Bandiera de Oliveira Santos, Renata de Azevedo Canevari   +4 more
doaj   +1 more source

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior [PDF]

, 2016
Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur in the absence of a protease; when
Faull, Sarah V., Haq, Imran, Heyer Chauhan, Narinder, Irving, James A., Jagger, Alistair M., Kay, Christopher W. M., Liedtke, Maximilian, Lomas, David A., MIRANDA BANOS, MARIA ELENA, Motamedi Shad, Neda, Nanda, Arjun Scott, Ordóñez, Adriana, Perez, Juan, Salvadori, Enrico, Wort, Joshua L.   +14 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, Volume 20, Issue 3, Page 668-687, March 2026.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Haplotype-Aware Detection of SERPINA1 Variants by Nanopore Sequencing

The Journal of Molecular Diagnostics
α-1 Antitrypsin (AAT) is an acute-phase reactant with immunomodulatory properties that mainly inhibits neutrophil elastase. Low serum levels cause AAT deficiency (AATD), an underdiagnosed condition that predisposes to pulmonary and hepatic diseases. The SERPINA1 gene, which encodes AAT, contains >500 variants.
Mario A. González-Carracedo, Esther Herrera-Luis, María Marco-Simancas, Ainhoa Escuela-Escobar, Elena Martín-González, Olaia Sardón-Prado, Paula Corcuera, Jose M. Hernández-Pérez, Fabián Lorenzo-Díaz, José A. Pérez-Pérez   +9 more
openaire   +3 more sources