Results 91 to 100 of about 20,613 (283)

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Vaspin inhibits kallikrein 7 by serpin mechanism [PDF]

, 2013
The molecular target of the adipokine vaspin (visceral adipose tissue-derived serpin; serpinA12) and its mode of action are unknown. Here, we provide the vaspin crystal structure and identify human kallikrein 7 (hK7) as a first protease target of vaspin ...
Annette G. Beck-Sickinger, E. Bartholomeus Kuettner, John T. Heiker, Matthias Blüher, Matthias Kern, Michael Stumvoll, Nora Klöting, Norbert Sträter, Peter Kovacs, Stephan Schultz   +9 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Gross Intrahepatic Mass Formation Predicts the Primary Site of Perihilar Cholangiocarcinoma Based on Molecular Pathologic Studies

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Intrahepatic cholangiocarcinoma (iCCA) and extrahepatic cholangiocarcinoma (eCCA) are clinically and genetically distinct. However, the classification of perihilar cholangiocarcinoma (phCCA) with an intrahepatic tumor mass remains unclear.
Yuki Masuda, Naoto Kubota, Ryo Takemura, Yasuhito Arai, Yuta Abe, Osamu Itano, Minoru Esaki, Tatsuhiro Shibata, Yuko Kitagawa, Hidenori Ojima   +9 more
wiley   +1 more source

Binding of Extracellular Maspin to 1 Integrins Inhibits Vascular Smooth Muscle Cell Migration [PDF]

, 2009
Maspin is a serpin that has multiple effects on cell behavior, including inhibition of migration. How maspin mediates these diverse effects remains unclear, as it is devoid of protease inhibitory activity.
Akiyama, Al-Ayyoubi, Askari, Bailey, Bass, Bass, Bass, Becerra, Biliran, Blacque, Brown, Cella, Coe, Dollery, Filleur, Filleur, Galis, Gao, Humphries, Huntington, Häyry, Jiang, Khalkhali-Ellis, Laura Wagstaff, Law, Li, Li, Lorna Ravenhill, Luo, McGowen, Mould, Mould, Newby, Ngamkitidechakul, Odero-Marah, Owens, Pemberton, Pemberton, Rosemary Bass, Ross, Schreiner, Schwartz, Sechler, Seftor, Sheng, Sheng, Sheng, Shi, Shi, Smith, Stephens, Vincent Ellis, Yin, Zhang, Zou   +54 more
core   +2 more sources

Tap73 is essential for germ cell adhesion and maturation in testis [PDF]

, 2014
A core evolutionary function of the p53 family is to protect the genomic integrity of gametes. However, the role of p73 in the male germ line is unknown.
Dobbelstein, M., Holembowski, L., Kramer, D., Moll, U. M., Nemajerova, A., Riedel, D., Sordella, R.   +6 more
core   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities*

Journal of Biological Chemistry, 2015
Serpins regulate coagulation and inflammation, binding serine proteases in suicide-inhibitory complexes. Target proteases cleave the serpin reactive center loop scissile P1–P1′ bond, resulting in serpin-protease suicide-inhibitory complexes.
Sriram Ambadapadi, Ganesh Munuswamy-Ramanujam, Donghang Zheng, Colin E. Sullivan, E. Dai, Sufi Morshed, Baron McFadden, Emily R. Feldman, M. Pinard, R. McKenna, S. Tibbetts, A. Lucas   +11 more
semanticscholar   +1 more source

Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]

, 2015
SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo, Biasiolo, A, Cambieri, I, Cannito, Stefania, Cillo, U, Cillo, U, Colombatto, Sebastiano, David, E, Fasolato, S, Morello, E, Musso, Tiziana, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Pontisso, P, Quarta, S, Rovida, E, Smedile, Antonina, Turato, C, Tusa, I, Villano, G   +20 more
core   +3 more sources

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source