Inhibition of HCV by the serpin antithrombin III [PDF]
, 2012 Background: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with unfavorable IL28B genotypes ...
Asmal, Mohammed +5 more
core +2 more sources
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Helicobacter pylori-induced fibroblast-derived Serpin E1 promotes gastric cancer growth and peritoneal dissemination through p38 MAPK/VEGFA-mediated angiogenesis [PDF]
, 2023 Wei Cheng +7 more
openalex +1 more source
New data on the lithostratigraphy of Beiras Group (Schist Greywacke Complex) in the region of Góis-Arganil-Pampilhosa da Serra (Central Portugal) [PDF]
, 2013 [Abstract] In the course of geological surveys conducted in the region of Góis (Central Portugal) a new unit was recognized at the top of Boque-Serpins Formation, characterized by the presence of levels of quartzites interlayered with shales, now called ...
Meireles, C.
core +1 more source
Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans [PDF]
, 2010 Objective: To study the association of vaspin with glucose metabolism. Design: Cross-sectional and intervention study. Subjects and methods: The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108
Arafat, Ayman, M. +8 more
core +1 more source
Hepatology Research, EarlyView.Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura +11 more
wiley +1 more source
Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis) [PDF]
, 2016 Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a conformational proteinopathy characterised by neuronal inclusion bodies composed of the serine protease inhibitor (SERPIN), neuroserpin.
Crowther, DC, Lomas, DA, Roussel, BD
core
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich +2 more
core +1 more source
Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez +6 more
wiley +1 more source
Reproductive Biology and Endocrinology, 2011 Background SERPINs (serine protease inhibitors) regulate proteases involving fibrinolysis, coagulation, inflammation, cell mobility, cellular differentiation and apoptosis.
Takahashi Toru +3 more
doaj +1 more source