Results 111 to 120 of about 20,002 (295)

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, EarlyView.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source

New data on the lithostratigraphy of Beiras Group (Schist Greywacke Complex) in the region of Góis-Arganil-Pampilhosa da Serra (Central Portugal) [PDF]

, 2013
[Abstract] In the course of geological surveys conducted in the region of Góis (Central Portugal) a new unit was recognized at the top of Boque-Serpins Formation, characterized by the presence of levels of quartzites interlayered with shales, now called ...
Meireles, C.
core   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Inhibition of HCV by the serpin antithrombin III [PDF]

, 2012
Background: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with unfavorable IL28B genotypes ...
Asmal, Mohammed, Chung, Raymond Taeyong, Geiben-Lynn, Ralf, Letvin, Norman L, Lin, Wenyu, Seaman, Michael S.   +5 more
core   +2 more sources

Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors have shown beneficial effects in liver disease; however, the underlying mechanism of action and the effect across ...
Una Rastovic, Sara Campinoti, Lai Wei, Bruna Almeida, Sergio Francesco Bozzano, Ramin Amiri, Nicola Harris, Omolola Ajayi, Tsin Shue Koay, Caoimhe Kerins, Fiona N. Kenny, Ane Zamalloa, Lissette Adofina, Rosa Miquel, Yoh Zen, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Camilla Luni, Eileen Gentleman, Tanya Shaw, Daren Ure, Shilpa Chokshi, Luca Urbani, Elena Palma   +24 more
wiley   +1 more source

Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3‐Cytoskeleton‐Nucleoskeleton Axis in Mechanical Osteogenic Programming

Cell Proliferation, EarlyView.
Large segmental bone defects can result in non‐union of fractures and present a formidable challenge in clinical management. This study aims to investigate the role of mechanical stimulation in regulating osteogenic differentiation of stem cells via the mechanosensitive protein PDLIM5, thereby promoting bone regeneration and repair.
Yuchao Yang, Shutong Wu, Yining Wang, Jiajun Tang, Jiaxuan Liu, Jinyang Wang, Yunfeng Li, Asmat Ullah Khan, Muhammad Akram Khan, Wenqing Liu, Jinhui Zhu, Konghe Hu, Jingxing Dai, Jun Ouyang   +13 more
wiley   +1 more source

Ancestry and evolution of a secretory pathway serpin

BMC Evolutionary Biology, 2008
Background The serpin (serine protease inhibitor) superfamily constitutes a class of functionally highly diverse proteins usually encompassing several dozens of paralogs in mammals. Though phylogenetic classification of vertebrate serpins into six groups
Ragg Hermann, Kumar Abhishek
doaj   +1 more source

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis) [PDF]

, 2016
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a conformational proteinopathy characterised by neuronal inclusion bodies composed of the serine protease inhibitor (SERPIN), neuroserpin.
Crowther, DC, Lomas, DA, Roussel, BD
core  

On the use of an appropriate TdT-mediated dUTP-biotin nick end labeling assay to identify apoptotic cells. [PDF]

, 2015
Apoptosis is an essential cellular mechanism involved in many processes such as embryogenesis, metamorphosis, and tissue homeostasis. DNA fragmentation is one of the key markers of this form of cell death.
Behar-Cohen, F., Jaadane, I., Lebon, C., Rodriguez, G.V., Torriglia, A., Zaoui, I.E.   +5 more
core   +1 more source

Novel Scabies Mite Serpins Inhibit the Three Pathways of the Human Complement System

PLoS ONE, 2011
Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
A. Mika, Simone L Reynolds, F. Mohlin, C. Willis, P. M. Swe, D. Pickering, Vanja Halilovic, L. Wijeyewickrema, R. Pike, A. Blom, D. Kemp, K. Fischer   +11 more
semanticscholar   +1 more source