Results 131 to 140 of about 20,002 (295)
Molecular Ecology, EarlyView.ABSTRACT Energetic resources within organisms fuel both parasite growth and immune responses against them, but it is unclear whether energy allocation is sufficient to explain changes in infection outcomes under the threat of multiple parasites. We manipulated diet in flour beetles (Tribolium confusum) infected with two natural parasites and used a ...
Nora K. E. Schulz +6 more
wiley +1 more source
Periodontology 2000, EarlyView.AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer +4 more
wiley +1 more source
Schistosome serine protease inhibitors: parasite defense or homeostasis?
Anais da Academia Brasileira de Ciências, 2011 Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic ...
Landys A. Lopez Quezada +1 more
doaj +1 more source
Biomedical Chromatography, Volume 39, Issue 9, September 2025.ABSTRACT Human brain tumors were commonly monitored in hospital/clinical laboratories by immunohistochemistry (IHC) technique, which provides major insights into their classification. However, this technique remains laborious and still shows pitfalls. Therefore, the current study was endeavored to reveal the assets of the application of high‐throughput
Kaouthar Louati +16 more
wiley +1 more source
Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications
MedComm – Oncology, Volume 4, Issue 3, September 2025.Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, Volume 12, Issue 8, Page 1595-1607, August 2025.ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone +19 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 4, Page 2827-2833, August 2025.Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.ABSTRACT Background Duchenne muscular dystrophy (DMD) is a fatal X‐linked recessive disease due to loss‐of‐function variants in the DYSTROPHIN gene. DMD‐related skeletal muscle wasting is typified by an aberrant immune response involving upregulation of the TGFβ family of cytokines, like TGFβ1 and BMP4.
Hanna Sothers +7 more
wiley +1 more source
Functional, pathogenic, and pharmacological roles of protein folding intermediates
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1299-1307, August 2025.Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
wiley +1 more source
Extracellular proteases and their inhibitors ingenetic diseases of the central nervous system [PDF]
, 2017 Cumulative evidence has shown that a delicate balance between serine proteases and their inhibitors is crucial for normal functioning of several biological pathways.
Colleaux, Laurence +4 more
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