Results 51 to 60 of about 14,423 (252)
Structural aspects of serpin inhibition [PDF]
FEBS Letters, 1994 The essential roles of proteins of the serpin family in many physiological processes, along with new discoveries of their unique folding properties, have attracted intense interest in recent years. Many serpins display unusual mobile behavior attributed to rearrangements of α‐helical or β‐sheet domains, whereby large scale transitions accompany a ...
Andreas Schulze +3 more
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DNA accelerates the protease inhibition of a bacterial serpin chloropin
Frontiers in Molecular Biosciences, 2023 Serine protease inhibitors (Serpins) are the most widely distributed protease inhibitors in nature and have been identified from all kingdoms of life.
Jiawei Xu +6 more
doaj +1 more source
Parasites & Vectors, 2015 Background Rhipicephalus (Boophilus) microplus evades the host’s haemostatic system through a complex protein array secreted into tick saliva. Serine protease inhibitors (serpins) conform an important component of saliva which are represented by a large ...
Manuel Rodriguez-Valle +3 more
doaj +1 more source
Misfolding linked mutations of SERPINA1 gene are uncommon in preeclampsia
Archives of Medicine and Health Sciences, 2019 Background: Alpha-1 antitrypsin (A1AT) is a protease inhibitor that plays an important role in regulating oxidative stress in preeclampsia (PE). Recent studies have shown that A1AT is misfolded in PE.
Chandrakala Nagarajappa +2 more
doaj +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Nature, 1994 Recent structures of members of the serine proteinase inhibitor families (serpins) continue to emphasize the flexibility of the reactive loop and suggest possible 'active' conformations.
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Serpins from wheat grain [PDF]
FEBS Letters, 1994 Wheat serpin genes have been identified by Southern blot hybridization with three distinct barley protein Z probes. Immunoblot analysis with a monoclonal antibody towards barley protein Z confirmed expression of related M r ~ 40 kDa proteins in wheat grain.
Jørn Hejgaard +3 more
openaire +3 more sources
Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.
Biochemical Journal, 2016 Serpins are a widely distributed family of high molecular mass protein proteinase inhibitors that can inhibit both serine and cysteine proteinases by a remarkable mechanism-based kinetic trapping of an acyl or thioacyl enzyme intermediate that involves ...
P. Gettins, S. Olson
semanticscholar +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source