Results 141 to 150 of about 72,366 (294)

Crossing subfamily borders: Mechanosensitive TREK‐1 and alkaline‐activated TASK‐4 form heterodimers with unique functional and pharmacological properties

British Journal of Pharmacology, EarlyView.
Background and Purpose The tandem of two‐pore‐domain potassium (K2P) channels TREK‐1 and TASK‐4 are expressed in the heart and pancreatic beta‐cells. As TREK‐1 and TASK‐4 belong to distinct subfamilies with different functional hallmarks, heteromerization of these two channels was highly unexpected.
Sven Schütte, Florian Schick, Emilia De Martino, Hannah Schmitz, Katharina E. S. Zander, Franziska Holz, Patrick Sauer, Luise Mildeberger, Moritz Linder, Axel Loewe, Aytug K. Kiper, Silke Kauferstein, Martin K.‐H. Schäfer, Susanne Rinné, Niels Decher   +14 more
wiley   +1 more source

Fluorescent non-canonical amino acid provides insight into the human serotonin transporter

Nature Communications
The serotonin transporter (SERT), responsible for the reuptake of released serotonin, serves as a major target for antidepressants and psychostimulants. Nevertheless, refining the mechanistic models for SERT remains challenging.
Andreas Nygaard, Linda G. Zachariassen, Kathrine S. Larsen, Anders S. Kristensen, Claus J. Loland   +4 more
doaj   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

A Josep Maria Sert

, 2005
Pla detall, contrapicat, de la placa al pintor Josep Maria Sert.
Direcció Tècnica d'Urbanisme, Universitat de Barcelona. Centre de Recerca Polis   +1 more
core  

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

Gen SERT y respuesta a ISRS – es clínicamente útil

El gen transportador de serotonina (SERT, 5-HTT, SLC6A4) puede influir en la respuesta a los SSRI y en los efectos secundarios, particularmente en hombres caucásicos de mayor edad.
Mercedes Guaia Memita Guaia
core   +1 more source

Sert, medio siglo de arquitectura, 1928-1979. Obra completa [PDF]

, 2005
Ressenya del llibre, Sert. Mig segle d'arquitectura. Obra completa. Barcelona: Actar, 2005Reseña del libro, Sert. Mig segle d'arquitectura. Obra completa.
García Estévez, Carolina Beatriz
core  

Teriparatide Topical Delivery Supports Osseointegration in Ovariectomized Rats Receiving Cafeteria Diet and Bisphosphonate: An In Vivo Experimental Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Background Postmenopausal osteoporosis associated with cafeteria diet and bisphosphonate therapy may impair peri‐implant bone repair. Therefore, strategies to enhance osseointegration are needed. Aim This study investigated whether teriparatide‐coated implant surfaces enhance osseointegration in a rodent model of estrogen deficiency (OVX) and ...
Ana Cláudia Ervolino da Silva, Fábio Roberto de Souza Batista, Jaqueline Suemi Hassumi, Naara Gabriela Monteiro, Marina Santos Fernandes, Luana Marotta Reis Vasconcellos, Gabriel Mulinari‐Santos, Reinhard Gruber, Paulo Noronha Lisboa‐Filho, Roberta Okamoto   +9 more
wiley   +1 more source

A quoi sert le juriste … dans des négociations internationales en matière d’environnement? - Law and lawyers at multilateral environmental negotiations

, 2018
In our contribution we’ve transposd the question of the Conference “A quoi sert le droit d’environnement” into the question “A quoi sert le juriste?” and we’ve applied it on multilateral environmental ...
Van Eeckhoutte, Dries, À QUOI SERT LE DROIT DE L’ENVIRONNEMENT ? RÉALITÉ ET SPÉCIFICITÉ DE SON APPORT AU DROIT ET À LA SOCIÉTÉ Colloque en l’honneur du   +1 more
core  

GNSS navigation interference disrupts telemetry tracking of raptors migrating between Europe and Africa

Ibis, EarlyView.
Global Navigation Satellite System (GNSS) interference in war conflict zones can disrupt wildlife tracking for research and conservation efforts. In 2023 and 2024, we tagged Black Kites Milvis migrans in Moldova and Kazakhstan, respectively, with telemetry loggers, tracked them until September 2025 and found that 20 out of the 24 Black Kites had ...
Ivan Literák, Jan Škrábal, Ondřej Homola, Vitalie Ajder, Igor V. Karyakin   +4 more
wiley   +1 more source