Results 171 to 180 of about 72,366 (294)

Cross-Species Triage of SERT-Oriented Polyheteroaryl Candidates Prioritizes AD20/UtIA-0108 as an Early Neuroactive Candidate. [PDF]

Curr Issues Mol Biol
Komelkova MV, Fedorov SA, Isaeva VA, Utepova IA, Grygoreva YD, Bahareva IY, Moskaliuk VS, Kondaurova EM, Zhdanov AV, Platkovskii PO, Trestsova MA, Andreeva DA, Perfilev MA, Kochetkov AN, Vassiliev PM, Naumenko VS, Sarapultsev AP.   +16 more
europepmc   +1 more source

Restoration of neuromuscular function by mitochondrial transplantation in injured mouse skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Mice received chemical injury (cardiotoxin) in the tibialis anterior muscle of one limb, and the contralateral muscle was injected with phosphate‐buffered saline (PBS) as a sham control. Mice then received PBS or mitochondria suspended in PBS into the tail vein.
Stephen E. Alway, Peter J. Ferrandi, Hector G. Paez, Christopher R. Pitzer, Junaith S. Mohamed, Michael R. Deschenes, James A. Carson   +6 more
wiley   +1 more source

Characterization of Fish Serotonin, Dopamine and Norepinephrine Transporters as a Potential Target for Environmental Pharmaceuticals. [PDF]

Environ Sci Technol
Honda K, Han M, Mori F, Morinaga A, Nishimura Y, Kaneko R, Oizumi K, Kajiyama H, Ihara MO, Zhang H, Kato D, Toyota K, Lange A, Tyler CR, Iguchi T, Mushirobira Y, Nagae M, Soyano K, Ihara M, Miyagawa S.   +19 more
europepmc   +1 more source

Caloric restriction and aerobic exercise differentially counteract muscle–tendon dysfunction following diet‐induced obesity in C57BL/6J mice

The Journal of Physiology, EarlyView.
Abstract figure legend Diet‐induced obesity induced fibro‐adipogenic remodelling of the muscle–tendon unit, characterized by increased fibrosis, reduced specific force, impaired relaxation kinetics, elevated hysteresis, and reduced aerobic capacity and glucose tolerance.
Leonardo Cesanelli, Petras Minderis, Andrej Fokin, Aivaras Ratkevicius, Ingrida Balnyte, Polzonetti Valeria, Tomas Venckunas, Cameron Hill, Danguole Satkunskiene, Hans Degens   +9 more
wiley   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, Volume 183, Issue 23, Page 6824-6846, December 2026.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Centanafadine (Simtriyo®): a first-in-class triple reuptake inhibitor approved for attention-deficit/hyperactivity disorder (ADHD). [PDF]

Med Chem Res
Hu L.
europepmc   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 23, Page 6767-6786, December 2026.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

α-Synuclein regulates monoamine transporter capacity and amphetamine-induced efflux via modulation of transporter expression. [PDF]

J Pharmacol Exp Ther
Ludwig I, Moser S, Lukenic M, Connor M, Sofic A, Kaltenbrunner S, Pätzold C, Hausleitner A, Gilbert C, Sucic S, Roblek M, Steinkellner T.   +11 more
europepmc   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, Volume 183, Issue 23, Page 6787-6800, December 2026.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Serotonin as a Regulator of Innate and Adaptive Immunity: Mechanisms and Clinical Relevance in Inflammatory Disease. [PDF]

Cells
Inozemtsev V, Shashkovskaya V, Sergunova V.   +2 more
europepmc   +1 more source