Results 181 to 190 of about 72,366 (294)

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

British Journal of Pharmacology, Volume 183, Issue 23, Page 6737-6748, December 2026.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation

Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.
Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

Optogenetic Regulation of Localization and Function of Serotonin Transporter by Modulating Its Interaction with Soluble Guanylate Cyclase. [PDF]

Int J Mol Sci
Tan D, Ye H, Chen Y, Huang X, Cai X, Tian Y, Zhang YW.   +6 more
europepmc   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, Volume 100, Issue 5, Page 948-961, November 2026.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Neuropharmacology of levamisole and its phase I metabolites: lack of evidence for levamisole-cocaine interactions. [PDF]

Psychopharmacology (Berl)
Zolkowska D, Lehner KR, Partilla JS, Blough BE, Baumann MH.   +4 more
europepmc   +1 more source

Improved Serotonin Measurement With Fast‐Scan Cyclic Voltammetry: Analysis of Electrode Fouling by Fluoxetine in Live Brain Tissue

Analysis &Sensing, Volume 6, Issue 6, November 2026.
Fluoxetine (Prozac) is a drug that is useful for treating depression and for studying serotonin system function in live brain tissue. Unfortunately, the use of fluoxetine tends to foul electrodes when using fast‐scan cyclic voltammetry. In this work, we evaluated an extended serotonin waveform as a useful approach for mitigating fouling by fluoxetine ...
Chase Stucky, Delaney Lounce, Kailash Shrestha, Jing Tian, Ethan Gomez, Heng Du, Kandace Fleming, Michael A. Johnson   +7 more
wiley   +1 more source

Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta-Analyses. [PDF]

Diabetes Obes Metab
Pak K.
europepmc   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1389-1401, November 2026.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

« A quoi ça sert »

, 1989
Lamaison Didier. « A quoi ça sert ». In: Bulletin de l'Association Guillaume Budé, n°2, juin 1989. pp. 133-138.
openaire   +1 more source

Intestinal Epithelial-Protective Effects of <i>Leuconostoc mesenteroides</i> H40 in LPS-Stimulated HT-29 Cells. [PDF]

J Microbiol Biotechnol
Cha YJ, Jang HJ, Lee GW, Lee NK, Paik HD.   +4 more
europepmc   +1 more source