Results 1 to 10 of about 61,716 (249)

RU 486 blocks inhibitory effect of neonatal corticosterone administration on sertoli cell proliferation in mice [PDF]

Scientific Reports
Cortisol/corticosterone (CORT) are typical glucocorticoids and exert an anti-stress function. p27, a cyclin-dependent kinase inhibitor, acts as a terminal factor for Sertoli cell proliferation at the prepubescent stage. Our previous study showed neonatal
Hidenobu Miyaso, Yutaro Natsuyama, Shinichi Kawata, Tomiko Yakura, Zhong-Lian Li, Miyuki Kuramasu, Shota Tanifuji, Xi Wu, Yuki Ogawa, Yoshiharu Matsuno, Masahiro Itoh   +10 more
doaj   +2 more sources

miR-202-3p Regulates Sertoli Cell Proliferation, Synthesis Function, and Apoptosis by Targeting LRP6 and Cyclin D1 of Wnt/β-Catenin Signaling

Molecular Therapy - Nucleic Acids, 2019
MicroRNAs (miRNAs) play important roles in mammalian spermatogenesis, which is highly dependent on Sertoli cells. However, the functions and mechanisms of miRNAs in regulating human Sertoli cells remain largely unknown.
Chao Yang, Chencheng Yao, Ruhui Tian
exaly   +3 more sources

PTBP1 supports mouse spermatogenesis by facilitating cytoskeletal organization through the mTORC2–PKCα pathway in Sertoli cells [PDF]

Communications Biology
Somatic Sertoli cells in the seminiferous tubule provide structural and paracrine support for spermatogenesis. Proper regulation of Sertoli cell cytoskeleton dynamics is essential for this function; however, the regulatory mechanisms remain unclear. Here,
Manabu Ozawa, Jumpei Taguchi, Hideto Mori, Mio Kikuchi, Masafumi Muratani, Takuya Yamamoto, Yasuhiro Yamada, Nobuaki Yoshida, Masahito Ikawa   +8 more
doaj   +2 more sources

Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation

Frontiers in Endocrinology, 2019
Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited number of germ cells, the final number of Sertoli cells reached ...
Meroni Sb, Agostina Gorga, Maria Fernanda Riera   +2 more
exaly   +3 more sources

Unique Sertoli cell adaptations support enhanced spermatogenesis in chickens [PDF]

Journal of Animal Science and Biotechnology
Background The cellular basis of testicular development and spermatogenesis for the extreme sperm density in chickens (100-fold higher than mammals) remains poorly defined.
Gaoqing Xu, Zhuoxuan Gu, Ziming Wang, Jing Zhao, He Ding, Hongyu Liu, Yi Fang, Xin Ma, Jing Guo, Wenfa Lyu, Jun Wang   +10 more
doaj   +2 more sources

Updates in Sertoli Cell-Mediated Signaling During Spermatogenesis and Advances in Restoring Sertoli Cell Function

Frontiers in Endocrinology, 2022
Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to Sertoli cell number and function.
Victor A. Ruthig, Victor A. Ruthig, Dolores J. Lamb, Dolores J. Lamb   +3 more
doaj   +1 more source

Expression of NKX 3.1 in Sertoli Cell Tumors

Pakistan Armed Forces Medical Journal, 2022
Objective: To evaluate the NKX3.1 expression by immunohistochemistry in normal testicular parenchyma and in Sertoli cell tumours and Sertoli Leydig cell tumours of the testes and ovary. Study Design: Retrospective longitudinal study.
Arooj Fatima, Sajid Mushtaq, Asif Loya
doaj   +1 more source

Long-term effects of early postnatal stress on Sertoli cells

Frontiers in Genetics, 2022
Sertoli cells are somatic cells in testis essential for spermatogenesis, that support the development, maturation, and differentiation of germ cells.
Kristina M. Thumfart, Samuel Lazzeri, Samuel Lazzeri, Samuel Lazzeri, Francesca Manuella, Isabelle M. Mansuy   +5 more
doaj   +1 more source

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]

, 2009
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H., Baker, P.J., Huhtaniemi, I., Morris, I.D., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis [PDF]

, 2008
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Claessens, Frank, De Gendt, Karel, Denolet, Evi, Saunders, Philippa T K, Sharpe, Richard, Swinnen, Johannes V, Verhoeven, Guido, Willems, Ariane   +7 more
core   +1 more source