Frontiers in Endocrinology, 2022 Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to Sertoli cell number and function.
VÍCTOR A Ruthig, Dolores J Lamb
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Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis [PDF]
Endocrine Reviews, 2004 Spermatogenesis is the process by which a single spermatogonium develops into 256 spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the epithelial cycle were first described, reproductive biologists have been in pursuit of one question: How can a spermatogonium traverse the epithelium, while at the same time ...
Dolores D Mruk +2 more
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The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation
Frontiers in Endocrinology, 2021 Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways.
Wasim Shāh, Ranjha Khan, Jie Wen
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Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation
Frontiers in Endocrinology, 2019 Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited number of germ cells, the final number of Sertoli cells reached ...
Silvina BEATRIZ Meroni +2 more
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PTBP1 supports mouse spermatogenesis by facilitating cytoskeletal organization through the mTORC2–PKCα pathway in Sertoli cells [PDF]
Communications BiologySomatic Sertoli cells in the seminiferous tubule provide structural and paracrine support for spermatogenesis. Proper regulation of Sertoli cell cytoskeleton dynamics is essential for this function; however, the regulatory mechanisms remain unclear. Here,
Manabu Ozawa +8 more
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Expression of NKX 3.1 in Sertoli Cell Tumors
Pakistan Armed Forces Medical Journal, 2022 Objective: To evaluate the NKX3.1 expression by immunohistochemistry in normal testicular parenchyma and in Sertoli cell tumours and Sertoli Leydig cell tumours of the testes and ovary. Study Design: Retrospective longitudinal study.
Arooj Fatima, Sajid Mushtaq, Asif Loya
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Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli–Sertoli and Sertoli–germ cell interface [PDF]
Experimental Cell Research, 2007 The coxsackie and adenovirus receptor (CAR), a putative cell-cell adhesion molecule, has attracted wide interest due to its importance in viral pathogenesis and in mediating adenoviral gene delivery. However, the distribution pattern and physiological function of CAR in the testis is still not clear.
Lee, WWM, Wang, CQF, Mruk, DD, Cheng, CY
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Long-term effects of early postnatal stress on Sertoli cells
Frontiers in Genetics, 2022 Sertoli cells are somatic cells in testis essential for spermatogenesis, that support the development, maturation, and differentiation of germ cells.
Kristina M. Thumfart +5 more
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Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction. [PDF]
PLoS ONE, 2010 Sertoli cells, the support cells of mammalian spermatogenesis, are regulated by a number of nuclear factors and express retinoblastoma (RB) tumor suppressor protein.
Roopa L Nalam +2 more
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Frontiers in Endocrinology, 2022 Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
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