Results 121 to 130 of about 52,947 (295)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Reasons for patient reluctance to take preventive medications for migraine: Results of the OVERCOME (US) study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This study was undertaken to evaluate patient reasons for nonadoption of migraine‐preventive medications. Despite clear recommendations and eligibility criteria for migraine‐preventive treatment by the American Headache Society and the availability of these treatments, many people with migraine are not taking appropriate ...
Jessica Ailani, Rose Okonkwo, Elizabeth Johnston, Helen Hochstetler, Betzaida Martinez, Anthony Zagar, Robert A. Nicholson, Bert B. Vargas, E. Jolanda Muenzel, Richard B. Lipton   +9 more
wiley   +1 more source

ACCOUNTING FOR MONOTONE ATTRITION IN A POSTPARTUM DEPRESSION CLINICAL TRIAL [PDF]

, 2006
Longitudinal studies in public health, medicine and the social sciences are often complicated by monotone attrition, where a participant drops out before the end of the study and all his/her subsequent measurements are missing.
Roumani, Yazan
core  

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Migraine and Restless Legs Syndrome: A Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT Restless legs syndrome is a sensorimotor disorder of sleep/wake regulation that frequently coexists with migraine, affecting patients' quality of life. This study aimed to estimate the prevalence of restless legs syndrome in individuals with migraine and to explore the associated clinical, demographic and behavioural aspects.
Florindo d'Onofrio, Maria Cropano, Giada Panzino, Mariachiara Gaita, Giulio Cicarelli, Piero Barbanti, Gerardo Casucci, Simona Raimo, Antonio Costanzo   +8 more
wiley   +1 more source

Antidepressants, sertraline and paroxetine, increase calcium influx and induce mitochondrial damage-mediated apoptosis of astrocytes

OncoTarget, 2017
The impacts of antidepressants on the pathogenesis of dementia remain unclear despite depression and dementia are closely related. Antidepressants have been reported may impair serotonin-regulated adaptive processes, increase neurological side-effects ...
C. Then, Kao-Hui Liu, Ming-Hsuan Liao, Kuo-Hsuan Chung, Jia-Yi Wang, S. Shen   +5 more
semanticscholar   +1 more source

Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT Agomelatine, a melatoninergic antidepressant, is often prescribed to improve sleep disturbance, though meta‐analytic evidence is currently lacking. This systematic review and meta‐analysis assessed its efficacy and tolerability in sleep outcomes compared to placebo.
Anastasios Stefanou, Ioannis Anastasiou, Panagiota Fallon, Eleni Glarou, Nikolaos Christodoulou, Andreas S. Lappas, Vasilios‐Panteleimon Bozikas, Myrto T. Samara   +7 more
wiley   +1 more source

Simultaneous Determination of Human Plasma Levels of Citalopram, Paroxetine, Sertraline, and Their Metabolites by Gas Chromatography—Mass Spectrometry [PDF]

, 2017
A gas chromatography—mass spectrometry method is presented which allows the simultaneous determination of the plasma concentrations of the selective serotonin reuptake inhibitors citalopram, paroxetine, sertraline, and their pharmacologically active N ...
Amey, M., Baumann, P., Bouchoux, G., Cochard, N., Eap, C.B., Savary, L.   +5 more
core  

Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption

Obesity Reviews, EarlyView.
ABSTRACT Obesity represents a significant threat to global public health, with an estimated 16% of adults worldwide (2022) being classified as people with obesity, with a body mass index of 30 or more. Bariatric surgery is regarded as the most effective treatment option for people with obesity, with the three main types of bariatric surgery being ...
Danielle Wigg, Andrea Edginton, Matthew D. Jones, Nikoletta Fotaki   +3 more
wiley   +1 more source

Detection of Ursid Gammaherpesvirus 2 in Asiatic Black Bears (Ursus thibetanus) With Keratoconjunctivitis

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objective To investigate the potential contribution of herpesvirus infection in the development of ocular surface disease in Asiatic black bears (Ursus thibetanus). Animals Studied Eight captive Asiatic black bears housed at a wildlife sanctuary were examined during routine health assessments.
Katharina Thieme, Marc Gölkel, J. Corinna Eule, Lesley Halter‐Gölkel, Dusan Kunec, Frank Göritz, Sina Feyer, Bich Ngoc Bui, Jakob Trimpert   +8 more
wiley   +1 more source