Results 131 to 140 of about 47,341 (232)

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

Efficacy of Dextromethorphan Augmentation in SSRI‐Resistant Obsessive–Compulsive Disorder: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology.
Ahmad Zolghadriha, Afagh Anjomshoaa, Romina Bagheri   +2 more
wiley   +1 more source

FIGO best practice recommendations for the mental health of women at menopausal age

International Journal of Gynecology &Obstetrics, Volume 173, Issue 2, Page 588-601, May 2026.
Abstract Mental health during the menopausal transition requires focused attention to ensure supportive experiences for women. This review presents the International Federation of Gynecology and Obstetrics (FIGO) recommendations and summarizes the evidence, addressing 13 key questions framed by members of the FIGO Committee on Women at Menopausal Age ...
Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea Genazzani, Diana Ramos, Elizabete Argale, Gandhali Deshpande, Martha Hicky, Agnaldo Lopes Da Silva Filho, Enrique Herrera, Milan Balkrishnan   +10 more
wiley   +1 more source

Decolonizing infant mental health: Black maternal mental health decision‐making

Infant Mental Health Journal: Infancy and Early Childhood, Volume 47, Issue 3, May 2026.
Abstract Over the last three decades (and maybe longer), studies have documented persistent race‐based maternal mental health disparities, whereas Black mothers are more likely to experience mental health concerns, and least likely to access formal mental health services due to structural racism and other social determinants.
Amittia Parker
wiley   +1 more source

Out‐of‐Pocket Costs and Antidepressant Adherence in Head and Neck Cancer Survivors

Psycho-Oncology, Volume 35, Issue 5, May 2026.
ABSTRACT Background Head and neck cancer (HNC) survivors have a high burden of depression, yet real‐world antidepressant adherence and the role of patient out‐of‐pocket (OOP) costs in this population remain poorly characterized. Methods We analyzed a retrospective cohort of US adults with HNC and a new antidepressant prescription in Merative MarketScan
Gennaro Di Tosto, Neil K. Mehta, Christopher W. Noel, Ann Scheck McAlearney, Lauren E. Miller   +4 more
wiley   +1 more source

The Effect of Sertraline on Hemodynamic Parameters and Nitric Oxide Production in Isolated Rat Hearts Subjected to Ischemia and Reperfusion

Journal of Experimental Pharmacology, 2019
Bartosz Grotthus, Adam Szeląg Department of Pharmacology, Wroclaw Medical University, Wroclaw, PolandCorrespondence: Bartosz GrotthusDepartment of Pharmacology, Wroclaw Medical University, Ul. Jana Mikulicza-Radeckiego 2, Wrocław 50-345, PolandTel +48 71
Grotthus B, Szeląg A
doaj  

Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 374-401, May 2026.
ABSTRACT Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro‐cognitive interventions show promise, trial findings are inconsistent, potentially due to baseline factors influencing treatment response.
Dimosthenis Tsapekos, Michail Kalfas, Johanna M. Schandorff, Caterina del Mar Bonnin, Christopher R. Bowie, Vicent Balanzá‐Martínez, Katherine E. Burdick, Andre F. Carvalho, Annemieke Dols, Katie Douglas, Peter Gallagher, Gregor Hasler, Lars V. Kessing, Hanne L. Kjærstad, Beny Lafer, Kathryn E. Lewandowski, Carlos López‐Jaramillo, Anabel Martinez‐Aran, Roger S. McIntyre, Richard J. Porter, Scot E. Purdon, Ayal Schaffer, Paul R. A. Stokes, Tomiki Sumiyoshi, Ivan J. Torres, Tamsyn E. Van Rheenen, Lakshmi N. Yatham, Jeff Zarp, Allan H. Young, Eduard Vieta, Kamilla W. Miskowiak   +30 more
wiley   +1 more source

Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Sertraline is commonly used to treat mental health conditions in youth. However, its tolerability and efficacy vary between individuals, partly due to interindividual differences in drug metabolism. This study assessed the individual and combined impact of genetic variation in cytochrome P450 drug‐metabolizing enzymes on patient‐reported side ...
Samuel Gerlach, Abdullah Al Maruf, Sarker M. Shaheen, Ryden McCloud, Madison Heintz, Laina McAusland, Paul D. Arnold, Chad A. Bousman   +7 more
wiley   +1 more source

The dual role of sertraline: From antidepressant to antifungal drug with broad metabolic disruption. [PDF]

Genet Mol Biol
Azevedo MIG, Santos-Saboya MJ, Neves-da-Rocha J, Petrucelli MF, Martinez-Rossi NM, Rossi A.   +5 more
europepmc   +1 more source