Results 121 to 130 of about 47,341 (232)

Real‐World Patient Characteristics and Treatment Patterns Among Patients With Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)

Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Objective Interstitial cystitis/bladder pain syndrome (IC/BPS) is linked to bladder and/or pelvic pain, pressure, and discomfort with urinary frequency. Despite guidelines, there is a need for better treatment options. This study analyzed patient demographics, clinical characteristics, and treatment patterns for medications and procedures in ...
Jaromir Mikl, Tiange Yu, Benjamin T. Carter, Andrew Rava, Xin Zhao, Catherine Allende, Amie Devlin, Valentine Pascale, Roger Dmochowski   +8 more
wiley   +1 more source

A Systematic Review and Narrative Synthesis Comparing the Efficacy of Dapoxetine and Clomipramine in the Management of Premature Ejaculation

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Dapoxetine (on‐demand SSRI) and clomipramine (daily TCA) are commonly used for premature ejaculation (PE), yet direct comparative evidence remains limited and heterogeneous, particularly because dapoxetine is administered on‐demand while clomipramine requires daily dosing. To systematically review evidence comparing dapoxetine and clomipramine
Khaled Moheyiddin, Ahmed H. Hassan
wiley   +1 more source

Differential effects of ketamine enantiomers on EEG parameters including the gamma‐delta shift phenomenon

British Journal of Pharmacology, Volume 183, Issue 12, Page 3340-3354, June 2026.
Background and Purpose Ketamine consists of two enantiomers, (R)‐ketamine and (S)‐ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)‐enantiomer has been approved for the treatment of major depressive disorder, whereas recent clinical studies have failed to demonstrate an antidepressant effect for (R)‐ketamine.
Szabolcs Koncz, Dóra Pothorszki, Noémi Papp, Donát Pál, György Bagdy   +4 more
wiley   +1 more source

Effects of Opioids, Benzodiazepines, Gabapentinoids, and Antidepressants on Fracture Risk in Alcohol‐Related Cirrhosis

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background Patients with alcohol‐related liver cirrhosis (ALD cirrhosis) have an increased risk of falls and fractures. Opioids, benzodiazepines, gabapentinoids, and antidepressants are known to increase fall risk. Aims We aimed to determine the effects of opioids, benzodiazepines, gabapentinoids, and antidepressants on fracture risk in ALD ...
Frederik Kraglund, Thomas Deleuran, Marie Aarup Storgaard, Eva Sædder, Peter Jepsen   +4 more
wiley   +1 more source

Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids

Translational Psychiatry
In addition to modulating serotonin transport, selective serotonin reuptake inhibitors (SSRIs) have multiple other mechanisms that may contribute to clinical effects, and some of these latter actions prompt repurposing of SSRIs for non-psychiatric ...
Yukitoshi Izumi, Angela M. Reiersen, Eric J. Lenze, Steven J. Mennerick, Charles F. Zorumski   +4 more
doaj   +1 more source

Palliative management of refractory dyspnea in COPD [PDF]

, 2006
Auckland, New ...
Currow, David Christopher, Abernethy, Amy Pickar, Uronis, H E   +2 more
core  

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1385-1396, May 2026.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Addressing Behavioral and Psychiatric Symptoms in Dystonia: A Case Report of Fahr Disease

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Abnormal calcium deposits in areas of the brain that control movement, including basal ganglia and cerebellum, are the hallmark of Fahr's syndrome. This report highlights the importance of clinicians being vigilant regarding behavioral and neuropsychiatric symptoms when evaluating cases of dystonia.
Tara Khoeini, Mohammad Javad Sinaeefar
wiley   +1 more source

Geriatric Depression Mimicking Parkinson's Disease: A Case of Levodopa‐Responsive Pseudoparkinsonism With a 3‐Year Follow‐Up

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Long‐term clinical course of a patient with geriatric depression presenting with levodopa‐responsive pseudoparkinsonism over a 3‐year follow‐up period. ABSTRACT Geriatric depression often presents with psychomotor retardation. Severe psychomotor retardation may manifest as pseudoparkinsonism, which mimics Parkinson's disease (PD) and is often difficult
Kenshiro Imaizumi, Junichi Goto, Kazuya Isoda, Tetsuya Watanabe, Yohei Nakamura, Suzuha Oyamada, Masashi Toda, Koki Hirazumi, Sachi Yamashiro, Yoshihiro Nabeshima   +9 more
wiley   +1 more source