Results 141 to 150 of about 52,947 (295)

Molecular Basis of the Leishmanicidal Activity of the Antidepressant Sertraline as a Drug Repurposing Candidate

open access: yesAntimicrobial Agents and Chemotherapy, 2018
Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin.
Marta L. Lima   +7 more
semanticscholar   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Psychotropic Use Among Classroom Teachers in Espírito Santo: A Cross‐Sectional Study

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 2, February 2026.
ABSTRACT Purpose To assess the prevalence of psychotropic use among classroom teachers and to identify associated factors. Methods A cross‐sectional study was conducted between January and February 2024 in Espírito Santo, Brazil. The study included teachers from 20 state schools selected through probabilistic sampling.
Yohan Cancilheri Mazzini   +5 more
wiley   +1 more source

Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature. [PDF]

open access: yes, 2019
Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and ...
Bonn-Miller, Marcel   +2 more
core  

Duplicate Prescription Patterns in Patients With Substance Use Disorders

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT This study sought to investigate the frequency and characteristics of duplicate prescriptions (DPs) in psychiatric inpatients with substance use disorders using a DP classification that differentiates between appropriate DPs (ADPs) and potentially inappropriate DPs (PIDPs). The study was conducted as a monocentric retrospective cross‐sectional
Johannes Heck   +8 more
wiley   +1 more source

Urinary Incontinence Associated with Sertraline use in a Young SSRI-Naïve Female Patient: a Case Report

open access: yesJurnal Psikiatri Surabaya
Introductions: Urinary incontinence is a side effect of several antidepressants, especially those in the SSRI and SNRI groups. Sertraline, a popular SSRI effective against a wide range of mental disorders, is one such drug with a clear association with a
Anna Elissa
doaj   +1 more source

Sertraline and Mirtazapine Versus Placebo in Subgroups of Depression in Dementia: Findings From the HTA-SADD Randomized Controlled Trial [PDF]

open access: hybrid, 2019
Marij Zuidersma   +4 more
openalex   +1 more source

A Tutorial on Optimal Dynamic Treatment Regimes

open access: yesStatistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT A dynamic treatment regime (DTR) is a sequence of treatment decision rules tailored to an individual's evolving status over time. In precision medicine, much focus has been placed on finding an optimal DTR which, if followed by everyone in the population, would yield the best outcome on average; and extensive investigations have been conducted
Chunyu Wang, Brian D. M. Tom
wiley   +1 more source

Interventions to Improve Outcomes After Pregnancy Loss: A Systematic Review

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 3, Page 365-374, February 2026.
ABSTRACT Background Stillbirth, second‐trimester miscarriage and recurrent miscarriage carry significant consequences for women. We lack sufficient high‐quality evidence of interventions to improve a woman's health and subsequent pregnancy outcomes after discharge to the community.
Becky MacGregor   +9 more
wiley   +1 more source

Exposure therapy and sertraline in social phobia: 1-year follow-up of a randomised controlled trial [PDF]

open access: bronze, 2003
Tone Tangen Haug   +6 more
openalex   +1 more source

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