Results 11 to 20 of about 52,947 (295)
Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth [PDF]
Molecular Cancer Therapeutics, 2020 Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival, and chemotherapy resistance. Although normal cells often rely on extracellular serine and glycine supply, a significant subset of cancers becomes addicted to intracellular ...
Shauni Lien Geeraerts +15 more
openalex +2 more sources
Efficacy of Prolonged Exposure Therapy, Sertraline Hydrochloride, and Their Combination Among Combat Veterans With Posttraumatic Stress Disorder [PDF]
JAMA psychiatry, 2018 Importance Meta-analyses of treatments for posttraumatic stress disorder (PTSD) suggest that trauma-focused psychotherapies produce greater benefits than antidepressant medications alone. Objective To determine the relative efficacy of prolonged exposure
Sheila A. M. Rauch +16 more
openalex +2 more sources
The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
Archives of Toxicology, 2020 Si Chen +9 more
openalex +3 more sources
Pharmaceutics, 2022 Being a biopharmaceutics classification system class II drug, the absorption of sertraline from the gut is mainly limited by its poor aqueous solubility.
Anroop B Nair +9 more
semanticscholar +1 more source
International Journal of Neuropsychopharmacology, 2022 Background Compared with adults with depression in the general population, elderly depressive patients are prone to poor treatment response, more side effects, and early withdrawal with current antidepressants (which principally modulate monoamines ...
Chieh-Hsin Lin, Shi-Heng Wang, H. Lane
semanticscholar +1 more source
Antidepressant Drug Sertraline against Human Cancer Cells
Biomolecules, 2022 The use of FDA-approved drugs for new indications represents a faster and more economical way to find novel therapeutic agents for cancer therapy, compared to the development of new drugs.
Diana Duarte, N. Vale
semanticscholar +1 more source
Clinical and Translational Science, 2022 Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants.
L. S. Bråten +4 more
semanticscholar +1 more source
Sertraline-Associated Riboflavin-Responsive Lipid Storage Myopathy: Report of Two Case. [PDF]
Muscle NerveSertraline exposure can lead to an acquired riboflavin‐responsive multiple acyl‐CoA dehydrogenase deficiency (MADD). In patients with this acquired form of MADD, riboflavin supplementation can even lead to full clinical recovery and marked serological recovery before discontinuation of sertraline.
Shaibani A, Taylor A.
europepmc +2 more sources
Sertraline concentrations in pregnant women are steady and the drug transfer to their infants is low
European Journal of Clinical Pharmacology, 2021 Sertraline, a selective serotonin reuptake inhibitor (SSRI), is one of the most commonly used antidepressant during pregnancy. Plasma sertraline concentrations vary markedly between individuals, partly explained by variability in hepatic drug ...
E. Heinonen +7 more
semanticscholar +1 more source
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm
Human Reproduction, 2021 STUDY QUESTION Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? SUMMARY ANSWER The SSRI antidepressant Sertraline (e.g.
R. Rahban +10 more
semanticscholar +1 more source