Results 51 to 60 of about 52,947 (295)

Assessment of a method to detect signals for updating systematic reviews. [PDF]

, 2014
BackgroundSystematic reviews are a cornerstone of evidence-based medicine but are useful only if up-to-date. Methods for detecting signals of when a systematic review needs updating have face validity, but no proposed method has had an assessment of ...
Johnsen, Breanne, Motala, Aneesa, Newberry, Sydne J, Shekelle, Paul G   +3 more
core   +1 more source

The role of harms and burdens in clinical practice guidelines: Lessons learned from the American Psychological Association's guideline development

Clinical Psychology: Science and Practice, EarlyView., 2020
Abstract Growing evidence supports the efficacy of various psychosocial interventions yet provides very little information about the potential harms and burdens of treatment. Lacking such information makes it difficult to make truly informed decisions about treatment options.
Raquel W. Halfond, Caroline Vaile Wright, Lynn F. Bufka   +2 more
wiley   +1 more source

The effect of zopiclone co-administration on sertraline initial dosage optimization in pediatric major depressive disorder patients based on model-informed precision dosing

Frontiers in Pharmacology
ObjectiveThe present study aims to explore the initial dosage optimization of sertraline in pediatric major depressive disorder (MDD) patients based on model-informed precision dosing (MIPD).MethodsA total of 111 pediatric MDD patients treated with ...
Xiao Chen, Ke Hu, Hao-Zhe Shi, Su-Mei He, Yang Yang, Chao-Wen Yang, Yue Zhang, Xue Tian, Ye Li, Yu-Hang Gao, Wen-Yi Xu, Cun Zhang, Dong-Dong Wang   +12 more
doaj   +1 more source

Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

Neurobiology of Disease, 2008
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder resulting from CAG repeat expansion in the gene that encodes for the protein huntingtin.
Wenzhen Duan, Qi Peng, Naoki Masuda, Eric Ford, Erik Tryggestad, Bruce Ladenheim, Ming Zhao, Jean Lud Cadet, John Wong, Christopher A. Ross   +9 more
doaj   +1 more source

Population pharmacokinetic approach to guide personalized sertraline treatment in Chinese patients

Heliyon
Object: Sertraline is a first-line SSRI for the treatment of depression and has the same effectiveness along with a superior safety profile compared to other medications.
Zi Zhang, Zhihao Guo, Yaqian Tan, Lu Li, Zhanzhang Wang, Yuguan Wen, Shanqing Huang, Dewei Shang   +7 more
doaj   +1 more source

Alcohol addiction: a molecular biology perspective. [PDF]

, 2015
Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people.
Ferraguti, Giampiero, Lucarelli, Marco, Pascale, Esterina   +2 more
core   +1 more source

Machine learning-based prediction of sertraline concentration in patients with depression through therapeutic drug monitoring

Frontiers in Pharmacology
Background: Sertraline is a commonly employed antidepressant in clinical practice. In order to control the plasma concentration of sertraline within the therapeutic window to achieve the best effect and avoid adverse reactions, a personalized model to ...
Ran Fu, Ran Fu, Xin Hao, Jing Yu, Jing Yu, Donghan Wang, Donghan Wang, Jinyuan Zhang, Ze Yu, Fei Gao, Chunhua Zhou, Chunhua Zhou   +11 more
doaj   +1 more source

Detecting serotonin system in rats with myocardial infarction and/or depression after selective serotonin reuptake inhibitor therapy

Heart and Mind, 2017
Objectives: The aim of this study is to explore the effects on serotonergic system of sertraline in the Sprague–Dawley (SD) rats of myocardial infarction (MI), depression, and depression post-MI.
Yanping Ren, Lijun Zhang, Wanlin Wei, Meiyan Liu   +3 more
doaj   +1 more source

Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial

BMC Pharmacology and Toxicology, 2022
Background Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually relieve the severity of symptoms by as much as 20–30%, and satisfactory treatment is obtained in 40–60% of patients with OCD.
Ala Ghobadian, Saba Mokhtari, Behnam Shariati, Leila Kamalzadeh, Mohsen Shati, Mehrdad Eftekhar Ardebili, Masoomeh Yarahmadi, Mohammadreza Shalbafan   +7 more
doaj   +1 more source

CYP2C19-Guided Escitalopram and Sertraline Dosing in Pediatric Patients: A Pharmacokinetic Modeling Study

Journal of child and adolescent psychopharmacology, 2019
Objective: Cytochrome P4502C19 (CYP2C19) is a highly polymorphic gene that encodes an enzyme that metabolizes escitalopram and sertraline, two selective serotonin reuptake inhibitors (SSRIs) that are FDA approved for pediatric use and commonly used to ...
J. Strawn, Ethan A Poweleit, L. Ramsey
semanticscholar   +1 more source