Results 181 to 190 of about 2,319,607 (308)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of highly abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens. [PDF]

Front Mol Biosci
Macur K, Bogucka AE, Fel-Tukalska A, Skokowski J, Ołdziej S, Czaplewska P.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

<i>Etlingera hemisphaerica</i> modulates mercury chloride-induced alterations in <i>Rattus norvegicus</i> serum proteins. [PDF]

Open Vet J
Ruyani A, Parlindungan D, Samitra D, Rozi ZF, Tualeka AR, Muhammad DRA, Susanti AD.   +6 more
europepmc   +1 more source

Serum proteins and electrophoretic profile in horses undergoing crotalid venom hyperimmunization. [PDF]

J Equine Sci, 2022
Ramos MGDSN, Campos SDE, Strauch MA, Ott LC, Macieira DB, de Alencar NX, Lessa DAB.   +6 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Changes in Serum Proteins in Cats with Obesity: A Proteomic Approach. [PDF]

Animals (Basel)
Cañadas-Vidal E, Muñoz-Prieto A, Rešetar Maslov D, Rubić I, González-Sánchez JC, Garcia-Martinez JD, Ceron JJ, Mrljak V, Pardo-Marin L, Martinez-Subiela S, Tvarijonaviciute A.   +10 more
europepmc   +1 more source

Analysis of Silicon Quantum Dots and Serum Proteins Interactions Using Asymmetrical Flow Field-Flow Fractionation. [PDF]

Langmuir, 2023
Nagarajan U, Chandra S, Yamazaki T, Shirahata N, Winnik FM.   +4 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Synergistic and individual actions of nanoemulsified vegetable oil and betaine as natural growth promoters on broiler performance, serum proteins, lipid profile, and safety enzymes. [PDF]

PLoS One
Al-Garadi MA, Suliman GM, Hussein EO, Al-Owaimer AN, Swelum AA, Almalamh NA, Alhotan RA, Qaid MM.   +7 more
europepmc   +1 more source