Results 61 to 70 of about 797,844 (252)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
THE KAZAKH LANGUAGE HAS THE ASPECT CATEGORY IN ITS MATRIX
RUDN Journal of Language Studies, Semiotics and Semantics, 2019 The subject of the article is the absence of an aspect category, expressing main ideas of sentence propositions in the morphology of the Kazakh language and the conceptual confusion of the aspect category with tense category in the Kazakh language, which
Fazira A. Kakzhanova
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Georg Cantor i idea jedności nauki
Zagadnienia Filozoficzne w Nauce, 2009 G. Cantor presented - in an unpublished paper (1884) - a vision of the unity of science. He argued all sciences can be reduced directly to the set theory. A source of this idea was for Cantor the unity of mathematics (on the basis of set theory).
Jerzy Dadaczyński
doaj
The Modal Status of Generative Principles
MetaphysicsThis contribution to a symposium marking the 30th anniversary of Kit Fine’s “Essence and Modality” raises a general question for essentialist theories of modality: What sort of proposition can figure in the essence of a property? Several versions of Fine’
Gideon Rosen
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Formal methods in software development: A road less travelled
South African Computer Journal, 2010 An integration of traditional verification techniques and formal specifications in software engineering is presented. Advocates of such techniques claim that mathematical formalisms allow them to produce quality, verifiably correct, or at least highly ...
John A van der Poll
doaj