Results 91 to 100 of about 1,431,450 (340)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
BuildingsInsufficient public service facilities in rural areas, which leads to failures in meeting the needs of villagers, has become a significant barrier to the high-quality development of rural regions.
Mengying Wang +6 more
doaj +1 more source
Role of targeted therapy in the treatment of HER-2-positive breast cancer brain metastases
Опухоли женской репродуктивной системы, 2016 Brain metastases are detectable in 25–35 % of patients with progressive HER-2-positve breast cancer. Even after spreading metastases into the brain, chemotherapy in combination with anti-HER- 2 therapy improves survival due to better control of the ...
G. A. Dashyan +11 more
doaj +1 more source
Norovirus infections and knowledge, attitudes and practices in food safety among food handlers in an informal urban settlement, Kenya 2017 [PDF]
, 2020 Eliud Wainaina +4 more
openalex +1 more source
Preferential trade agreements and the World Trade Organization: developments to the dispute settlement understanding [PDF]
, 2017 © 2017 Kluwer Law International BV, The Netherlands. On 21 March 2016, at the 9th Annual Update on World Trade Organization (WTO) Dispute Settlement, former Chairman of the Special Session of the Dispute Settlement Body (DSB), Ambassador Ronald Saborío ...
Hyams, Adam, Villalta Puig, Gonzalo
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
EFFICACY AND TOLERABILITY OF LACOSAMIDE (VIMPAT) FOR TREATMENT OF EPILEPSY IN ADULTS (A REVIEW)
Русский журнал детской неврологии, 2015 In spite of the significant progress achieved in epileptology, resistant forms of epilepsy comprise about 30 % of all cases of epilepsy. The articles reviews modern concepts and basic mechanisms of pharmacoresistance, as well as the ways to overcome them.
O. A. Pylaeva +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
BuildingsIn historic and cultural districts characterized by the coexistence of residential and commercial functions, street spaces play a pivotal role in shaping urban cultural continuity and local identity.
Lu Zhang +4 more
doaj +1 more source