Results 51 to 60 of about 1,973 (178)

Interdialytic blood pressure is independent of weight gain and correlated with serum angiotensin II levels in adults

Physiological Reports, Volume 14, Issue 9, May 2026.
Abstract Chronic volume overload is a major risk factor of hypertension and mortality in chronic dialysis patients. However, the mechanisms responsible for hypertension are unclear. We studied 32 patients (age 23–68 years, 19 females) in chronic hemodiafiltration classified by their interdialytic ambulatory blood pressure (idABP, mmHg) in three groups:
Adolfo Diaz, Brenda Delgado, Eduardo R. Argaiz, Olynka Vega, Ricardo Correa‐Rotter, Bernardo Rodriguez‐Iturbe   +5 more
wiley   +1 more source

Sevelamer hydrochloride and coronary artery calcification in chronic hemodialysis patients: a new mechanism of action

The Egyptian Journal of Internal Medicine, 2015
Background The non-calcium-based phosphate binder sevelamer hydrochloride was developed to provide chronic kidney disease patients with a polymer capable of managing hyperphosphatemia without an increase in the calcium load.
Bahaa Eldin Zayed, Hussein El-Fishawy, Amal R Al-Shihaby, Mohamed A Salem, Usama A.A. Sharaf El Din, Mona Mansour   +5 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis

, 2008
Background and objectives: Sevelamer carbonate is an improved, buffered form of sevelamer hydrochloride developed for the treatment of hyperphosphatemia in patients with chronic kidney disease.
Scott Chasan-taber, Oestergaard, Ove, Duggal, Ajay, Markus Ketteler, Stanley Fan, Chasan-Taber, Scott, Ketteler, Markus, Nicholas Pritchard, Heaton, Jeremy, Philip A. Kalra, Pritchard, N., Oestergaard, O., Marianne Rix, Heaton, J., Clin J Am Soc Nephrol, Rix, M., Duggal, A., Rix, Marianne, Jeremy Heaton, Ove Oestergaard, Ajay Duggal, Kalra, Philip A., Kalra, P.A., Ketteler, M., Chasan-Taber, S., Pritchard, Nicholas, Fan, S., Fan, Stanley   +27 more
core   +1 more source

A comparison between the combined effect of calcium carbonate with sucroferric oxyhydroxide and other phosphate binders: an in vitro and in vivo experimental study

BMC Nephrology, 2019
Background Approximately 30% of patients on dialysis received combination therapy for their phosphate binder prescription; however, few studies for combined effects of phosphate binders are reported.
Atsushi Yaguchi, Kenji Akahane, Kumi Tsuchioka, Saori Yonekubo, Shota Yamamoto, Yasuaki Tamai, Satoshi Tatemichi, Hiroo Takeda   +7 more
doaj   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

A Perfect Storm in Mineral Handling

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Introduction One of the commonest complications of end‐stage renal disease (ESRD) is the disruption of normal mineral trafficking, with a major perturbation in the handling of calcium and phosphate. Background Here, we report a patient who presented some time ago along with his imaging, with some of the worst sequelae of these issues.
Wael L. Jebur, Stephen G. Holt, Poorani Gurumallesh Prabu   +2 more
wiley   +1 more source

Single Center, Open‐Label, Randomized Crossover Trial on Drug–Drug Interactions of Levothyroxine/Magnesium‐Citrate and Levothyroxine/Magnesium‐Aspartate in Healthy Subjects—The ThyroMag Trial

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT Divalent cations such as calcium and ferrous sulfate interfere with the absorption of levothyroxine due to complexing. To our knowledge, the effects of magnesium on levothyroxine absorption have never been studied. The open‐label cross‐over pharmacokinetic study was conducted in 15 healthy, euthyroid adults.
Martin Christian Attinger, Stefanie von Felten, Claudia Lourenço Rodrigues, Jan Krützfeldt, Lorenz Risch, Jérôme Bonzon   +5 more
wiley   +1 more source

Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation

ChemistryOpen, Volume 14, Issue 10, October 2025.
The cyclodextrin polymer is conjugated with 35 deferoxamine units and can form iron(III) complexes. The polymer exhibits significantly lower antiproliferative activity than free deferoxamine. The cyclodextrin polymer with multiple deferoxamine units may present a promising strategy for improving the efficacy of iron chelation therapies.
Roberta Panebianco, Maurizio Viale, Graziella Vecchio   +2 more
wiley   +1 more source

Effect of bixalomer on coronary artery calcification in hemodialysis patients with hyperphosphatemia: a multi-center, randomized controlled trial

Renal Replacement Therapy, 2019
Background Calcium carbonate is a first-line therapy for hyperphosphatemia in hemodialysis patients but is associated with progressive coronary and aortic calcification. Sevelamer compounds are alternatives to calcium-containing phosphate binders as they
Takashi Akiba, Keitaro Yokoyama, Hiroki Hase, Masahide Mizobuchi, Ryoichi Ando, Shuji Sakai, Kenji Fukushima, Tadao Akizawa   +7 more
doaj   +1 more source