Results 101 to 110 of about 3,688,287 (401)
Targeting treatable traits in severe asthma: a randomised controlled trial
European Respiratory Journal, 2019 Rationale Treatable traits have been proposed as a new paradigm for airway disease management. Objectives To characterise treatable traits in a severe asthma population and to determine the efficacy of targeting treatments to these treatable traits in ...
V. McDonald +5 more
semanticscholar +1 more source
Biological Therapies of Severe Asthma and Their Possible Effects on Airway Remodeling
Frontiers in Immunology, 2020 Asthma is a chronic and heterogenic respiratory tract disorder with a high global prevalence. The underlying chronic inflammatory process and airway remodeling (AR) contribute to the symptomatology of the disease.
Grzegorz Kardas, P. Kuna, M. Panek
semanticscholar +1 more source
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
Advanced Science, EarlyView.During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source
Kocatepe Tıp Dergisi, 2018 Asthma is a common inflammatory disease that has wideclinical characteristics of the airway of the lungs. Asthmasymptoms can be prevented by avoiding triggers likeallergens and by the effective inhaled treatment. Themajority of asthma patients can be treated effectivelyby current medications.
SAĞMEN, Seda Beyhan, CEYHAN, Berrin
openaire +4 more sources
Outcomes over the first two years of treatment with mepolizumab in severe asthma [PDF]
, 2021 Lynn Elsey +4 more
openalex +1 more source
Journal of Asthma and Allergy, 2020 Rationale Results from clinical trials in patients with severe eosinophilic asthma have demonstrated that mepolizumab is well tolerated and is associated with improved asthma control as evidenced by reductions in both exacerbations and maintenance oral ...
J. Llanos +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang +15 more
wiley +1 more source
Preschool children with asthma: Do their GPs know? [PDF]
, 1999 Objective: To answer the following question: Are children with asthma known to their GP? Methods: Parents of all 464 children, 1-3 years of age and registered with five general practices, received a postal questionnaire asking about asthma symptoms of ...
Jongste, J.C. (Johan) de +5 more
core +1 more source
Advanced Science, EarlyView.This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi +8 more
wiley +1 more source
The paradigm shift in allergy consultations through a digital ecosystem
Frontiers in Digital HealthIn Spain, specialist outpatient care traditionally relied on in-person consultations at public hospitals, leading to long wait times and limited clinical analysis in appointment assignments.
Inmaculada Sánchez-Machín +5 more
doaj +1 more source