Results 101 to 110 of about 3,446,938 (405)

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

The Association of Nocturnal Asthma with Asthma Severity

Journal of Asthma, 1997
The objective of this study is to assess nocturnal asthma as a marker for poor control of asthma. Cross-sectional study of asthmatic patients was conducted in six general practices in East Anglia, England. Subjects were 240 asthma patients, between the ages of 20 and 54 years, from the above general practices.
Fix, A, Sexton, M, Langenberg, P, Santanello, N, Hyndman, S, Williams, R   +5 more
openaire   +4 more sources

Latino Asthma Epidemic [PDF]

, 2009
Chicago is known for many things, our great food and architecture. Unfortunately, we are also known for being an epi-center for asthma. We lead the Nation in asthma deaths, emergency room visits and hospitalizations.

core  

Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults

Allergy, Asthma & Clinical Immunology, 2021
Background Differences between adult patients with severe early-onset and late-onset asthma have not been well studied. Objectives To determine the phenotypic distinction regarding age at onset in patients with severe asthma.
Dandan Chen, Yu Zhang, Can Yao, Binbin Li, Sinian Li, Wenwen Liu, Rongchang Chen, Fei Shi   +7 more
doaj   +1 more source

Medical Costs and Productivity Loss Due to Mild, Moderate, and Severe Asthma in the United States

Journal of Asthma and Allergy, 2020
Background Little is known about economic and productivity loss by severity of asthma. We investigate health-care utilization, direct medical costs, and indirect costs due to productivity loss from asthma by severity.
H. Song, K. Blake, Debbie L. Wilson, A. Winterstein, Haesuk Park   +4 more
semanticscholar   +1 more source

A New EP300‐Related Syndrome With Prominent Developmental and Immune Phenotypes

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Rubinstein Taybi syndrome (RTS) is a disorder of chromatin remodeling and transcriptional regulation caused by heterozygous pathogenic variants in CREBBP and EP300. RTS is characterized by a distinct facial gestalt, intellectual disability, structural kidney and heart differences, feeding difficulties, and broad thumbs and great toes ...
Devi Priyanka Maripuri, Jessica Gold, Nina Gold, Alanna Strong   +3 more
wiley   +1 more source

Precision Medicine in Targeted Therapies for Severe Asthma:Is There Any Place for "omics" Technology? [PDF]

, 2018
According to the current guidelines, severe asthma still represents a controversial topic in terms of definition and management. The introduction of novel biological therapies as a treatment option for severe asthmatic patients paved the way to a ...
Bertolini, Francesca, Caminati, Marco, Facciolongo, Nicola, Galeone, Carla, Menzella, Francesco, Ruggiero, Patrizia, Scelfo, Chiara   +6 more
core   +2 more sources

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL‐1&bgr; secretion from monocytes and cause airway epithelial cell injury, but the ...
M. Lachowicz-Scroggins, E. Dunican, A. Charbit, W. Raymond, M. Looney, M. Peters, Erin D. Gordon, P. Woodruff, Emma Lefrançais, B. Phillips, D. Mauger, S. Comhair, S. Erzurum, M. Johansson, N. Jarjour, A. Coverstone, M. Castro, A. Hastie, E. Bleecker, M. Fajt, S. Wenzel, E. Israel, B. Levy, J. Fahy   +23 more
semanticscholar   +1 more source

Children With 22.Q.11.2 Deletion Syndrome: Sleep‐Disordered Breathing and Management

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Patients with 22q11.2 deletion syndrome (22q11DS) are predisposed to obstructive sleep apnea (OSA) due to an abnormal craniofacial anatomy with pharyngeal hypotonia, retrognathia, micrognathia, and glossoptosis. The aim of the study was to describe the prevalence and management of OSA in a cohort of children with 22q11DS.
Domenico Paolo La Regina, Sonia Khirani, Lucie Griffon, Clément Poirault, Raffaella Nenna, Fabio Midulla, Brigitte Fauroux   +6 more
wiley   +1 more source

Severe Asthma in Children [PDF]

The Journal of Allergy and Clinical Immunology: In Practice, 2014
Severe asthma in children is characterized by sustained symptoms despite treatment with high doses of inhaled corticosteroids or oral corticosteroids. Children with severe asthma may fall into 2 categories, difficult-to-treat asthma or severe therapy-resistant asthma. Difficult-to-treat asthma is defined as poor control due to an incorrect diagnosis or
Leonard B. Bacharier, Anne M. Fitzpatrick, Theresa W. Guilbert   +2 more
openaire   +3 more sources