Results 181 to 190 of about 3,446,938 (405)

Treatable traits can be identified in a severe asthma registry and predict future exacerbations

Respirology (Carlton South. Print), 2018
A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits ...
V. McDonald, S. Hiles, Krystelle Godbout, E. Harvey, G. Marks, M. Hew, M. Peters, P. Bardin, P. Reynolds, J. Upham, M. Baraket, Z. Bhikoo, J. Bowden, B. Brockway, L. Chung, B. Cochrane, Gloria J Foxley, J. Garrett, L. Jayaram, C. Jenkins, C. Katelaris, G. Katsoulotos, M. Koh, V. Kritikos, Marina Lambert, D. Langton, A. Lara Rivero, P. Middleton, A. Nanguzgambo, N. Radhakrishna, H. Reddel, J. Rimmer, A. Southcott, M. Sutherland, F. Thien, P. Wark, I. Yang, E. Yap, P. Gibson   +38 more
semanticscholar   +1 more source

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

Clinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek, Alexandra Cole, Viviana Bozón, Erika Manyak, Jonathan Novak, Barbara Yang, Briohny A. Johnston, Sudha Parasuraman, Kushal J. Paneliya, Virna Schuck   +9 more
wiley   +1 more source

Comparison of IV salbutamol with IV aminophylline in the treatment of severe, acute asthma in childhood. [PDF]

, 1979
G. Hambleton, MOSES J. STONE
openalex   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

Epidemiology of patients with severe asthma in Japan: a nationwide descriptive study

ERJ Open Research
Background The 2014 European Respiratory Society/American Thoracic Society guidelines defined severe asthma based on treatment intensity and estimated the proportion of severe asthma among all asthma cases to be 5–10%.
Yuya Kimura, Maho Suzukawa, Taisuke Jo, Yohei Hashimoto, Ryosuke Kumazawa, Miho Ishimaru, Hiroki Matsui, Akira Yokoyama, Goh Tanaka, Hideo Yasunaga   +9 more
doaj   +1 more source

Use of Real‐World Claims Data to Assess the Prevalence of Concomitant Medications to Inform Drug–Drug Interaction Risk in Target Patient Populations

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 146-155, July 2025.
A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang, Logan Brooks, Denise M. Boudreau, Pascal Chanu, Amita Joshi, Bianca Vora, Rui Zhu   +6 more
wiley   +1 more source

Severe Bronchial Asthma: Factors Influencing Intensive Care Management and Outcome [PDF]

, 1977
O.F.W. James, R. M. Mills, K. Murree Allen   +2 more
openalex   +1 more source

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation

Developmental Dynamics, EarlyView.
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel, Maya Silver, Aaron H. Wasserman, Samantha Rea, Charles C. Hong, Charles H. Williams   +5 more
wiley   +1 more source

The Evolution of Scientific Knowledge in Childhood Asthma over Time: A Surprising History

Children
Asthma is a disease that has been described since the times of Hammurabi. However, it is only since the 1960s that effective therapeutic strategies have been available.
Laura Venditto, Sonia Morano, Giuliana Ferrante, Michele Piazza, Laura Tenero, Giorgio Piacentini, Luca Pecoraro   +6 more
doaj   +1 more source

Management of severe acute asthma. [PDF]

, 1978

openalex   +1 more source