Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia [PDF]
Clinical ImmunologySevere combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow ...
Jasmeen Dara +2 more
exaly +7 more sources
The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions [PDF]
Journal of Allergy and Clinical Immunology, 2023 Severe combined immunodeficiency (SCID) results from defects in the differentiation of hematopoietic stem cells into mature T lymphocytes, with additional lymphoid lineages affected in particular genotypes.
Christopher C Dvorak +2 more
exaly +5 more sources
Introducing Newborn Screening for Severe Combined Immunodeficiency (SCID) in the Dutch Neonatal Screening Program [PDF]
International Journal of Neonatal Screening, 2018 The implementation of newborn screening for severe combined immunodeficiency (SCID) in the Netherlands is a multifaceted process in which several parties are involved. The Dutch Ministry of Health adopted the advice of the Dutch Health Council to include
Robbert Bredius, Mirjam Van Der Burg
exaly +7 more sources
Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment [PDF]
Microorganisms, 2023 Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal.
Angel A. Justiz-Vaillant +4 more
doaj +2 more sources
Generation and Characterization of Severe Combined Immunodeficiency Rats [PDF]
Cell Reports, 2012 Severe combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (Prkdc) deficiency, have contributed enormously to our understanding of immunodeficiency, lymphocyte development, and DNA-repair mechanisms, and they are ideal ...
Tomoji Mashimo +18 more
doaj +3 more sources
Screening for severe combined immunodeficiency in neonates [PDF]
Clinical Epidemiology, 2013 Brian T Kelly,1 Jonathan S Tam,1 James W Verbsky,1,2 John M Routes1,2 1Department of Pediatrics, 2Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA Abstract: Severe combined immunodeficiency (SCID) is a ...
Kelly BT, Tam JS, Verbsky JW, Routes JM
doaj +1 more source
Newborn Screening for Severe Combined Immunodeficiency in Israel [PDF]
International Journal of Neonatal Screening, 2017 Newborn screening (NBS) programs for severe combined immunodeficiency (SCID), the most severe type of primary immunodeficiency, are being implemented in more and more countries with every passing year.
Erez Rechavi +5 more
doaj +2 more sources
A Practical Guide to Implementing Population Newborn Screening (NBS) for Severe Combined Immunodeficiency (SCID) [PDF]
International Journal of Neonatal Screening, 2017 This review should be seen as a practical tool, one which we hope illustrates potential routes to follow when seeking to implement or lobby for severe combined immunodeficiency newborn screening (SCID NBS) at a national or regional level.
H. Bobby Gaspar
doaj +3 more sources
Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan [PDF]
Frontiers in Immunology, 2022 Severe combined immunodeficiency (SCID) is an inborn error of immunity that occurs in approximately 1 in 50,000 births, mainly due to impaired lymphocyte differentiation.
Kay Tanita +20 more
doaj +3 more sources
Development of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency [PDF]
Stem Cells and Cloning: Advances and Applications, 2009 Claudia A Montiel-Equihua, Adrian J Thrasher, H Bobby GasparCentre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, UKAbstract: The history of stem cell gene therapy is strongly linked to the development of gene ...
Claudia A Montiel-Equihua +2 more
doaj +1 more source