Results 31 to 40 of about 19,116 (219)
Bilateral extensive CMV retinitis in a sick child – Harbinger of severe combined immunodeficiency
Journal of Pediatric Critical Care, 2017 Cytomegalovirus (CMV) retinitis is a marker of severe cellular immunodeficiency. Severe combined immunodeficiency (SCID) must be considered in infants presenting with CMV retinitis in a non-HIV setting.
H S Vinayaka +3 more
doaj +1 more source
Severe combined immunodeficiencies (SCID) [PDF]
Clinical and Experimental Immunology, 2000 SCID consists of a group of genetic disorders characterized by a block in T lymphocyte differentiation that is variably associated with abnormal development of other lymphocyte lineages, i.e. B or NK lymphocytes or more rarely of the myeloid lineage [1,2].
openaire +2 more sources
Adriamycin nephropathy in severe combined immunodeficient (SCID) mice [PDF]
Nephrology Dialysis Transplantation, 2006 Experimental focal glomerulosclerosis is a model of chronic proteinuric renal disease that has been induced in both rats and mice. In mice, the adriamycin (ADR)induced nephropathy model is a robust experimental analogue of human focal glomerulosclerosis [1].
Vincent W S, Lee +9 more
openaire +2 more sources
Frontiers in Immunology, 2020 Pigs with severe combined immunodeficiency (SCID) are an emerging biomedical animal model. Swine are anatomically and physiologically more similar to humans than mice, making them an invaluable tool for preclinical regenerative medicine and cancer ...
Adeline N. Boettcher +26 more
doaj +1 more source
Frontiers in Genetics, 2023 Here, we report a case of rubella virus-induced granulomatous dermatitis in a young girl with immunodeficiency caused by DCLRE1C gene mutations. The patient was a 6-year-old girl who presented with multiple erythematous plaques on the face and limbs ...
Sihan Deng +4 more
doaj +1 more source
CD3ε+ Cells in Pigs With Severe Combined Immunodeficiency Due to Defects in ARTEMIS
Frontiers in Immunology, 2020 Severe combined immunodeficiency (SCID) is described as the lack of functional T and B cells. In some cases, mutant genes encoding proteins involved in the process of VDJ recombination retain partial activity and are classified as hypomorphs. Hypomorphic
Adeline N. Boettcher +15 more
doaj +1 more source
Gene therapy in PIDs, hemoglobin, ocular, neurodegenerative, and hemophilia B disorders
Open Life Sciences, 2021 A new approach is adopted to treat primary immunodeficiency disorders, such as the severe combined immunodeficiency (SCID; e.g., adenosine deaminase SCID [ADA-SCID] and IL-2 receptor X-linked severe combined immunodeficiency [SCID-X1]).
Odiba Arome Solomon +3 more
doaj +1 more source
A Novel Homozygous JAK3 Mutation Leading to T-B+NK– SCID in Two Brazilian Patients
Frontiers in Pediatrics, 2018 We report a novel homozygous JAK3 mutation in two female Brazilian SCID infants from two unrelated kindreds. Patient 1 was referred at 2 months of age due to a family history of immunodeficiency and the appearance of a facial rash.
Lucila A. Barreiros +6 more
doaj +1 more source
Establishing Newborn Screening for SCID in the USA: Experience in California
International Journal of Neonatal Screening, 2021 Newborn screening for severe combined immunodeficiency (SCID) has developed from the realization that infants affected with SCID require prompt diagnosis and treatment to avoid fatal infectious complications.
Jennifer M. Puck, Andrew R. Gennery
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In vitro T cell depletion using Campath 1M for mismatched BMT for severe combined immunodeficiency (SCID) [PDF]
, 1997 Bone marrow transplantation is the only curative treatment for children with severe combined immunodeficiency (SCID), In the absence of an HLA-identical sibling, haploidentical parental donor marrow can be used provided it is depleted of T cells to ...
Peak, J. +6 more
core +1 more source