Results 61 to 70 of about 19,116 (219)

Newborn Screening for SCID and Other Severe Primary Immunodeficiency in the Polish-German Transborder Area: Experience From the First 14 Months of Collaboration

Frontiers in Immunology, 2020
In 2017, in the Polish-German transborder area of West Pomerania, Mecklenburg-Western Pomerania, and Brandenburg, in collaboration with two centers in Warsaw, a partnership in the field of newborn screening (NBS) for severe primary immunodeficiency ...
Maria Giżewska, Maria Giżewska, Katarzyna Durda, Theresa Winter, Theresa Winter, Iwona Ostrowska, Mariusz Ołtarzewski, Jeannette Klein, Oliver Blankenstein, Hanna Romanowska, Hanna Romanowska, Elżbieta Krzywińska-Zdeb, Elżbieta Krzywińska-Zdeb, Michał Filip Patalan, Michał Filip Patalan, Elżbieta Bartkowiak, Natalia Szczerba, Stefan Seiberling, Bożena Birkenfeld, Bożena Birkenfeld, Matthias Nauck, Matthias Nauck, Horst von Bernuth, Horst von Bernuth, Horst von Bernuth, Christian Meisel, Christian Meisel, Ewa Anna Bernatowska, Mieczysław Walczak, Mieczysław Walczak, Małgorzata Pac   +30 more
doaj   +1 more source

Severe Combined Immunodeficiency Disorder due to a Novel Mutation in Recombination Activation Gene 2: About 2 Cases

Case Reports in Immunology, 2021
Severe combined immunodeficiency (SCID) comprises a heterogeneous group of inherited immunologic disorders with profound defects in cellular and humoral immunity. SCID is the most severe PID and constitutes a pediatric emergency.
Ibtihal Benhsaien, Fatima Ailal, Khadija Elazhary, Jalila El bakkouri, Abdallah Badou, Ahmed Aziz Bousfiha   +5 more
doaj   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Il2rg Gene-Targeted Severe Combined Immunodeficiency Pigs [PDF]

, 2012
SummaryA porcine model of severe combined immunodeficiency (SCID) promises to facilitate human cancer studies, the humanization of tissue for xenotransplantation, and the evaluation of stem cells for clinical therapy, but SCID pigs have not been ...
Ishikawa, Fumihiko, Sakata, Yoichi, Suzuki, Misae, Takagi, Shinsuke, Suzuki, Shunichi, Fuchimoto, Daiichiro, Hashimoto, Michiko, Saito, Yoriko, Mikawa, Satoshi, Mimuro, Jun, Suzuki, Emi, Suzuki, Nahoko, Perry, Anthony C.F., Kubo, Masanori, Madoiwa, Seiji, Iwamoto, Masaki, Aoki, Yuki, Kashiwakura, Yuji, Sembon, Shoichiro, Onishi, Akira, Najima, Yuho   +20 more
core   +1 more source

Long Term Follow-Up of the Patients with Severe Combined Immunodeficiency After Hematopoietic Stem Cell Transplantation: A Single-Center Study. [PDF]

, 2022
Background: We aimed to evaluate hematopoietic stem cell transplantation (HSCT) related outcomes of patients with severe combined immunodeficiency (SCID)
Demirtas, Duygu, Turul Ozgur, Tuba, Uckan Cetinkaya, Duygu, Cagdas, DENİZ NAZİRE, Kuskonmaz, BÜLENT BARIŞ, Sanal, Ozden, Tezcan, Ilhan   +6 more
core   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Gene Therapy As A Treatment Modality For Severe Combined Immunodeficiency : A Narrative Review

High Yield Medical Reviews
Introduction: Severe combined immunodeficiency (SCID) is a life-threatening genetic disorder marked by severe T-cell defects and often B-cell and NK-cell dysfunction, leading to an increased risk of infections.
Namareq Al-Mse'adeen, Ayham Al Mse'adeen
doaj   +1 more source

Clinical progress note: Rotavirus

Journal of Hospital Medicine, EarlyView.
Abstract Rotavirus is a vaccine‐preventable cause of acute, viral gastroenteritis typically characterized by diarrhea, vomiting, and fever. Prior to rotavirus vaccine introduction, nearly all children worldwide had been infected by 5 years of age. Severe rotavirus gastroenteritis causes dehydration and electrolyte derangements, and infants and young ...
Kelsey Thetford, Meghan Hofto
wiley   +1 more source

Cost-effectiveness of newborn screening for severe combined immunodeficiency. [PDF]

, 2019
Severe combined immunodeficiency (SCID) is a condition that often results in severe infections and death at young age. Early detection shortly after birth, followed by treatment before infections occur, largely increases the chances of survival.
van den Akker-van Marle, M Elske, Schielen, Peter C J I, Van der Ploeg, Catharina P B, Bredius, Robbert G M, van der Burg, Mirjam, Blom, Maartje, Verkerk, Paul H   +6 more
core   +1 more source