Results 91 to 100 of about 327,068 (394)

Rapid effect of benralizumab in exacerbation of severe eosinophilic asthma associated with eosinophilic granulomatosis with polyangiitis

BMC Pulmonary Medicine, 2021
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease that is associated with severe uncontrolled eosinophilic asthma. Eosinophils play an important pathogenic role in the development of both diseases.
Carlos Martínez-Rivera, Ignasi Garcia-Olivé, Blanca Urrutia-Royo, Maria Basagaña-Torrento, Antoni Rosell, Jorge Abad   +5 more
doaj   +1 more source

Interpretable Machine Learning for COVID-19: An Empirical Study on Severity Prediction Task [PDF]

IEEE Transactions on Artificial Intelligence, 2021, 2020
The black-box nature of machine learning models hinders the deployment of some high-accuracy models in medical diagnosis. It is risky to put one's life in the hands of models that medical researchers do not fully understand. However, through model interpretation, black-box models can promptly reveal significant biomarkers that medical practitioners may
arxiv   +1 more source

TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis. [PDF]

, 2020
Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier
Aceves, SS, Barrett, K, Bezryadina, A, Dohil, R, Duong, LD, Kurten, R, Liu, Z, Manresa, MC, Newbury, RO, Rawson, R   +9 more
core  

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]

, 2015
Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds
AT Nathan, B Schaub, BA Fallert, Bart N. Lambrecht, Bernhard Ryffel, Beth A. Fallert Junecko, BN Lambrecht, BN Lambrecht, BN Lambrecht, BR O'Driscoll, C Braun-Fahrlander, CE Reed, David L. Williams, DC Newcomb, EC Cates, F Gerosa, F Kirstein, Frank Brombacher, Frank Kirstein, G Trinchieri, GD Brown, Gordon D. Brown, GP Anderson, Graeme Murray, H Hammad, HE Ensley, HS Goodridge, I Agache, J Chakir, J Douwes, J Thorn, J Zhao, Jay K. Kolls, JB Allard, JH Bonlokke, JL Simpson, Kaat Fierens, KM Dennehy, KM Dennehy, Kong Chen, L Dong, L McKinley, LG Gregory, LK Fogli, LM Lilly, M Kudo, M Laan, M Plantinga, M Rosas, N Pearce, NN Jarjour, PC Porter, Pierre Redelinghuys, PJ Barnes, R Rylander, RA Drummond, RA Martin, RA Mintz-Cole, RA Mintz-Cole, Rebecca A. Drummond, RH Wilson, S Ano, S Saad-El-Din Bessa, Sabelo Hadebe, Sara Sajaniemi, SC Cheng, SC Eisenbarth, Simon Vautier, Todd A. Reinhart, W Eder, WC Moore, ZZ Pan   +71 more
core   +8 more sources

Biological function of eosinophil extracellular traps in patients with severe eosinophilic asthma [PDF]

Experimental & Molecular Medicine, 2018
AbstractEosinophil extracellular traps (EETs), a complex of DNA fibers and cytotoxic granule proteins, are implicated in the development of asthma; however, the pathophysiological function of EETs in immune responses has not been fully determined. The present study investigated the characteristics of EETs from patients with non-severe asthma (NSA,n ...
Youngwoo Choi, Duy Le Pham, Dong-Hyun Lee, So-Hee Lee, Seung-Hyun Kim, Hae-Sim Park   +5 more
openaire   +3 more sources

Artificial Intelligence-based Eosinophil Counting in Gastrointestinal Biopsies [PDF]

arXiv, 2022
Normally eosinophils are present in the gastrointestinal (GI) tract of healthy individuals. When the eosinophils increase beyond their usual amount in the GI tract, a patient gets varied symptoms. Clinicians find it difficult to diagnose this condition called eosinophilia. Early diagnosis can help in treating patients.
arxiv  

Eosinophil Apoptosis and Clearance in Asthma [PDF]

, 2013
Peer reviewedPublisher ...
Bickham U.R., Duval E., Fadok V.A., Fadok V.A., Gaipl U.S., Hart S.P., Luttmann W., Meagher L.C., Schwartz B.R., Walsh G.M.   +9 more
core   +3 more sources

Benralizumab in children with severe eosinophilic asthma: Pharmacokinetics and long‐term safety (TATE study)

Pediatric Allergy and Immunology
Benralizumab is an anti‐interleukin‐5 receptor α monoclonal antibody approved as an add‐on maintenance treatment for patients with uncontrolled severe asthma.
H. Wedner, Takao Fujisawa, T. Guilbert, Masanori Ikeda, Vinay Mehta, Jonathan S. Tam, Pradeep B. Lukka, S. Asimus, T. Durżyński, J. Johnston, Wendy I. White, Mihir Shah, V. Werkström, M. Jison   +13 more
semanticscholar   +1 more source

MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of miR‐221‐3p in CRSwNP is unclear. Methods Ethmoid tissues
Ruowu Liu, Jiao Zhou, Jing Zhou, Feng Liu, Yafeng Liu, Juan Meng, Luo Ba, Hengyi Xiao, Shixi Liu, Nan Zhang, Claus Bachert, Jintao Du   +11 more
wiley   +1 more source

Mepolizumab, quality of life, and severe eosinophilic asthma [PDF]

The Lancet Respiratory Medicine, 2017
It is now ten years since the publication of the first clinical trial, eight years since the first key proof of concept studies in a population selected on the basis of inflammatory pattern and two years since approval of Mepolizumab as a treatment for severe eosinophilic asthma.
openaire   +4 more sources